Monophosphoryl lipid A analogues with varying 3-O-substitution: synthesis and potent adjuvant activity

Carbohydrate Research

Volumn 342, Issue 6, 2007, Pages 784-796

  Jiang, Zi Hua ^a   Budzynski, Wladyslaw A ^a   Qiu, Dongxu ^a   Yalamati, Damayanthi ^a   Koganty, R Rao ^a  

^a Biomira Inc   (Canada)

Author keywords

Cytokine; Glycolipid; Immunostimulant; Monophosphoryl lipid A; Vaccine adjuvant

Indexed keywords

CYTOKINE; GLYCOLIPIDS; IMMUNOSTIMULANTS; MONOPHOSPHORYL LIPID A; VACCINE ADJUVANT;

IMMUNOLOGY; POLYSACCHARIDES; SUBSTITUTION REACTIONS; SUGARS; SYNTHESIS (CHEMICAL); VACCINES;

LIPIDS;

3 O ALLYL 4 O BENZYL 2 DEOXY 2 (3 TETRADECANOYLOXYTETRADECANAMIDO) BETA DEXTRO GLUCOPYRANOSIDE; 3,4 DI O BENZYL 2 DEOXY 2 (3 TETRADECANOYLOXYTETRADECANAMIDO) BETA DEXTRO GLUCOPYRANOSIDE; 4,6 DI O BENZYLIDENE 2 DEOXY 2 (2',2',2' TRICHLOROETHOXYCARBONYLAMINO) ALPHA DEXTRO GLUCOPYRANOSYL TRICHLOROACETIMIDATE; GAMMA INTERFERON; GLUCOPYRANOSIDE; LIPOSOME; PHOSPHORYL LIPID A; SUGAR; TRICHLOROACETIMIDIC ACID; UNCLASSIFIED DRUG; VACCINE;

ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; BACTERIUM ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; DEBENZYLATION; DETOXIFICATION; DRUG ACTIVITY; DRUG SYNTHESIS; EX VIVO STUDY; GLYCOSYLATION; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA MINNESOTA; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CARBOHYDRATE CONFORMATION; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERFERON TYPE II; LIPID A; MICE; MOLECULAR STRUCTURE; T-LYMPHOCYTES; TOXICITY TESTS;

SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR MINNESOTA;

EID: 33847204580     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2007.01.012     Document Type: Article

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