Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 8, 2013, Pages 2370-2378

  Sánchez, Ana I ^a   Martínez Barrasa, Valentín ^a,c   Burgos, Carolina ^a   Vaquero, Juan J ^a   Alvarez Builla, Julio ^a   Terricabras, Emma ^b   Segarra, Víctor ^b  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b Almirall Prodesfarma ^*  (Spain)

^c PHARMAMAR S A   (Spain)

Author keywords

Biphenyls; Phosphodiesterase 7; Quinazoline

Indexed keywords

1H QUINAZOLINE 2,4 DITHIONE DERIVATIVE; 2 (4 CHLOROPHENYL) 3H QUINAZOLIN 4 THIONE; 2 (4 CHLOROPHENYL) 4 [2' (1H TETRAZOL 5 YL)BIPHENYL 4 YLMETHYLSULFANYL]QUINAZOLINE; 2 BENZYLSULFANYL 3H QUINAZOLIN 4 ONE DERIVATIVE; 2 BENZYLSULFANYL 3H QUINAZOLIN 4 THIONE DERIVATIVE; 2 METHYL 4 [4' (1 H TETRAZOL 5 YL)BIPHENYL 4 YL METHYLSULFANYL]QUINAZOLINE; 3H QUINAZOLIN 4 ONE DERIVATIVE; 3H QUINAZOLIN 4 THIONE DERIVATIVE; 4 (2 ISOPROPYLQUINAZOLIN 4 YLSULFANYLMETHYL)BIPHENYL 2 CARBONITRILE; 4 (2 ISOPROPYLQUINAZOLIN 4 YLSULFANYLMETHYL)BIPHENYL 2 CARBOXYLIC ACID; 4 (2 ISOPROPYLQUINAZOLIN 4 YLSULFANYLMETHYL)BIPHENYL 3 CARBOXYLIC ACID; 4 (2 ISOPROPYLQUINAZOLIN 4 YLSULFANYLMETHYL)BIPHENYL 4 CARBOXYLIC ACID; 4 (2 METHYLQUINAZOLIN 4 YLSULFANYLMETHYL)BIPHENYL 2 CARBONITRILE; 4 (2 TRICHLOROMETHYLQUINAZOLIN 4 YLSULFANYLMETHYL)BIPHENYL 2 CARBONITRILE; 4 (QUINAZOLIN 4 YLSULFANYLMETHYL)BIPHENYL 2 CARBONITRILE; 4 [2 (4 NITROBENZYLSULFANYL)QUINAZOLIN 4 YLSULFANYLMETHYL] 1,1' BIPHENYL 2 CARBONITRILE; 4 [2' (1H TETRAZOL 5 YL)BIPHENYL 4YLMETHYLSULFANYL] 2 TRICHLOROMETHYLQUINAZOLINE; 4 [2' (1H TETRAZOL 5 YL)BIPHENYL]QUINAZOLINE DERIVATIVE; 4 [2' (1H TETRAZOLE 5 YL)BIPHENYL 4 YLMETHYLSULFANYL] 2 [3' (1H TETRAZOLE 5 YL)BIPHENYL 4 YLMETHYLSULFANYL]QUINAZOLINE; 5,7 DIBROMO 2 PHENETHYL 3H QUINAZOLIN 4 ONE; 5,7 DIBROMO 2 PHENETHYL 4 [3' (1H TETRAZOL 5 YL)BIPHENYL 4 YLMETHYLSULFANYL]QUINAZOLINE; 5,7 DIBROMO 2 PHENETHYL 4 [3' (1H TETRAZOL 5 YL)BIPHENYL 4YLMETHYLSULFANYL]QUINAZOLINE; 6,7,8 TRIMETHOXY 2 PHENETHYL 3H QUINAZOLIN 4 THIONE; 6,7,8 TRIMETHOXY 2 PHENETHYL 4 [2' (1H TETRAZOL 5 YL)BIPHENYL 4 YLMETHYLSULFANYL]QUINAZOLINE; BIPHENYL DERIVATIVE; BIPHENYLCARBOXYLIC ACID METHYLSULFANY 2 ISOPROPYLQUINAZOLINE DERIVATIVE; PHOSPHODIESTERASE VII INHIBITOR; QUINAZOLIN 4 THIONE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 7; PHOSPHODIESTERASE INHIBITORS; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875739596     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.067     Document Type: Article

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