Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 5, 1998, Pages 505-510

  Segarra, Victor ^a   Crespo, M Isabel ^a   Pujol, Ferran ^a   Beleta, Jorge ^a   Doménech, Teresa ^a   Miralpeix, Montserrat ^a   Palacios, Jose M ^a   Castro, Ana ^b   Martinez, Ana ^b  

^a Almirall Prodesfarma Research Center ^*  (Spain)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; LOSARTAN; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV;

ARTICLE; CONTROLLED STUDY; DATA BASE; DRUG DESIGN; DRUG DEVELOPMENT; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

ANIMALS; DRUG DESIGN; GUINEA PIGS; HEART VENTRICLES; LOSARTAN; PHOSPHODIESTERASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032478052     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00058-4     Document Type: Article

References (25)

1. 1. Palfreyman, M.N. Drugs of the Future, 1995, 20, 793.
2. 2. Christensen, S.B.; Torphy, T.J. Ann. Rep. Med. Chem., 1994, 29, 185.
3. 3. Sofia, M.J.; Steven, A.S. Ann. Rep. Med. Chem., 1993, 28, 109.
4. 4. Stafford, J.A.; Feldman, P.L. Ann. Rep. Med. Chem., 1996, 31, 71.
5. 5. Palacios, J.M.; Beleta, J.; Segarra, V. Il Farmaco, 1995, 50, 819.
6. 6. Crespo, M.I.; Prieto, J.M.; Vega, A.; Segarra, V.; Domenech, T.; Miralpeix, M.; Beleta, J.; Palacios, J.M. 14th International Symposium on Medicinal Chemistry, Maastricht, The Nederlands, P-5.14. September, 1996
7. 7. López, M.; Segarra, V.; Crespo, M.I.; Beleta, J.; Palacios, J.M. 14th International Symposium on Medicinal Chemistry, Maastricht, The Nederlands, P-5.36, September, 1996
8. 8. Lowe, J.A.; Archer, R.L.; Chapin, D.S.; Cheng, J.B.; Heiweg, D.; Johnson, J.L.; Koe, B.K.; Lebel, L.A.; Moore, P.F.; Nielsen, J.A.; Russo, L.L.; Shirley, J.T. J. Med. Chem. 1991, 34, 341.
9. 9. Lowe, J.A.; Cheng, J.B. Drugs of the Future 1992, 17, 799.
10. 10. Finn, P.W. Drug Discovery Today 1996, 1, 363.
11. 11. Wang, S.; Zaharevitz, D.W.; Sharma, R.; Marquez, V.E.; Lewin, N.E:; Du, L.; Blumberg, P.M.; Milne, G.W.A. J. Med. Chem. 1994, 37, 4479.
12. 12. Martin, Y.C. J. Med. Chem. 1992, 35, 2145.
13. 13. Chem-X, Oct96 version, Chemical Design limited, Oxfordshire OX7 5SR, England.
14. 14. Murrall, N.W.; Davies, E.K. J. Chem. Inf. Comput. Sci. 1990, 30, 312.
15. 15. Ishizaki, H.; Ohtawa, M. Biochem. Pharmacol. 1994, 48, 201.
16. 16. Sharma, R.K.; Smith, J.R.; Moore, G.J. Biochem. Biophys. Res. Commun. 1991, 179, 85.
17. 17. Dal Piaz, V.; Giovannoni, M.P.; Castellana, C.; Palacios, J.M.; Beleta, J.; Domenech, T.; Segarra, V. J. Med. Chem. 1997, 40, 1417.
18. 18. Elderfield, R.C. In Heterocyclic Compounds, J. Wiley and Sons: New York, 1957; Vol. 6, pp. 324-376.
19. 19. Irwin, W.J.; Wibberley, D.G. J. Chem. Soc., 1965, 4240.
20. 20. Bowie, R.A.; Thomason, D.A. J. Chem. Soc. Perkin Trans. I, 1972, 1842.
21. 21. Bradburry, R.H.; Allott, C.P.; Dennis, M.; Fisher, E.; Major, J.S.; Masek, B.B.; Oldham, A.A.; Pearce, R.J.; Rankine, N.; Revill, J.M.; Roberts, D.A.; Russell, S.T. J. Med. Chem. 1992, 35, 4027.
22. 22. Winn, M.; De, B.; Zydowsky, T.M.; Altenbach, R.L.; Basha, F.Z.; Boyd, S.A.; Brune, M.E.; Buckner, S.A.; Crowell, D.A.; Drizin, I.; Hancock, A.A.; Jae, H.S.; Kester, J.A.; Lee, J.Y.; Mantei, R.A.; Marsh, K.C.; Novosad, E.I.; Oheim, K.W.; Rosenberg, S.H.; Shiosaki, K.; Sorensen, B.K.; Spina, K.; Sullivan, G.M.; Tasker, A.S.; von Geldern, T.W.; Warner, R.B.; Opgenorth, T.J.; Kerkman, D.J.; DeBernardis, J.F. J. Med. Chem. 1993, 36, 2676.
23. 23. Carini, D.J.; Duncia, J.V.; Aldrich, P.E.; Chui, A.T.; Johnson, A.L.; Pierce, W.A.; Santella, J.B.; Wells, G.J.; Wexler, R.R.; Wong, P.C.; Yoo, S.E.; Timmermans, P.B. J. Med. Chem. 1991, 34, 2525.
24. 24. Castro, A.; Martinez, A. Heterocycles, 1994, 38, 1737.
25. 25. Martinez, A.; Castro, A.; Fonseca, I.; Martinez-Ripoll, M.; Cano, F.H.; Albert, A. Heterocycles, 1996, 43, 2657.