ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-α level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice

European Journal of Pharmacology

Volumn 613, Issue 1-3, 2009, Pages 163-166

  Kadoshima Yamaoka, Kumiko ^a   Goto, Megumi ^a   Murakawa, Masao ^a   Yoshioka, Ryosuke ^a   Tanaka, Yoshitaka ^a   Inoue, Hidekazu ^a   Murafuji, Hidenobu ^a   Kanki, Satomi ^a   Hayashi, Yasuhiro ^a   Nagahira, Kazuhiro ^a   Ogata, Atsuto ^a   Nakatsuka, Takashi ^a   Fukuda, Yoshiaki ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Keratinocyte; Phosphodiesterase 7 (PDE7); Psoriasis; Skin inflammation; TNF

Indexed keywords

1 CYCLOHEXYL N [6 (4 HYDROXY 1 PIPERIDINYL) 3 PYRIDINYL] 3 METHYL 1H THIENO[2,3 C]PYRAZOLE 5 CARBOXAMIDE; ADENYLATE CYCLASE; ASB 16165; BUCLADESINE; CALCIUM IONOPHORE; CYTOKINE; FORSKOLIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHODIESTERASE VII; PHOSPHODIESTERASE VII INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATITIS; ENZYME INHIBITION; EPIDERMIS; FEMALE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KERATINOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SKIN EDEMA; SKIN INFLAMMATION;

ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 7; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; ENZYME INHIBITORS; EPIDERMIS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; KERATINOCYTES; MICE; MICE, INBRED BALB C; PYRAZOLES; SKIN; TETRADECANOYLPHORBOL ACETATE; THIOPHENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 65749095003     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.04.014     Document Type: Article

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