Synthesis and in vitro antitumor activities of xanthone derivatives containing 1,4-disubstituted-1,2,3-triazole moiety

Archives of Pharmacal Research

Volumn 35, Issue 12, 2012, Pages 2093-2104

  Zou, Yan ^a   Zhao, Qingjie ^a   Hu, Honggang ^a   Hu, Lina ^a   Yu, Shichong ^a   Xu, Mingjuan ^b   Wu, Qiuye ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

1,2,3 Triazoles; Antitumor activity; Click chemistry; Xanthone

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 1,3 DIMETHOXY 7 [[1 (2 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2 CYANOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2,4 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (2,6 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (3 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (3 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (3 CYANOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (3 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (3 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (3 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (3 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (4 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (4 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (4 CYANOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (4 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (4 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; 1,3 DIMETHOXY 7 [[1 (4 TERT BUTYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINO] 9H XANTHEN 9 ONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CLICK CHEMISTRY; CONCENTRATION RESPONSE; DRUG SYNTHESIS; HELA CELL; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; TRIAZOLES; XANTHONES;

EID: 84875738256     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-1206-4     Document Type: Article

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