Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 3445-3455

  Kostakis, Ioannis K ^a   Pouli, Nicole ^a   Marakos, Panagiotis ^a   Kousidou, Olga Ch ^b   Roussidis, Andreas ^b   Tzanakakis, George N ^c   Karamanos, Nikos K ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c UNIVERSITY OF CRETE   (Greece)

Author keywords

Aminosubstituted xantheno 1,2 d imidazoles; Antiproliferative activity; Breast cancer cells

Indexed keywords

2 (PIPERIDIN 1 YL METHYL) 1H,11H XANTHENO[1,2 D]IMIDAZOL 11 ONE; 2 (PIPERIDIN 1 YL) N [2 (PIPERIDIN 1 YL METHYL) 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 5 YL]ACETAMIDE; 2 (PYRROLIDIN 1 YL METHYL) 1H,11H XANTHENO[1,2 D]IMIDAZOL 11 ONE; 2 (PYRROLIDIN 1 YL) N [2 (PYRROLIDIN 1 YL METHYL) 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 5 YL]ACETAMIDE; 2 CHLORO N [2 (DIETHYLAMINOMETHYL) 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 5 YL]ACETAMIDE; 2 CHLORO N [2 (DIMETHYLAMINOMETHYL) 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 5 YL]ACETAMIDE; 2 CHLORO N [2 (PIPERIDIN 1 YL METHYL) 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 5 YL]ACETAMIDE; 2 CHLORO N [2 (PYRROLIDIN 1 YL METHYL) 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 5 YL]ACETAMIDE; 2 DIETHYLAMINO N [2 (DIETHYLAMINOMETHYL) 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 5 YL]ACETAMIDE; 2 DIMETHYLAMINO N [2 (DIMETHYLAMINOMETHYL) 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 5 YL]ACETAMIDE; 5 NITRO 2 (PIPERIDIN 1 YL METHYL) 1H,11H XANTHENO[1,2 D]IMIDAZOL 11 ONE; 5 NITRO 2 (PYRROLIDIN 1 YL METHYL) 1H,11H XANTHENO[1,2 D]IMIDAZOL 11 ONE; IMIDAZOLE DERIVATIVE; MITOXANTRONE; N,N DIETHYL [(11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 2 YL)METHAN]AMINE; N,N DIETHYL [[5 NITRO 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 2 YL]METHAN]AMINE; N,N DIMETHYL [(11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 2 YL)METHAN]AMINE; N,N DIMETHYL [[5 NITRO 11 OXO 1H,11H XANTHENO[1,2 D]IMIDAZOL 2 YL]METHAN]AMINE; UNCLASSIFIED DRUG; XANTHENE DERIVATIVE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CELL SIZE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; GENE AMPLIFICATION; HUMAN; HUMAN CELL;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FEMALE; HUMANS; IMIDAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41249103475     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.003     Document Type: Article

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