First identification of xanthone sulfonamides as potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 10, 2010, Pages 3094-3097

  Hu, Honggang ^a   Liao, Hongli ^c   Zhang, Jun ^a   Wu, Weifeng ^a   Yan, Jufang ^b   Yan, Yonghong ^b   Zhao, Qingjie ^a   Zou, Yan ^a   Chai, Xiaoyun ^a   Yu, Shichong ^a   Wu, Qiuye ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Pharmaceutical Institute   (China)

^c CHENGDU MEDICAL COLLEGE   (China)

Author keywords

Acyl CoA:cholesterol acyltransferase (ACAT); Inhibitor; Sulfonamide; Xanthone

Indexed keywords

1,3,6,7 TETRAMETHOXYXANTHONE 4 SULFONAMIDE DERIVATIVE; 3 DECYLDIMETHYLSILYL N [2 (4 METHYLPHENYL) 1 PHENYLETHYL]PROPIONAMIDE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG; XANTHONE SULFONAMIDE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DEMETHYLATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACETYL-COA C-ACETYLTRANSFERASE; CATALYTIC DOMAIN; COMPUTER SIMULATION; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; XANTHONES;

EID: 77952101896     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.101     Document Type: Article

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