Synthesis, modelling, and antimitotic properties of tricyclic systems characterised by a 2-(5-phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole moiety

ChemMedChem

Volumn 4, Issue 6, 2009, Pages 998-1009

  Pinna, Gérard A ^b   Murineddu, Gabriele ^b   Murruzzu, Caterina ^b   Zuco, Valentina ^c   Zunino, Franco ^c   Cappelletti, Graziella ^a   Artali, Roberto ^a   Cignarella, Giorgio ^a   Solano, Lucrezia ^a   Villa, Stefania ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Antitumor agents; Cytotoxicity; Molecular modeling; Oxadiazoles; Tubulin polymerisation

Indexed keywords

2 (5 PHENYL 1H PYRROL 3 YL) 1,3,4 OXADIAZOLE DERIVATIVE; 3 (1,3,4 OXADIAZOL 5 PHENYL 2 YL) 1,4 DIHYDROINDENO[1,2 B]PYRROLE; 3 (1,3,4 OXADIAZOL 5 PHENYL 2 YL) 1H BENZO[G]INDOLE; OXADIAZOLE DERIVATIVE; PACLITAXEL; PROTEIN P53; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE M PHASE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTIMITOTIC AGENTS; APOPTOSIS; BINDING SITES; BIOLOGICAL MARKERS; CELL CYCLE; CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDENES; INDOLES; MODELS, CHEMICAL; OXADIAZOLES; PYRROLES; TUBULIN;

EID: 67049116263     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800428     Document Type: Article

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