Synthesis, cyclooxygenase inhibitory effects, and molecular modeling study of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and -2-alkylsulfonyl-1H- imidazole derivatives

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 8, 2013, Pages 2355-2362

  Assadieskandar, Amir ^a   Amirhamzeh, Amirali ^a   Salehi, Marjan ^a   Ozadali, Keriman ^b,c   Ostad, Seyed Nasser ^a   Shafiee, Abbas ^d   Amini, Mohsen ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF ALBERTA   (Canada)

^c HACETTEPE UNIVERSITY   (Turkey)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

2 Alkylsulfonyl 1H imidazole; 2 Alkylthio 1H imidazole; Cyclooxygenase; Docking; Human whole blood assay; Tautomerization

Indexed keywords

2 (ETHYLSULFONYL) 4 (4 FLUOROPHENYL) 5 [4 (METHYLSULFONYL)PHENYL] 1H IMIDAZOLE; 2 (ETHYLSULFONYL) 5 [4 (METHYLSULFONYL)PHENYL] 4 PHENYL 1H IMIDAZOLE; 2 (ETHYLTHIO) 4 (4 FLUOROPHENYL) 5 [4 (METHYLSULFONYL)PHENYL] 1H IMIDAZOLE; 2 (ETHYLTHIO) 5 (4 (METHYLSULFONYL)PHENYL) 4 PHENYL 1H IMIDAZOLE; 2 (METHYLSULFONYL) 5 [4 (METHYLSULFONYL)PHENYL] 4 PHENYL 1H IMIDAZOLE; 4 (4 CHLOROPHENYL) 2 (ETHYLSULFONYL) 5 [4 (METHYLSULFONYL)PHENYL] 1H IMIDAZOLEIMIDAZOLE; 4 (4 CHLOROPHENYL) 2 (ETHYLTHIO) 5 [4 (METHYLSULFONYL)PHENYL] 1H IMIDAZOLE; 4 (4 CHLOROPHENYL) 2 (METHYLSULFONYL) 5 [4 (METHYLSULFONYL)PHENYL] 1H IMIDAZOLE; 4 (4 CHLOROPHENYL) 5 [4 (METHYLSULFONYL)PHENYL] 2 (METHYLTHIO) 1H IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (METHYLSULFONYL) 5 [4 (METHYLSULFONYL)PHENYL] 1H IMIDAZOLE; 4 (4 FLUOROPHENYL) 5 [4 (METHYLSULFONYL)PHENYL] 2 (METHYLTHIO) 1H IMIDAZOLE; 4 ARYL 5 [4 (METHYLSULFONYL)PHENYL] 2 ALKYLSULFONYL 1H IMIDAZOLE DERIVATIVE; 4 ARYL 5 [4 (METHYLSULFONYL)PHENYL] 2 ALKYLTHIO 1H IMIDAZOLE DERIVATIVE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 5 [4 (METHYLSULFONYL)PHENYL] 2 (METHYLTHIO) 4 PHENYL 1H IMIDAZOLE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; ARGININE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IMIDAZOLE DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; HUMANS; IMIDAZOLES; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875711910     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.058     Document Type: Article

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