Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: Asymmetric synthesis, neuroactivity, and structural characterization

Journal of Medicinal Chemistry

Volumn 56, Issue 6, 2013, Pages 2283-2293

  Juknaitě, Lina ^d   Sugamata, Yutaro ^a   Tokiwa, Kazuya ^a   Ishikawa, Yuichi ^a   Takamizawa, Satoshi ^a   Eng, Andrew ^b   Sakai, Ryuichi ^c   Pickering, Darryl S ^d   Frydenvang, Karla ^d   Swanson, Geoffrey T ^b   Kastrup, Jette S ^d   Oikawa, Masato ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b NORTHWESTERN UNIVERSITY   (United States)

^c HOKKAIDO UNIVERSITY   (Japan)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR ANTAGONIST; GLUTAMIC ACID; IKM 159; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASYMMETRIC SYNTHESIS; CELL ASSAY; CONTROLLED STUDY; CRYSTALLIZATION; DRUG ACTIVITY; DRUG BINDING SITE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; NERVE CELL; NONHUMAN; RACEMIC MIXTURE; RAT;

ANIMALS; BENZOFURANS; CHEMISTRY TECHNIQUES, SYNTHETIC; ISOMERISM; LIGANDS; MICE; MODELS, MOLECULAR; NEURONS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PYRROLIDINONES; RECEPTORS, AMPA;

EID: 84875701435     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301590z     Document Type: Article

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