α-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction

American Journal of Physiology - Renal Physiology

Volumn 290, Issue 2, 2006, Pages

  Li, Chunling ^a   Shi, Yimin ^a   Wang, Weidong ^a   Sardeli, Chrysanthi ^a   Kwon, Tae Hwan ^a,b   Thomsen, Klaus ^c   Jonassen, Thomas ^d   Djurhuus, Jens Christian ^a   Knepper, Mark A ^e   Nielsen, Søren ^a   Frøkiær, Jørgen ^a,c  

^a AARHUS UNIVERSITY   (Denmark)

^b Kyungpook National University School of Medicine   (South Korea)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e Laboratory of Kidney and Electrolyte Metabolism NHBLI   (United States)

Author keywords

Sodium pump; Urinary concentrating defect; Urinary tract obstruction; Water channels

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALPHA INTERMEDIN; AQUAPORIN; AQUAPORIN 2; AQUAPORIN 3; HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME REGULATION; GLOMERULUS FILTRATION RATE; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; KIDNEY BLOOD FLOW; KIDNEY PLASMA FLOW; KIDNEY TUBULE FUNCTION; KIDNEY TUBULE NECROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; URETER OBSTRUCTION; ANIMAL; BIOBREEDING RAT; KIDNEY; KIDNEY CORTEX; KIDNEY TUBULE; METABOLISM; ORGAN SIZE; PATHOPHYSIOLOGY; ULTRASTRUCTURE;

ALPHA-MSH; ANIMALS; AQUAPORINS; GLOMERULAR FILTRATION RATE; HORMONES; KIDNEY; KIDNEY CORTEX; KIDNEY TUBULES; MALE; NA(+)-K(+)-EXCHANGING ATPASE; ORGAN SIZE; RATS; RATS, INBRED BB; RENAL PLASMA FLOW; URETERAL OBSTRUCTION;

EID: 33644863741     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00282.2004     Document Type: Article

References (48)

1. Agre P and Nielsen S. The aquaporin family of water channels in kidney. Nephrologie 17: 409-415, 1996.
2. Buerkert J, Head M, and Klahr S. Effects of acute bilateral ureteral obstruction on deep nephron and terminal collecting duct function in the young rat. J Clin Invest 59: 1055-1065, 1977.
3. Catania A and Lipton JM. α-Melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev 14: 564-576, 1993.
4. Catania A and Lipton JM. The neuropeptide α-melanocyte-stimulating hormone: a key component of neuroimmunomodulation. Neuroimmunomodulation 1: 93-99, 1994.
5. Chiao H, Kohda Y, McLeroy P, Craig L, Housini I, and Star RA. α-Melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J Clin Invest 99: 1165-1172, 1997.
6. Chiao H, Kohda Y, McLeroy P, Craig L, Linas S, and Star RA. α-Melanocyte-stimulating hormone inhibits renal injury in the absence of neutrophils. Kidney Int 54: 765-774, 1998.
7. Dal Canton A, Corradi A, Stanziale R, Maruccio G, and Migone L. Glomerular hemodynamics before and after release of 24-hour bilateral ureteral obstruction. Kidney Int 17: 491-496, 1980.
8. DiGiovanni SR, Nielsen S, Christensen EI, and Knepper MA. Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. Proc Natl Acad Sci USA 91: 8984-8988, 1994.
9. Ecelbarger CA, Terris J, Frindt G, Echevarria M, Marples D, Nielsen S, and Knepper MA. Aquaporin-3 water channel localization and regulation in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 269: F663-F672, 1995.
10. Frøkiær J, Christensen BM, Marples D, Djurhuus JC, Jensen UB, Knepper MA, and Nielsen S. Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction. Am J Physiol Renal Physiol 273: F213-F223, 1997.
11. Frøkiær J, Marples D, Knepper MA, and Nielsen S. Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 270: F657-F668, 1996.
12. Hanley MJ and Davidson K. Isolated nephron segments from rabbit models of obstructive nephropathy. J Clin Invest 69: 165-174, 1982.
13. Harris KP, Schreiner GF, and Klahr S. Effect of leukocyte depletion on the function of the postobstructed kidney in the rat. Kidney Int 36: 210-215, 1989.
14. Jaenike JR. The renal functional defect of postobstructive nephropathy. J Clin Invest 51: 2999-3006, 1972.
15. Jo SK, Lee SY, Han SY, Cha DR, Cho WY, Kim HK, and Won NH. α-Melanocyte stimulating hormone (MSH) decreases cyclosporine a induced apoptosis in cultured human proximal tubular cells. J Korean Med Sci 16: 603-609, 2001.
16. Kashgarian M, Biemesderfer D, Caplan M, and Forbush B III. Monoclonal antibody to Na,K-ATPase: immunocytochemical localization along nephron segments. Kidney Int 28: 899-913, 1985.
17. Kimura H and Mujais SK. Cortical collecting duct Na-K pump in obstructive nephropathy. Am J Physiol Renal Fluid Electrolyte Physiol 258: F1320-F1327, 1990.
18. Klahr S. Pathophysiology of obstructive nephropathy. A 1991 update. Semin Nephrol 11: 156-168, 1991.
19. Klahr S. Urinary tract obstruction. In: Disease of the Kidney and Urinary Tract, edited by Schrier RW. Philadelphia, PA: Lippincott Williams & Wilkins, 2001, p. 757-788.
20. Klahr S and Pukerson ML. The pathophysiology of obstructive nephropathy: the role of vasoactive compounds in the hemodynamic and structural abnormalities of the obstructed kidney. Am J Kidney Dis 23: 219-223, 1994.
21. Kohda Y, Chiao H, and Star RA. α-Melanocyte-stimulating hormone and acute renal failure. Curr Opin Nephrol Hypertens 7: 413-417, 1998.
22. Kwon TH, Frøkiær J, Fernandez-Llama P, Knepper MA, and Nielsen S. Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by α-MSH. Am J Physiol Renal Physiol 277: F413-F427, 1999.
23. Lee SY, Jo SK, Cho WY, Kim HK, and Won NH. The effect of α-melanocyte-stimulating hormone on renal tubular cell apoptosis and tubulointerstitial fibrosis in cyclosporine A nephrotoxicity. Transplantation 78: 1756-1764, 2004.
24. Li C, Wang W, Knepper MA, Nielsen S, and Frøkiær J. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Am J Physiol Renal Physiol 284: F1066-F1079, 2003.
25. Li C, Wang W, Kwon TH, Isikay L, Wen JG, Marples D, Djurhuus JC, Stockwell A, Knepper MA, Nielsen S, and Frøkiær J. Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect. Am J Physiol Renal Physiol 281: F163-F171, 2001.
26. Li C, Wang W, Kwon TH, Knepper MA, Nielsen S, and Frøkiær J. Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction. Am J Physiol Renal Physiol 285: F889-F901, 2003.
27. Li C, Wang W, Kwon TH, Knepper MA, Nielsen S, and Frøkiær J. Altered expression of major renal Na transporters in rats with unilateral ureteral obstruction. Am J Physiol Renal Physiol 284: F155-F166, 2003.
28. Lipton JM and Catania A. Mechanisms of antiinflammatory action of the neuroimmunomodulatory peptide α-MSH. Ann NY Acad Sci 840: 373-380, 1998.
29. Marples D, Schroer TA, Ahrens N, Taylor A, Knepper MA, and Nielsen S. Dynein and dynactin colocalize with AQP2 water channels in intracellular vesicles from kidney collecting duct. Am J Physiol Renal Physiol 274: F384-F394, 1998.
30. McDougal WS and Wright FS. Defect in proximal and distal sodium transport in post-obstructive diuresis. Kidney Int 2: 304-317, 1972.
31. Moody TE, Vaughn ED Jr, and Gillenwater JY. Relationship between renal blood flow and ureteral pressure during 18 hours of total unilateral uretheral occlusion. Implications for changing sites of increased renal resistance. Invest Urol 13: 246-251, 1975.
32. Muto S and Asano Y. Electrical properties of the rabbit cortical collecting duct from obstructed kidneys after unilateral ureteral obstruction. Effects of renal decapsulation. J Clin Invest 94: 1846-1854, 1994.
33. Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, and Knepper MA. Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci USA 92: 1013-1017, 1995.
34. Nielsen S, Frøkiær J, Marples D, Kwon TH, Agre P, and Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 82: 205-244, 2002.
35. Petersen JS and Christensen S. Superiority of tetraethylammonium to p-aminohippurate as a marker for renal plasma flow during furosemide diuresis. Ren Physiol 10: 102-109, 1987.
36. Petersen JS, Shalmi M, Lam HR, and Christensen S. Renal response to furosemide in conscious rats: effects of acute instrumentation and peripheral sympathectomy. J Pharmacol Exp Ther 258: 1-7, 1991.
37. Ricardo SD and Diamond JR. The role of macrophages and reactive oxygen species in experimental hydronephrosis. Semin Nephrol 18: 612-621, 1998.
38. Sabolic I, Katsura T, Verbavatz JM, and Brown D. The AQP2 water channel: effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats. J Membr Biol 143: 165-175, 1995.
39. Sarkar A, Sreenivasan Y, and Manna SK. α-Melanocyte-stimulating hormone induces cell death in mast cells: involvement of NF-κB. FEBS Lett 549: 87-93, 2003.
40. Schreiner GF, Harris KP, Purkerson ML, and Klahr S. Immunological aspects of acute ureteral obstruction: immune cell infiltrate in the kidney. Kidney Int 34: 487-493, 1988.
41. Schreiner GF and Kohan DE. Regulation of renal transport processes and hemodynamics by macrophages and lymphocytes. Am J Physiol Renal Fluid Electrolyte Physiol 258: F761-F767, 1990.
42. Sonnenberg H and Wilson DR. The role of the medullary collecting duct in postobstructive diuresis. J Clin Invest 57: 1564-1574, 1976.
43. Spannow J, Thomsen K, Petersen JS, Haugan K, and Christensen S. Influence of renal nerves and sodium balance on the acute antidiuretic effect of bendroflumethiazide in rats with diabetes insipidus. J Pharmacol Exp Ther 282: 1155-1162, 1997.
44. Stone DK, Seldin DW, Kokko JP, and Jacobson HR. Mineralocorticoid modulation of rabbit medullary collecting duct acidification. A sodium-independent effect. J Clin Invest 72: 77-83, 1983.
45. Terris J, Ecelbarger CA, Nielsen S, and Knepper MA. Long-term regulation of four renal aquaporins in rats. Am J Physiol Renal Fluid Electrolyte Physiol 271: F414-F422, 1996.
46. Thomsen K. Lithium clearance as a measure of sodium and water delivery from the proximal tubules. Kidney Int Suppl 28: S10-S16, 1990.
47. Thomsen K and Olesen OV. Relationship between sodium clearance and proximal tubular fluid output in conscious unoperated rats adapted to different dietary sodium contents. Acta Pharmacol Toxicol (Copenh) 59: 242-248, 1986.
48. Yarger WE, Aynedjian HS, and Bank N. A micropuncture study of postobstructive diuresis in the rat. J Clin Invest 51: 625-637, 1972.