The phosphodiesterase 4 inhibitor rolipram protects against cigarette smoke extract-induced apoptosis in human lung fibroblasts

European Journal of Pharmacology

Volumn 706, Issue 1-3, 2013, Pages 76-83

  Park, Jeong Woong ^a   Ryter, Stefan W ^b   Kyung, Sun Young ^a   Lee, Sang Pyo ^a   Jeong, Sung Hwan ^a  

^a Gachon University   (South Korea)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Apoptosis; Chronic obstructive pulmonary disease; Cigarette smoke; PDE4 inhibitor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CASPASE 8; CIGARETTE SMOKE; LIPOCORTIN 5; PHOSPHODIESTERASE IV INHIBITOR; PROTEIN KINASE; ROLIPRAM;

APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CIGARETTE SMOKE EXTRACT-INDUCED APOPTOSIS; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PRIORITY JOURNAL;

APOPTOSIS; CASPASE 3; CASPASE 8; CELL LINE; CELL SURVIVAL; FIBROBLASTS; HUMANS; L-LACTATE DEHYDROGENASE; LUNG; PHOSPHODIESTERASE 4 INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; ROLIPRAM; SMOKE; TOBACCO;

EID: 84875684705     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.02.049     Document Type: Article

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