Gentamicin caused renal injury deeply related to methylglyoxal and Nɛ-(carboxyethyl)lysine (CEL)

Toxicology Letters

Volumn 219, Issue 1, 2013, Pages 85-92

  Li, Yi Chieh ^a   Shih, Yi Min ^a   Lee, Jen Ai ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Aminoglycoside; Gentamicin; Kidney damage; Metformin; Methylglyoxal

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CARBONYL DERIVATIVE; CREATININE; GENTAMICIN; GLUTATHIONE; LYSINE DERIVATIVE; METFORMIN; METHYLGLYOXAL; N EPSILON (CARBOXYETHYL)LYSINE; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY INJURY; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE LEVEL; UREA NITROGEN BLOOD LEVEL;

EID: 84875673835     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.01.024     Document Type: Article

References (34)

1. Aslam M., Raza M.H., Khan N.A., Hasan M., Hasan S.A., Ullah M. Gentamicin induced dose related alterations in lipid levels and lipid peroxidation in central auditory pathway of the rat. Experimental Pathology 1990, 38:165-169.
2. Beisswenger P.J., Drummond K.S., Nelson R.G., Howell S.K., Szwergold B.S., Mauer M. Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress. Diabetes 2005, 54:3274-3281.
3. Beisswenger P.J., Howell S.K., Touchette A.D., Lal S., Szwergold B.S. Metformin reduces systemic methylglyoxal levels in type 2 diabetes. Diabetes 1999, 48:198-202.
4. Bertolaso L., Bindini D., Previati M., Falgione D., Lanzoni I., Parmeggiani A., Vitali C., Corbacella E., Capitani S., Martini A. Gentamicin-induced cytotoxicity involves protein kinase C activation, glutathione extrusion and malondialdehyde production in an immortalized cell line from the organ of corti. Audiology and Neuro-otology 2003, 8:38-48.
5. Chen L.F., Kaye D. Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides. The Medical clinics of North America 2011, 95:819-842. viii-ix.
6. Cuzzocrea S., Mazzon E., Dugo L., Serraino I., Di Paola R., Britti D., De Sarro A., Pierpaoli S., Caputi A., Masini E., Salvemini D. A role for superoxide in gentamicin-mediated nephropathy in rats. European Journal of Pharmacology 2002, 450:67-76.
7. De Broe M.E., Paulus G.J., Verpooten G.A., Roels F., Buyssens N., Wedeen R., Van Hoof F., Tulkens P.M. Early effects of gentamicin, tobramycin, and amikacin on the human kidney. Kidney International 1984, 25:643-652.
8. Drusano G.L., Louie A. Optimization of aminoglycoside therapy. Antimicrobial agents and chemotherapy 2011, 55:2528-2531.
9. El Mouedden M., Laurent G., Mingeot-Leclercq M.P., Taper H.S., Cumps J., Tulkens P.M. Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides. Antimicrobial Agents and Chemotherapy 2000, 44:665-675.
10. El Mouedden M., Laurent G., Mingeot-Leclercq M.P., Tulkens P.M. Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts. Toxicological Sciences: An Official Journal of the Society of Toxicology 2000, 56:229-239.
11. Espinosa-Mansilla A., Duran-Meras I., Canada F.C., Marquez M.P. High-performance liquid chromatographic determination of glyoxal and methylglyoxal in urine by prederivatization to lumazinic rings using in serial fast scan fluorimetric and diode array detectors. Analytical Biochemistry 2007, 371:82-91.
12. Houghton D.C., Plamp C.E., DeFehr J.M., Bennett W.M., Porter G., Gilbert D. Gentamicin and tobramycin nephrotoxicity. A morphologic and functional comparison in the rat. The American Journal of Pathology 1978, 93:137-152.
13. Huang W.J., Tung C.W., Ho C., Yang J.T., Chen M.L., Chang P.J., Lee P.H., Lin C.L., Wang J.Y. Ras activation modulates methylglyoxal-induced mesangial cell apoptosis through superoxide production. Renal Failure 2007, 29:911-921.
14. Kalapos M.P. The tandem of free radicals and methylglyoxal. Chemico-Biological Interactions 2008, 171:251-271.
15. Khan M.R., Badar I., Siddiquah A. Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats. BMC Complementary and Alternative Medicine 2011, 11:113.
16. Lee J.-A., Tsai Y.-C., Chen H.-Y., Wang C.-C., Chen S.-M., Fukushima T., Imai K. Fluorimetric determination of d-lactate in urine of normal and diabetic rats by column-switching high-performance liquid chromatography. Analytica Chimica Acta 2005, 534:185-191.
17. Li J., Li Q.X., Xie X.F., Ao Y., Tie C.R., Song R.J. Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats. European Journal of Pharmacology 2009, 620:97-104.
18. e{open}-(carboxymethyl)lysine: an important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy. Biochemical and Biophysical Research Communications 2012, 423:832-837.
19. Liu B.F., Miyata S., Hirota Y., Higo S., Miyazaki H., Fukunaga M., Hamada Y., Ueyama S., Muramoto O., Uriuhara A., Kasuga M. Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells. Kidney International 2003, 63:947-957.
20. Lopez-Novoa J.M., Quiros Y., Vicente L., Morales A.I., Lopez-Hernandez F.J. New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney International 2011, 79:33-45.
21. Mazzon E., Britti D., De Sarro A., Caputi A.P., Cuzzocrea S. Effect of N-acetylcysteine on gentamicin-mediated nephropathy in rats. European Journal of Pharmacology 2001, 424:75-83.
22. Morales A.I., Detaille D., Prieto M., Puente A., Briones E., Arevalo M., Leverve X., Lopez-Novoa J.M., El-Mir M.Y. Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway. Kidney International 2010, 77:861-869.
23. Nonclercq D., Wrona S., Toubeau G., Zanen J., Heuson-Stiennon J.A., Schaudies R.P., Laurent G. Tubular injury and regeneration in the rat kidney following acute exposure to gentamicin: a time-course study. Renal Failure 1992, 14:507-521.
24. Ota K., Nakamura J., Li W., Kozakae M., Watarai A., Nakamura N., Yasuda Y., Nakashima E., Naruse K., Watabe K., Kato K., Oiso Y., Hamada Y. Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells. Biochemical and Biophysical Research Communications 2007, 357:270-275.
25. Pessoa E.A., Convento M.B., Silva R.G., Oliveira A.S., Borges F.T., Schor N. Gentamicin-induced preconditioning of proximal tubular LLC-PK1 cells stimulates nitric oxide production but not the synthesis of heat shock protein. Brazilian Journal Of Medical And Biological Research=Revista brasileira de pesquisas medicas e biologicas/Sociedade Brasileira de Biofisica [et al] 2009, 42:614-620.
26. Rabbani N., Thornalley P.J. Glyoxalase in diabetes, obesity and related disorders. Seminars in Cell and Developmental Biology 2011, 22:309-317.
27. Rosca M.G., Monnier V.M., Szweda L.I., Weiss M.F. Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal. American Journal of physiology Renal Physiology 2002, 283:F52-F59.
28. Rosca M.G., Mustata T.G., Kinter M.T., Ozdemir A.M., Kern T.S., Szweda L.I., Brownlee M., Monnier V.M., Weiss M.F. Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. American Journal of Physiology: Renal Physiology 2005, 289:F420-F430.
29. Ruggiero-Lopez D., Lecomte M., Moinet G., Patereau G., Lagarde M., Wiernsperger N. Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of advanced glycation end product formation. Biochemical Pharmacology 1999, 58:1765-1773.
30. Sato T., Iwaki M., Shimogaito N., Wu X., Yamagishi S., Takeuchi M. TAGE (toxic AGEs) theory in diabetic complications. Current Molecular Medicine 2006, 6:351-358.
31. Sundin D.P., Sandoval R., Molitoris B.A. Gentamicin inhibits renal protein and phospholipid metabolism in rats: implications involving intracellular trafficking. Journal of the American Society of Nephrology: JASN 2001, 12:114-123.
32. Vamecq J.F., Dessein A.-F., Fontaine M.F., Briand G.F., Porchet N.F., Latruffe N.F., Andreolotti P.F., Cherkaoui-Malki M. Mitochondrial dysfunction and lipid homeostasis. Current Drug Metabolism 2012, 13(10):1388-1400.
33. Vandewalle A., Farman N., Morin J.P., Fillastre J.P., Hatt P.Y., Bonvalet J.P. Gentamicin incorporation along the nephron: autoradiographic study on isolated tubules. Kidney International 1981, 19:529-539.
34. Yamagishi S., Inagaki Y., Okamoto T., Amano S., Koga K., Takeuchi M. Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells. Kidney International 2003, 63:464-473.