Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats

European Journal of Pharmacology

Volumn 620, Issue 1-3, 2009, Pages 97-104

  Li, Jin ^a   Li, Qi xiong ^b   Xie, Xian fei ^b   Ao, Ying ^b   Tie, Chao rong ^a   Song, Ren jie ^b  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Amlodipine; Antioxidation; Gentamicin; Nephrotoxicity; Nifedipine; Nitrendipine

Indexed keywords

AMLODIPINE; CREATININE; DIHYDROPYRIDINE DERIVATIVE; GENTAMICIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; N ACETYL BETA GLUCOSAMINIDASE; NIFEDIPINE; NITRENDIPINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROGEN; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG POTENCY; HISTOPATHOLOGY; KIDNEY PARENCHYMA; KIDNEY TUBULE CELL; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; UREA NITROGEN BLOOD LEVEL;

ACETYLGLUCOSAMINIDASE; AMLODIPINE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOOD UREA NITROGEN; CALCIUM CHANNEL BLOCKERS; CREATINE; GENE EXPRESSION REGULATION; GENTAMICINS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; KIDNEY TUBULES; MALE; MALONDIALDEHYDE; NIFEDIPINE; NITRENDIPINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEINURIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 70349122494     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.08.021     Document Type: Article

References (36)

1. Ali B.H. Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research. Food Chem. Toxicol. 41 (2003) 1447-1452
2. Allanore Y., Borderie D., Lemaréchal H., Ekindjian O.G., and Kahan A. Acute and sustained effects of dihydropyridine-type calcium channel antagonists on oxidative stress in systemic sclerosis. Am. J. Med. 116 (2004) 595-600
3. Allanore Y., Borderie D., Périanin A., Lemaréchal H., Ekindjian O.G., and Kahan A. Nifedipine protects against superoxide anion overproduction by monocytes from patients with systemic sclerosis. Arthritis Res. Ther. 7 (2005) 93-100
4. Bakris G.L., Weir M.R., Secic M., Campbell B., and Weis-McNulty A. Differential effects of calcium antagonist subclasses on markers of nephropathy progression. Kidney Int. 65 (2004) 1991-2002
5. Berkels R., Breitenbach T., Bartels H., Taubert D., Rosenkranz A., Klaus W., and Roesen R. Different antioxidative potencies of dihydropyridine calcium channel modulators in various models. Vascular harmacology 42 (2005) 145-152
6. Beutler E., Durom O., and Kelly B.M. Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 61 (1963) 882-888
7. Chander V., and Chopra K. Nifedipine attenuates changes in nitric oxide levels, renal oxidative stress, and nephrotoxicity induced by cyclosporine. Renal Fail. 27 (2005) 441-450
8. Cominacini L., Pasini A.F., Garbin U., Pastorino A.M., Davoli A., Nava C., Campagnola M., Rossato P., and Cascioa V.L. Antioxidant activity of different dihydropyridines. Biochem. Biophys. Res. Commun. 302 (2003) 679-684
9. Cuzzocrea S., Mazzon E., Dugo L., Serraino I., Di Paola R., Britti D., De Sarro A., Pierpaoli S., Caputi A., Masini E., and Salvemini D. A role for superoxide in gentamicin-mediated nephropathy in rats. Eur. J. Pharmacol. 450 (2002) 67-76
10. Duan S.B., Liu F.Y., Luo J.A., Wu H.W., Liu R.H., Peng Y.M., and Yang X.L. Nephrotoxicity of high- and low-osmolar contrast media. The protective role of amlodipine in a rat model. Acta. Radiol. 41 (2000) 503-507
11. Epstein M., and Hollenberg N.K. Effects of the angiotensin-1receptor blocker valsartan compared with amlodipine on renal hemodynamics. Am. J. Hypertens. 17 (2004) 638-639
12. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The fi{ligature}rst enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130-7139
13. Hayashi K., Nagahama T., Oka K., Epstein M., and Saruta T. Disparate effects of calcium antagonists on renal microcirculation. Hypertens. Res. 19 (1996) 31-36
14. Hua G., and Ya-wei Z. Inhibitory effect of picroside II on hepatocyte apoptosis. Acta Pharmacol. Sin. 26 (2005) 729-736
15. Karahan I., Atessahin A., Yilmaz S., Ceribasi A.O., and Sakin F. Protective effect of lycopene on gentamicin induced oxidative stress and nephrotoxicity in rats. Toxicology 215 (2005) 198-204
16. Kimura K., Suzuki N., Ohba S., Mise N., Miyashita K., Tojo A., Goto A., and Omata M. Effects of amlodipine, a calcium channel blocker on rat renal arterioles. Curr. Ther. Res. 58 (1997) 375-380
17. Laura G., Sánchez L., Gerardo G., Alexis B., Fabiola J., Jaime H.A., and Norma A.B. Nifedipine Prevents Changes in Nitric Oxide Synthase mRNA Levels Induced by Cyclosporine. Hypertension 36 (2000) 642-647
18. Liu L.L., Li Q.X., Xix L., Li J., and Shao L. Differential effects of dihydropyridine calcium antagonists on doxorubicin-induced nephrotoxicity in rats. Toxicology 231 (2007) 81-90
19. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
20. Luciano C., Anna F.P., Ulisse G., Antonio P.M., Anna D., Cristina N., Mario C., Paolo R., and CASCIO L.V. Antioxidant activity of different dihydropyridines. Biochem. Biophys. Res. Commun. 302 (2003) 679-684
21. Marklund S., and Marklund G. Involvement of the superoxide anion radical in the autooxidation of pyrogallol and convenient assay for superoxide dismutase. Eur. J. Biochem. 47 (1974) 469-474
22. Martínez-Salgado C., Eleno N., Morales A., Pérez-Barriocanal F., Arévalo M., and López-Novoa J.M. Gentamicin treatment induces simultaneous mesangial proliferation and apoptosis in rats. Kidney Int. 65 (2004) 2161-2171
23. Martínez-Salgado C., López-Hernández F.J., and López-Novoa J.M. Glomerular nephrotoxicity of aminoglycosides. Toxicol. Appl. Pharmacol. 223 (2007) 86-98
24. Mason R.P., Walter M.F., Trumbore M.W., Olmstead E.G., and Mason P.E. Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine. J. Mol. Cell. Cardiol. 31 (1999) 275-281
25. Matas J., Rumboldt Z., and Karelovic D. Renoprotective role of nifedipine during gentamicin therapy: randomized controlled trial. Croatian Medical Journal 41 (2000) 417-422
26. Nagai J., and Takano M. Molecular Aspects of Renal Handling of Aminoglycosides and Strategies for Preventing the Nephrotoxicity. Drug Metabolism and Pharmacokinetics 19 (2004) 159-170
27. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351-358
28. Pedraza-Chaverri J., Gonzalez-Orozco A.E., Maldonado P.D., Barrera D., Medina-Campos O.N., and Hernandez-Pando R. Diallyl disulfi{ligature}de ameliorates gentamicin-induced oxidative stress and nephropathy in rats. Eur. J. Pharmacol. 473 (2003) 71-78
29. Price R.J. Urinary N-acetyl-β-d-glucosaminidase (NAG) as an indicator of renal disease. Curr. Probl. Clin. Biochem. 9 (1979) 150-163
30. Rodríguez-López A., Flores O., Arévalo M., and López-Novoa J.M. Glomerular cell proliferation and apoptosis in the early phase of renal damage in uninephrectomized spontaneously hypertensive rats. Kidney Int. 54 (1998) 36-40
31. Salant D.J., and Ybulsky A.V. Experimental glomerulonephritis. Meth. Enzymol. 162 (1988) 421-461
32. Stuehr D.J., Know N.S., and Gross S.S. Synthesis of nitrogen oxides from l-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochem. Biophys. Res. Commun. 161 (1989) 420-426
33. Tobe S. Update on calcium antagonists and the kidney. Curr. Opin. Nephrol. Hypertens. 12 (2003) 309-315
34. Valdivielso J.M., and Blantz R.C. Acute renal failure: is nitric oxide the bad guy?. Antioxid Redox Signal. 4 (2002) 925-934
35. Walker P.D., Barri Y., and Shah S.V. Oxidant mechanisms in gentamicin nephrotoxicity. Ren. Fail. 21 (1999) 433-442
36. Zurovsky Y., and Haber C. Antioxidants attenuate endotoxin-gentamicin induced acute renal failure in rats. Scand. J. Urol. Nephrol. 29 (1995) 147-154