Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 24, 2006, Pages 6281-6287

  Chen, Fengming ^a   Hancock, Chad N ^b   Macias, Alba T ^a   Joh, Joseph ^a   Still, Kimberly ^c   Zhong, Shijun ^a   MacKerell Jr , Alexander D ^a   Shapiro, Paul ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c STEVENSON UNIVERSITY   (United States)

Author keywords

Computer aided drug design; Docking domains; Drug development; Extracellular signal regulated kinase

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR;

ARTICLE; CANCER CELL; CARCINOMA CELL; CELL ACTIVATION; CELL PROLIFERATION; COMPUTER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IC 50; MOLECULAR DYNAMICS; RECEPTOR BINDING; UTERINE CERVIX CARCINOMA;

ADENOSINE TRIPHOSPHATE; BINDING SITES; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS;

EID: 33750826362     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.038     Document Type: Article

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