Estrogen defines the dynamics and destination of transactivated EGF receptor in breast cancer cells: Role of S1P3 receptor and Cdc42

Experimental Cell Research

Volumn 319, Issue 4, 2013, Pages 455-465

  Sukocheva, O ^a   Wadham, C ^b   Xia, P ^b  

^a FLINDERS UNIVERSITY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Breast cancer; Cdc42; EGFR; Estrogen; Sphingosine 1 phosphate

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; PROTEIN CDC42; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 1; ESTRADIOL;

ACTIN FILAMENT; ARTICLE; BIOTINYLATION; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER SURVIVAL; CELL MEMBRANE; CELL STRAIN MCF 7; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTERNALIZATION; INTRACELLULAR SIGNALING; LIGAND BINDING; LYSOSOME; METASTASIS POTENTIAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; TRANSACTIVATION; BREAST TUMOR; CARCINOMA; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; KINETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT; TRANSCRIPTION INITIATION; TUMOR CELL CULTURE;

BREAST NEOPLASMS; CARCINOMA; CDC42 GTP-BINDING PROTEIN; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KINETICS; PROTEIN TRANSPORT; PROTEOLYSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, LYSOSPHINGOLIPID; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION; TUMOR CELLS, CULTURED;

MLCS; MLOWN;

EID: 84875519602     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.10.014     Document Type: Article

References (34)

1. Blume-Jensen P., Hunter T. Oncogenic kinase signaling. Nature 2001, 411:355-365.
2. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000, 103:211.
3. Sigismund S., Argenzio E., Tosoni D., Cavallaro E., Polo S., Di Fiore P.P. Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev. Cell 2008, 15:209-219.
4. Sorkin, Von Zastrow M. Signal transduction and endocytosis: close encounters of many kinds. Nat. Rev. Mol. Cell Biol. 2002, 3:600-614.
5. Di Fiore P.P., Gill G.N. Endocytosis and mitogenic signaling. Curr. Opin. Cell Biol. 1999, 11:483-488.
6. Wu W.J., Tu S., Cerione R.A. Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell 2003, 114:715-725.
7. Thogersen V.B., Sorensen B.S., Poulsen S.S., Orntoft T.F., Wolf H., Nexo E. A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients. Cancer Res. 2001, 61:6227-6233.
8. Roepstorff K., Grandal M.V., Henriksen L., Knudsen S.L., Lerdrup M., Grøvdal L., Willumsen B.M., van Deurs B. Differential effects of EGFR ligands on endocytic sorting of the receptor. Traffic 2009, 10:1115-1127.
9. Tanimoto V.B., Lungu A.O., Berk B.C. Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Circ. Res. 2004, 94:1050-1058.
10. Sukocheva O., Wadham C., Holmes A., Albanese N., Verrier E., Feng F., Bernal A., Derian C.K., Ullrich A., Vadas M.A., Xia P. Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. J. Cell Biol. 2006, 173:301-310.
11. Nobes C.D., Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 1999, 144:1235-1244.
12. Kroschewski R., Hall A., Mellman I. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells. Nat. Cell Biol. 1999, 1:8-13.
13. Camera P., Da Silva J.S., Griffiths G., Giuffrida M.G., Ferrara L., Schubert V., Imarisio S., Silengo L., Dotti C.G., Di Cunto F. Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation. Nat. Cell Biol. 2003, 5:1071-1078.
14. Shen H., Ferguson S.M., Dephoure N., Park R., Yang Y., Volpicelli-Daley L., Gygi S., Schlessinger J., De Camilli P. Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol. Biol. Cell. 2011, 22:493-502.
15. Tu S., Cerione R.A. Cdc42 is a substrate for caspases and influences Fas-induced apoptosis. J. Biol. Chem. 2001, 276:19656-19663.
16. Hirsch D.S., Wu W.J. Cdc42: an effector and regulator of ErbB1 as a strategic target in breast cancer therapy. Expert Rev. Anticancer Ther. 2007, 7:147-157.
17. Takuwa Y. Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. Biochim. Biophys. Acta 2002, 1582:112-120.
18. Mandala S., Hajdu R., Bergstrom J., Quackenbush E., Xie J., Milligan J., Thornton R., Shei G.J., Card D., Keohane C., Rosenbach M., Hale J., Lynch C.L., Rupprecht K., Parsons W., Rosen H. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002, 296:346-349.
19. Sanchez T., Hla T. Structural and functional characteristics of S1P receptors. J. Cell Biochem. 2004, 92:913-922.
20. Siehler S., Manning D.R. Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. Biochim. Biophys. Acta 2002, 1582:94-99.
21. Sukocheva O., Wang L., Albanese N., Pitson S., Vadas M., Xia P. Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Mol. Endocrinol. 2003, 17:2002-2012.
22. Lladó F., Tebar M., Calvo J., Moretó A., Sorkin C. Enrich, protein kinase C delta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. Mol. Biol. Cell 2004, 15:4877-4891.
23. Volpicelli L.A., Lah J.J., Levey A.I. Rab5-dependent trafficking of the m4 muscarinic acetylcholine receptor to the plasma membrane, early endosomes, and multivesicular bodies. J. Biol. Chem. 2001, 276:47590-47598.
24. Osmani N., Peglion F., Chavrier P., Etienne-Manneville S. Cdc42 localization and cell polarity depend on membrane traffic. J. Cell Biol. 2010, 191:1261-1269.
25. Haugh J.M. Localization of receptor-mediated signal transduction pathways: the inside story. Mol. Interv. 2002, 2:292-307.
26. Barbieri M.A., Fernandez-Pol S., Hunker C., Horazdovsky B.H., Stahl P.D. Role of rab5 in EGF receptor-mediated signal transduction. Eur. J. Cell Biol. 2004, 83:305-314.
27. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., Parsons J.T., Horwitz A.R. Cell migration: integrating signals from front to back. Science 2003, 302:1704-1709.
28. Ridley A.J. Rho proteins and cancer. Breast Cancer Res. Treat. 2004, 84:13-19.
29. Jaffe A.B., Hall A. Rho GTPases: biochemistry and biology. Ann. Rev. Cell Dev. Biol. 2005, 21:247-269.
30. Chou J., Burke N.A., Iwabu A., Watkins S.C., Wells A. Directional motility induced by epidermal growth factor requires Cdc42. Exp. Cell Res. 2003, 287:47-56.
31. Acconcia F., Barnes C.J., Kumar R. Estrogen and tamoxifen induce cytoskeletal remodeling and migration in endometrial cancer cells. Endocrinology 2006, 147:1203-1212.
32. Azios N.G., Krishnamoorthy L., Harris M., Cubano L.A., Cammerz M., Dharmawardhan S.F. Estrogen and resveratrol regulate Rac and Cdc42 Signaling to the actin cytoskeleton of metastatic breast cancer cells. Neoplasia 2007, 9:147-158.
33. Kim S.H., Li Z., Sacks D.B. E-cadherin-mediated cell-cell attachment activates Cdc42. J. Biol. Chem. 2000, 275:36999-37005.
34. Sukocheva O.A., Wang L., Verrier E., Vadas M.A., Xia P. Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology 2009, 150:4484-4492.