-
1
-
-
70049097160
-
Letairis (Ambrisentan) Tablets: Medical Review(s)
-
Accessed March 20, 2008
-
US Food and Drug Administration. Center for drug evaluation and research. Letairis (Ambrisentan) Tablets: Medical Review(s). http://www.fda.gov/cder/foi/nda/2007/022081s000TOC.htm (Accessed March 20, 2008).
-
-
-
-
2
-
-
46449124591
-
Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
-
Galiè N, Olschewski H, Oudiz RJ, Torres F, Frost A, Ghofrani HA, et al.Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Circulation 2008;117(23):3010-9.
-
(2008)
Circulation
, vol.117
, Issue.23
, pp. 3010-3019
-
-
Galiè, N.1
Olschewski, H.2
Oudiz, R.J.3
Torres, F.4
Frost, A.5
Ghofrani, H.A.6
-
3
-
-
85048506722
-
US Food and Drug Administration. Center for drug evaluation and research. Letairis (Ambrisentan) Tablets: Medical Review(s)
-
Accessed March 20, 2008
-
US Food and Drug Administration. Center for drug evaluation and research. Letairis (Ambrisentan) Tablets: Medical Review(s). http://www.fda.gov/cder/foi/nda/2007/022081s000TOC.htm (Accessed March 20, 2008).
-
-
-
-
4
-
-
46449124591
-
Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
-
Galiè N, Olschewski H, Oudiz RJ, Torres F, Frost A, Ghofrani HA, et al.Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Circulation 2008;117(23):3010-9.
-
(2008)
Circulation
, vol.117
, Issue.23
, pp. 3010-3019
-
-
Galiè, N.1
Olschewski, H.2
Oudiz, R.J.3
Torres, F.4
Frost, A.5
Ghofrani, H.A.6
-
5
-
-
77950820615
-
Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies
-
Barst RJ, Mubarak KK, Machado RF, Ataga KI, Benza RL, Castro O, et al.Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies. British Journal of Haematology 2010;149(3):426-35.
-
(2010)
British Journal of Haematology
, vol.149
, Issue.3
, pp. 426-435
-
-
Barst, R.J.1
Mubarak, K.K.2
Machado, R.F.3
Ataga, K.I.4
Benza, R.L.5
Castro, O.6
-
6
-
-
85048466536
-
-
Tablets: Medical Review(s) Accessed March 20, 2008
-
US Food and Drug Administration. Center for drug evaluation and research.Tracleer (Bosentan) Tablets: Medical Review(s). http://www.fda.gov/cder/foi/nda/2001/21-290_Tracleer.htm Vol. Accessed March 20, 2008.
-
Center for drug evaluation and research.Tracleer (Bosentan)
-
-
-
7
-
-
0037149718
-
Bosentan therapy for pulmonary arterial hypertension
-
Rubin LJ, Badesch DB, Barst RJ, Galiè N, Black CM, Keogh A. Bosentan therapy for pulmonary arterial hypertension. The New England Journal of Medicine 2002;346(12):896-03.
-
(2002)
The New England Journal of Medicine
, vol.346
, Issue.12
, pp. 896-903
-
-
Rubin, L.J.1
Badesch, D.B.2
Barst, R.J.3
Galiè, N.4
Black, C.M.5
Keogh, A.6
-
8
-
-
85048465766
-
Center for drug evaluation and research.Tracleer (Bosentan) Tablets: Medical Review(s)
-
Accessed March 20, 2008
-
US Food and Drug Administration. Center for drug evaluation and research.Tracleer (Bosentan) Tablets: Medical Review(s). http://www.fda.gov/cder/foi/nda/2001/21-290_Tracleer.htm (Accessed March 20, 2008).
-
-
-
-
9
-
-
4544383466
-
Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2
-
Humbert M, Barst RJ, Robbins IM, Channick RN, Galiè N, Boonstra A, et al.Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. The European Respiratory Journal 2004;24(3):353-9.
-
(2004)
The European Respiratory Journal
, vol.24
, Issue.3
, pp. 353-359
-
-
Humbert, M.1
Barst, R.J.2
Robbins, I.M.3
Channick, R.N.4
Galiè, N.5
Boonstra, A.6
-
10
-
-
33746206340
-
Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study
-
Galiè N, Beghetti M, Gatzoulis MA, Granton J, Berger RM, Lauer A, et al.Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study. Circulation 2006;114(1):48-54.
-
(2006)
Circulation
, vol.114
, Issue.1
, pp. 48-54
-
-
Galiè, N.1
Beghetti, M.2
Gatzoulis, M.A.3
Granton, J.4
Berger, R.M.5
Lauer, A.6
-
11
-
-
0036263877
-
complete results of the first randomized, placebo-controlled study of bosentan, a dual endothelin receptor antagonist, in pulmonary arterial hypertension
-
Badesch DB, Bodin F, Channick RN, Frost A, Rainisio M, Robbins IM, et al.complete results of the first randomized, placebo-controlled study of bosentan, a dual endothelin receptor antagonist, in pulmonary arterial hypertension. Current Therapeutic Research, Clinical & Experimental 2002;63(4):227-46.
-
(2002)
Current Therapeutic Research, Clinical & Experimental
, vol.63
, Issue.4
, pp. 227-246
-
-
Badesch, D.B.1
Bodin, F.2
Channick, R.N.3
Frost, A.4
Rainisio, M.5
Robbins, I.M.6
-
12
-
-
0035818316
-
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study
-
Channick RN, Simonneau G, Sitbon O, Robbins IM, Frost A, Tapson VF. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet 2001;358(9288):1119-23.
-
(2001)
Lancet
, vol.358
, Issue.9288
, pp. 1119-1123
-
-
Channick, R.N.1
Simonneau, G.2
Sitbon, O.3
Robbins, I.M.4
Frost, A.5
Tapson, V.F.6
-
13
-
-
45249119855
-
Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial
-
Galiè N, Rubin L, Hoeper M, Jansa P, Al-Hiti H, Meyer G, et al.Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet 2008;371(9630):2093-100.
-
(2008)
Lancet
, vol.371
, Issue.9630
, pp. 2093-2100
-
-
Galiè, N.1
Rubin, L.2
Hoeper, M.3
Jansa, P.4
Al-Hiti, H.5
Meyer, G.6
-
14
-
-
0344837813
-
Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension
-
Galiè N, Hinderliter AL, Torbicki A, Fourme T, Simonneau G, Pulido T, et al.Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension. Journal of the American College of Cardiology 2003;41(8):1380-6.
-
(2003)
Journal of the American College of Cardiology
, vol.41
, Issue.8
, pp. 1380-1386
-
-
Galiè, N.1
Hinderliter, A.L.2
Torbicki, A.3
Fourme, T.4
Simonneau, G.5
Pulido, T.6
-
15
-
-
21144437393
-
Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study
-
Wilkins MR, Paul GA, Strange JW, Tunariu N, Gin-Sing W, Banya WA, et al.Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study. American Journal of Respiratory & Critical Care Medicine 2005;171(11):1292-7.
-
(2005)
American Journal of Respiratory & Critical Care Medicine
, vol.171
, Issue.11
, pp. 1292-1297
-
-
Wilkins, M.R.1
Paul, G.A.2
Strange, J.W.3
Tunariu, N.4
Gin-Sing, W.5
Banya, W.A.6
-
16
-
-
85048470837
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report
-
(Accessed March 22, 2008)
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report. www.emea.europa.eu/humandocs/PDFs/EPAR/thelin/H-679-en6.pdf (Accessed March 22, 2008).
-
-
-
-
17
-
-
85048479515
-
Therapeutic Goods Administration (TGA), Australia. Public Summary Documents by Product: Thelin
-
Accessed April 25, 2008
-
Therapeutic Goods Administration (TGA), Australia. Public Summary Documents by Product: Thelin. http://www.health.gov.au/internet/main/publishing.nsf/Content/pbac-psd-sitaxentan-sodium-july07 (Accessed April 25, 2008).
-
-
-
-
18
-
-
10744230817
-
Sitaxsentan therapy for pulmonary arterial hypertension
-
Barst RJ, Langleben D, Frost E, Horn EM, Oudiz R, Shapiro S, et al.Sitaxsentan therapy for pulmonary arterial hypertension. Amercian Journal of Respiratory and Critical Care Medicine 2004;169:441-7.
-
(2004)
Amercian Journal of Respiratory and Critical Care Medicine
, vol.169
, pp. 441-447
-
-
Barst, R.J.1
Langleben, D.2
Frost, E.3
Horn, E.M.4
Oudiz, R.5
Shapiro, S.6
-
19
-
-
85048514940
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report
-
Accessed March 22
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report. www.emea.europa.eu/humandocs/PDFs/EPAR/thelin/H-679-en6.pdf Accessed March 22, 2008.
-
(2008)
-
-
-
20
-
-
10744230817
-
Sitaxsentan therapy for pulmonary arterial hypertension
-
Barst RJ, Langleben D, Frost E, Horn EM, Oudiz R, Shapiro S, et al.Sitaxsentan therapy for pulmonary arterial hypertension. Amercian Journal of Respiratory and Critical Care Medicine 2004;169:441-7.
-
(2004)
Amercian Journal of Respiratory and Critical Care Medicine
, vol.169
, pp. 441-447
-
-
Barst, R.J.1
Langleben, D.2
Frost, E.3
Horn, E.M.4
Oudiz, R.5
Shapiro, S.6
-
21
-
-
85048470837
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report
-
(Accessed March 22, 2008)
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report. www.emea.europa.eu/humandocs/PDFs/EPAR/thelin/H-679-en6.pdf (Accessed March 22, 2008).
-
-
-
-
22
-
-
10744230817
-
Sitaxsentan therapy for pulmonary arterial hypertension
-
Barst RJ, Langleben D, Frost E, Horn EM, Oudiz R, Shapiro S, et al.Sitaxsentan therapy for pulmonary arterial hypertension. Amercian Journal of Respiratory and Critical Care Medicine 2004;169:441-7.
-
(2004)
Amercian Journal of Respiratory and Critical Care Medicine
, vol.169
, pp. 441-447
-
-
Barst, R.J.1
Langleben, D.2
Frost, E.3
Horn, E.M.4
Oudiz, R.5
Shapiro, S.6
-
23
-
-
85048470837
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report
-
(Accessed March 22, 2008)
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report. www.emea.europa.eu/humandocs/PDFs/EPAR/thelin/H-679-en6.pdf (Accessed March 22, 2008).
-
-
-
-
24
-
-
85048479515
-
Therapeutic Goods Administration (TGA), Australia. Public Summary Documents by Product: Thelin
-
Accessed April 25, 2008
-
Therapeutic Goods Administration (TGA), Australia. Public Summary Documents by Product: Thelin. http://www.health.gov.au/internet/main/publishing.nsf/Content/pbac-psd-sitaxentan-sodium-july07 (Accessed April 25, 2008).
-
-
-
-
25
-
-
33646255654
-
Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan
-
Barst RJ, Langleben D, Badesch D, Frost A, Lawrence EC, Shapiro S, et al.Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. Journal of the American College of Cardiology 2006;47(10):2049-56.
-
(2006)
Journal of the American College of Cardiology
, vol.47
, Issue.10
, pp. 2049-2056
-
-
Barst, R.J.1
Langleben, D.2
Badesch, D.3
Frost, A.4
Lawrence, E.C.5
Shapiro, S.6
-
26
-
-
85048470837
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report
-
(Accessed March 22, 2008)
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report. www.emea.europa.eu/humandocs/PDFs/EPAR/thelin/H-679-en6.pdf (Accessed March 22, 2008).
-
-
-
-
27
-
-
85048479515
-
Therapeutic Goods Administration (TGA), Australia. Public Summary Documents by Product: Thelin
-
Accessed April 25, 2008
-
Therapeutic Goods Administration (TGA), Australia. Public Summary Documents by Product: Thelin. http://www.health.gov.au/internet/main/publishing.nsf/Content/pbac-psd-sitaxentan-sodium-july07 (Accessed April 25, 2008).
-
-
-
-
28
-
-
33646255654
-
Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan
-
Barst RJ, Langleben D, Badesch D, Frost A, Lawrence EC, Shapiro S, et al.Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. Journal of the American College of Cardiology 2006;47(10):2049-56.
-
(2006)
Journal of the American College of Cardiology
, vol.47
, Issue.10
, pp. 2049-2056
-
-
Barst, R.J.1
Langleben, D.2
Badesch, D.3
Frost, A.4
Lawrence, E.C.5
Shapiro, S.6
-
29
-
-
85048470837
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report
-
(Accessed March 22, 2008)
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report. www.emea.europa.eu/humandocs/PDFs/EPAR/thelin/H-679-en6.pdf (Accessed March 22, 2008).
-
-
-
-
30
-
-
85048479515
-
Therapeutic Goods Administration (TGA), Australia. Public Summary Documents by Product: Thelin
-
Accessed April 25, 2008
-
Therapeutic Goods Administration (TGA), Australia. Public Summary Documents by Product: Thelin. http://www.health.gov.au/internet/main/publishing.nsf/Content/pbac-psd-sitaxentan-sodium-july07 (Accessed April 25, 2008).
-
-
-
-
31
-
-
33646255654
-
Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan
-
Barst RJ, Langleben D, Badesch D, Frost A, Lawrence EC, Shapiro S, et al.Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. Journal of the American College of Cardiology 2006;47(10):2049-56.
-
(2006)
Journal of the American College of Cardiology
, vol.47
, Issue.10
, pp. 2049-2056
-
-
Barst, R.J.1
Langleben, D.2
Badesch, D.3
Frost, A.4
Lawrence, E.C.5
Shapiro, S.6
-
32
-
-
85048470837
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report
-
(Accessed March 22, 2008)
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report. www.emea.europa.eu/humandocs/PDFs/EPAR/thelin/H-679-en6.pdf (Accessed March 22, 2008).
-
-
-
-
33
-
-
85048470837
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report
-
(Accessed March 22, 2008)
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report. www.emea.europa.eu/humandocs/PDFs/EPAR/thelin/H-679-en6.pdf (Accessed March 22, 2008).
-
-
-
-
34
-
-
85048470837
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report
-
(Accessed March 22, 2008)
-
European Medicines Agency. EPARs for authorised medicinal products for human use: Thelin. European Public Assessment Report. www.emea.europa.eu/humandocs/PDFs/EPAR/thelin/H-679-en6.pdf (Accessed March 22, 2008).
-
-
-
-
35
-
-
77950820615
-
Exercise capacity and haemodynamics inpatients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies
-
Barst RJ, Mubarak KK, Machado RF, Ataga KI, Benza RL, Castro O, et al.Exercise capacity and haemodynamics inpatients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies. British Journal of Haematology 2010;149(3):426-35.
-
(2010)
British Journal of Haematology
, vol.149
, Issue.3
, pp. 426-435
-
-
Barst, R.J.1
Mubarak, K.K.2
Machado, R.F.3
Ataga, K.I.4
Benza, R.L.5
Castro, O.6
-
36
-
-
79955845135
-
Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hypertension
-
Barst RJ, Oudiz RJ, Beardsworth A, Brundage BH, Simonneau G, Ghofrani HA, et al.Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hypertension. Journal of Heart & Lung Transplantation 2011;30(6):632-43.
-
(2011)
Journal of Heart & Lung Transplantation
, vol.30
, Issue.6
, pp. 632-643
-
-
Barst, R.J.1
Oudiz, R.J.2
Beardsworth, A.3
Brundage, B.H.4
Simonneau, G.5
Ghofrani, H.A.6
-
37
-
-
33846247928
-
Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan
-
Benza RL, Mehta S, Keogh A, Lawrence EC, Oudiz RJ, Barst RJ. Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007;26(1):63-9.
-
(2007)
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
, vol.26
, Issue.1
, pp. 63-69
-
-
Benza, R.L.1
Mehta, S.2
Keogh, A.3
Lawrence, E.C.4
Oudiz, R.J.5
Barst, R.J.6
-
38
-
-
85048458328
-
Evaluation of the effect of ambrisentan on digital microvascular flow in patients with systemic sclerosis using laser Doppler perfusion imaging
-
Bose N, Bena JF, Trunick CM, Bork DJ, Krishnan G, Petrich J, et al.Evaluation of the effect of ambrisentan on digital microvascular flow in patients with systemic sclerosis using laser Doppler perfusion imaging. Arthritis and Rheumatism 2009;62(Suppl 10):574.
-
(2009)
Arthritis and Rheumatism
, vol.62
, pp. 574
-
-
Bose, N.1
Bena, J.F.2
Trunick, C.M.3
Bork, D.J.4
Krishnan, G.5
Petrich, J.6
-
39
-
-
85048476474
-
Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma
-
Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma. http://clinicaltrials.gov/ct2/show/NCT00070590.
-
-
-
-
40
-
-
38049089932
-
Mutual pharmacokinetic interactions between steady-state bosentan and sildenafil
-
Burgess G, Hoogkamer H, Collings L, Dingemanse J. Mutual pharmacokinetic interactions between steady-state bosentan and sildenafil. European Journal of Clinical Pharmacology 2008;64(1):43-50.
-
(2008)
European Journal of Clinical Pharmacology
, vol.64
, Issue.1
, pp. 43-50
-
-
Burgess, G.1
Hoogkamer, H.2
Collings, L.3
Dingemanse, J.4
-
41
-
-
70049107697
-
No clinical interaction between sitaxsentan and sildenafil [Abstract]
-
May 20-25; San Diego, California. : [A57] [Poster: K70]
-
Coyne TC, Garces PC, Kramer W. No clinical interaction between sitaxsentan and sildenafil [Abstract]. American Thoracic Society 2005 International Conference; May 20-25; San Diego, California. 2005:[A57] [Poster: K70].
-
(2005)
American Thoracic Society 2005 International Conference
-
-
Coyne, T.C.1
Garces, P.C.2
Kramer, W.3
-
42
-
-
84872194734
-
Multicentered trial of tezosentan in cardiac surgery
-
Denault A. Multicentered trial of tezosentan in cardiac surgery. Canadian Journal of Anesthesia 2010;57(Supplement 1):S227.
-
(2010)
Canadian Journal of Anesthesia
, vol.57
, pp. S227
-
-
Denault, A.1
-
43
-
-
80051475258
-
Chronic selective endothelin a receptor antagonism reduces serum uric acid in hypertensive chronic kidney disease
-
Dhaun N, Johnston NR, Goddard J, Webb DJ. Chronic selective endothelin a receptor antagonism reduces serum uric acid in hypertensive chronic kidney disease. Hypertension 2011;58(2):e11-2.
-
(2011)
Hypertension
, vol.58
, Issue.2
-
-
Dhaun, N.1
Johnston, N.R.2
Goddard, J.3
Webb, D.J.4
-
44
-
-
65949118897
-
Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia
-
Faoro V, Boldingh S, Moreels M, Martinez S, Lamotte M, Unger P, et al.Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia. Chest 2009;135(5):1215-22.
-
(2009)
Chest
, vol.135
, Issue.5
, pp. 1215-1222
-
-
Faoro, V.1
Boldingh, S.2
Moreels, M.3
Martinez, S.4
Lamotte, M.5
Unger, P.6
-
45
-
-
85048476535
-
Bosentan improves exercise capacity in acute hypoxic subjects
-
Faoro V, Huez S, Boldingh S, Moreels M, Martinez S, Bastin R, et al.Bosentan improves exercise capacity in acute hypoxic subjects. Acta Cardiologica 2009;64(4):112.
-
(2009)
Acta Cardiologica
, vol.64
, Issue.4
, pp. 112
-
-
Faoro, V.1
Huez, S.2
Boldingh, S.3
Moreels, M.4
Martinez, S.5
Bastin, R.6
-
46
-
-
47549110195
-
Single-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521: An ascending-dose study in healthy male volunteers
-
Frey R, Muck W, Unger S, Artmeier-Brandt U, Weimann G, Wensing G. Single-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521: An ascending-dose study in healthy male volunteers. Journal of Clinical Pharmacology 2008;48(8):926-34.
-
(2008)
Journal of Clinical Pharmacology
, vol.48
, Issue.8
, pp. 926-934
-
-
Frey, R.1
Muck, W.2
Unger, S.3
Artmeier-Brandt, U.4
Weimann, G.5
Wensing, G.6
-
47
-
-
22844436819
-
Ambrisentan therapy for pulmonary arterial hypertension
-
Galiè N, Badesch D, Oudiz R, Simonneau G, McGoon MD, Keogh AM, et al.Ambrisentan therapy for pulmonary arterial hypertension. Journal of the American College of Cardiology. 2005;46(3):529-35.
-
(2005)
Journal of the American College of Cardiology.
, vol.46
, Issue.3
, pp. 529-535
-
-
Galiè, N.1
Badesch, D.2
Oudiz, R.3
Simonneau, G.4
McGoon, M.D.5
Keogh, A.M.6
-
48
-
-
67649523052
-
Tadalafil therapy for pulmonary arterial hypertension
-
Galiè N, Brundage BH, Ghofrani HA, Oudiz RJ, Simonneau G, Safdar Z, et al.Tadalafil therapy for pulmonary arterial hypertension. Circulation 2009;119(22):2894-903.
-
(2009)
Circulation
, vol.119
, Issue.22
, pp. 2894-2903
-
-
Galiè, N.1
Brundage, B.H.2
Ghofrani, H.A.3
Oudiz, R.J.4
Simonneau, G.5
Safdar, Z.6
-
49
-
-
73449140681
-
3-year survival of patients treated with sitaxentan sodium (Thelin) for pulmonary arterial hypertension
-
Galiè N, Naeije R, Burgess G, Dilleen M. 3-year survival of patients treated with sitaxentan sodium (Thelin) for pulmonary arterial hypertension. European Heart Journal 2009;Abstract Supplement:262.
-
(2009)
European Heart Journal Abstract
, pp. 262
-
-
Galiè, N.1
Naeije, R.2
Burgess, G.3
Dilleen, M.4
-
50
-
-
84944617964
-
Effects of inhaled aviptadil (vasoactive intestinal peptide) in patients with pulmonary arterial hypertension (PAH): Results from a phase II study
-
Conference Publication: Abstract
-
Galiè N, Badesch D, Fleming T, Simonneau G, Rubin L, Ewert R, et al.Effects of inhaled aviptadil (vasoactive intestinal peptide) in patients with pulmonary arterial hypertension (PAH): Results from a phase II study. European Heart Journal 2010;Conference Publication:(Abstract Supplement):22.
-
(2010)
European Heart Journal
, pp. 22
-
-
Galiè, N.1
Badesch, D.2
Fleming, T.3
Simonneau, G.4
Rubin, L.5
Ewert, R.6
-
51
-
-
78349237788
-
Long term use of imatinib In patients with severe pulmonary arterial hypertension [Abstract]
-
Ghofrani HA, Morrell NW, Hoeper MM, Olschewski H, Peacock A, Barst RJ, et al.Long term use of imatinib In patients with severe pulmonary arterial hypertension [Abstract]. American Journal of Respiratory and Critical Care Medicine 2010;181(Meeting Abstracts):A2513.
-
(2010)
American Journal of Respiratory and Critical Care Medicine
, vol.181
, pp. A2513
-
-
Ghofrani, H.A.1
Morrell, N.W.2
Hoeper, M.M.3
Olschewski, H.4
Peacock, A.5
Barst, R.J.6
-
53
-
-
0034720820
-
Acute endothelin A receptor blockade causes selective pulmonary vasodilation in patients with chronic heart failure
-
Givertz MM, Colucci WS, LeJemtel TH, Gottlieb SS, Hare JM, Slawsky MT, et al.Acute endothelin A receptor blockade causes selective pulmonary vasodilation in patients with chronic heart failure. Circulation 2000;101(25):2922-7.
-
(2000)
Circulation
, vol.101
, Issue.25
, pp. 2922-2927
-
-
Givertz, M.M.1
Colucci, W.S.2
LeJemtel, T.H.3
Gottlieb, S.S.4
Hare, J.M.5
Slawsky, M.T.6
-
54
-
-
85103087713
-
Efficacy and safety of sildenafil and atorvastatin added to bosentan as therapy for pulmonary arterial hypertension [Abstract]
-
May 20-25; San Diego, California. [A57] [Poster: K18]
-
Gomberg-Maitland M, McLaughlin V, Gulati M, Rich S, Arbor A. Efficacy and safety of sildenafil and atorvastatin added to bosentan as therapy for pulmonary arterial hypertension [Abstract]. American Thoracic Society 2005 International Conference; May 20-25; San Diego, California. 2005:[A57] [Poster: K18].
-
(2005)
American Thoracic Society 2005 International Conference
-
-
Gomberg-Maitland, M.1
McLaughlin, V.2
Gulati, M.3
Rich, S.4
Arbor, A.5
-
55
-
-
77953795218
-
Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers
-
Gotzkowsky SK, Dingemanse J, Lai A, Mottola D, Laliberte K. Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers. Journal of Clinical Pharmacology 2010;50(7):829-34.
-
(2010)
Journal of Clinical Pharmacology
, vol.50
, Issue.7
, pp. 829-834
-
-
Gotzkowsky, S.K.1
Dingemanse, J.2
Lai, A.3
Mottola, D.4
Laliberte, K.5
-
56
-
-
33847368988
-
Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension
-
Hoeper MM, Leuchte H, Halank M, Wilkens H, Meyer FJ, Seyfarth HJ, et al.Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. The European Respiratory Journal 2006;28(4):691-4.
-
(2006)
The European Respiratory Journal
, vol.28
, Issue.4
, pp. 691-694
-
-
Hoeper, M.M.1
Leuchte, H.2
Halank, M.3
Wilkens, H.4
Meyer, F.J.5
Seyfarth, H.J.6
-
57
-
-
85048496260
-
Role of pulmonary hypertension and right ventricular dysfunction in aerobic exercise capacity limitation in normal volunteers at high altitude
-
Huez S, Faoro V, Moreels M, Bastin R, Retailleau K, Lamotte M, et al.Role of pulmonary hypertension and right ventricular dysfunction in aerobic exercise capacity limitation in normal volunteers at high altitude. Acta Cardiologica 2009;64(1):114.
-
(2009)
Acta Cardiologica
, vol.64
, Issue.1
, pp. 114
-
-
Huez, S.1
Faoro, V.2
Moreels, M.3
Bastin, R.4
Retailleau, K.5
Lamotte, M.6
-
58
-
-
77952019637
-
Combination therapy with bosentan and sildenafil in Eisenmenger syndrome: A randomized, placebo-controlled, double-blinded trial
-
Iversen K, Jensen AS, Jensen TV, Vejlstrup NG, Sondergaard L. Combination therapy with bosentan and sildenafil in Eisenmenger syndrome: A randomized, placebo-controlled, double-blinded trial. European Heart Journal 2010;31(9):1124-31.
-
(2010)
European Heart Journal
, vol.31
, Issue.9
, pp. 1124-1131
-
-
Iversen, K.1
Jensen, A.S.2
Jensen, T.V.3
Vejlstrup, N.G.4
Sondergaard, L.5
-
59
-
-
57449103127
-
Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial
-
Jais X, D'Armini AM, Jansa P, Torbicki A, Delcroix M, Ghofrani HA, et al.Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial. Journal of the American College of Cardiology 2008;52(25):2127-34.
-
(2008)
Journal of the American College of Cardiology
, vol.52
, Issue.25
, pp. 2127-2134
-
-
Jais, X.1
D'Armini, A.M.2
Jansa, P.3
Torbicki, A.4
Delcroix, M.5
Ghofrani, H.A.6
-
60
-
-
0036774973
-
Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?
-
Kalra PR, Moon JC, Coats AJ. Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?. International Journal of Cardiology 2002;85(2-3):195-7.
-
(2002)
International Journal of Cardiology
, vol.85
, Issue.2-3
, pp. 195-197
-
-
Kalra, P.R.1
Moon, J.C.2
Coats, A.J.3
-
61
-
-
40149087049
-
Clinical and hemodynamic effects of bosentan dose optimization in symptomatic heart failure patients with severe systolic dysfunction, associated with secondary pulmonary hypertension-a multi-center randomized study
-
Kaluski E, Cotter G, Leitman M, Milo-Cotter O, Krakover R, Kobrin I, et al.Clinical and hemodynamic effects of bosentan dose optimization in symptomatic heart failure patients with severe systolic dysfunction, associated with secondary pulmonary hypertension-a multi-center randomized study. Cardiology 2008;109(4):273-80.
-
(2008)
Cardiology
, vol.109
, Issue.4
, pp. 273-280
-
-
Kaluski, E.1
Cotter, G.2
Leitman, M.3
Milo-Cotter, O.4
Krakover, R.5
Kobrin, I.6
-
62
-
-
40149087049
-
Clinical and hemodynamic effects of bosentan dose optimization in symptomatic heart failure patients with severe systolic dysfunction, associated with secondary pulmonary hypertension--a multi-center randomized study
-
Kaluski E, Cotter G, Leitman M, Milo-Cotter O, Krakover R, Kobrin I, et al.Clinical and hemodynamic effects of bosentan dose optimization in symptomatic heart failure patients with severe systolic dysfunction, associated with secondary pulmonary hypertension--a multi-center randomized study. Cardiology 2008;109(4):273-80.
-
(2008)
Cardiology
, vol.109
, Issue.4
, pp. 273-280
-
-
Kaluski, E.1
Cotter, G.2
Leitman, M.3
Milo-Cotter, O.4
Krakover, R.5
Kobrin, I.6
-
63
-
-
77950414996
-
A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy
-
Kefford RF, Clingan PR, Brady B, Ballmer A, Morganti A, Hersey P. A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy. Molecular Cancer 2010;9:69.
-
(2010)
Molecular Cancer
, vol.9
, pp. 69
-
-
Kefford, R.F.1
Clingan, P.R.2
Brady, B.3
Ballmer, A.4
Morganti, A.5
Hersey, P.6
-
64
-
-
37849012578
-
BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis
-
King TE, Jr, Behr J, Brown KK, du Bois RM, Lancaster L, de Andrade JA, et al.BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis [King TE Jr Behr J]. American Journal of Respiratory & Critical Care Medicine 2008;177(1):75-81.
-
(2008)
American Journal of Respiratory & Critical Care Medicine
, vol.177
, Issue.1
, pp. 75-81
-
-
King, T.E.1
Behr, J.2
Brown, K.K.3
du Bois, R.M.4
Lancaster, L.5
de Andrade, J.A.6
-
65
-
-
0029087262
-
Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure
-
Kiowski W, Sutsch G, Hunziker P, Muller P, Kim J, Oechslin E, et al.Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure. Lancet 1995;346(8977):732-6.
-
(1995)
Lancet
, vol.346
, Issue.8977
, pp. 732-736
-
-
Kiowski, W.1
Sutsch, G.2
Hunziker, P.3
Muller, P.4
Kim, J.5
Oechslin, E.6
-
66
-
-
10444270963
-
Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist
-
Korn JH, Mayes M, Matucci Cerinic M, Rainisio M, Pope J, Hachulla E, et al.Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis and Rheumatism 2004;50(12):3985-93.
-
(2004)
Arthritis and Rheumatism
, vol.50
, Issue.12
, pp. 3985-3993
-
-
Korn, J.H.1
Mayes, M.2
Matucci Cerinic, M.3
Rainisio, M.4
Pope, J.5
Hachulla, E.6
-
67
-
-
65549089130
-
Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension
-
Lee TM, Chen CC, Shen HN, Chang NC. Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Clinical science 2009;116(6):497-505.
-
(2009)
Clinical science
, vol.116
, Issue.6
, pp. 497-505
-
-
Lee, T.M.1
Chen, C.C.2
Shen, H.N.3
Chang, N.C.4
-
68
-
-
12244251412
-
Efficacy and safety of treprostinil: An epoprostenol analog for primary pulmonary hypertension
-
McLaughlin VV, Gaine SP, Barst RJ, Oudiz RJ, Bourge RC, Frost A, et al.Efficacy and safety of treprostinil: An epoprostenol analog for primary pulmonary hypertension. Journal of Cardiovascular Pharmacology 2003;41(2):293-9.
-
(2003)
Journal of Cardiovascular Pharmacology
, vol.41
, Issue.2
, pp. 293-299
-
-
McLaughlin, V.V.1
Gaine, S.P.2
Barst, R.J.3
Oudiz, R.J.4
Bourge, R.C.5
Frost, A.6
-
69
-
-
33845526777
-
Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension
-
McLaughlin VV, Oudiz RJ, Frost A, Tapson VF, Murali S, Channick RN, et al.Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. American Journal of Respiratory & Critical Care Medicine 2006; Vol. 174, issue 11:1257-63.
-
(2006)
American Journal of Respiratory & Critical Care Medicine
, vol.174
, Issue.11
, pp. 1257-1263
-
-
McLaughlin, V.V.1
Oudiz, R.J.2
Frost, A.3
Tapson, V.F.4
Murali, S.5
Channick, R.N.6
-
70
-
-
77952301237
-
Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial
-
McLaughlin VV, Benza R L, Rubin LJ, Channick RN, Voswinckel R, Tapson VF, et al.Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. Journal of the American College of Cardiology 2010;55(18):1915-22.
-
(2010)
Journal of the American College of Cardiology
, vol.55
, Issue.18
, pp. 1915-1922
-
-
McLaughlin, V.V.1
Benza, R.L.2
Rubin, L.J.3
Channick, R.N.4
Voswinckel, R.5
Tapson, V.F.6
-
71
-
-
33749525364
-
Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension
-
Mereles D, Ehlken N, Kreuscher S, Ghofrani S, Hoeper MM, Halank M, et al.Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation 2006;114(14):1482-9.
-
(2006)
Circulation
, vol.114
, Issue.14
, pp. 1482-1489
-
-
Mereles, D.1
Ehlken, N.2
Kreuscher, S.3
Ghofrani, S.4
Hoeper, M.M.5
Halank, M.6
-
72
-
-
33749028972
-
Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study
-
Modesti PA, Vanni S, Morabito M, Modesti A, Marchetta M, Gamberi T, et al.Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study. Circulation 2006; Vol. 114, issue 13:1410-6.
-
(2006)
Circulation
, vol.114
, Issue.13
, pp. 1410-1416
-
-
Modesti, P.A.1
Vanni, S.2
Morabito, M.3
Modesti, A.4
Marchetta, M.5
Gamberi, T.6
-
73
-
-
78349257100
-
Pulmonary artery pressure limits exercise capacity at high altitude
-
Naeije R, Huez S, Lamotte M, Retailleau K, Neupane S, Abramowicz D, et al.Pulmonary artery pressure limits exercise capacity at high altitude. European Respiratory Journal 2010;36(5):1049-55.
-
(2010)
European Respiratory Journal
, vol.36
, Issue.5
, pp. 1049-1055
-
-
Naeije, R.1
Huez, S.2
Lamotte, M.3
Retailleau, K.4
Neupane, S.5
Abramowicz, D.6
-
74
-
-
79551633577
-
Pharmacokinetics of ambrisentan, a novel drug for treatment of Pulmonary Arterial Hypertension (PAH), in Japanese subjects
-
Nakahara N, Wakamatsu A, Shimamura R, Nohda S, Miki S, Hirama T. Pharmacokinetics of ambrisentan, a novel drug for treatment of Pulmonary Arterial Hypertension (PAH), in Japanese subjects. Japanese Journal of Clinical Pharmacology and Therapeutics 2010;41(6):301-8.
-
(2010)
Japanese Journal of Clinical Pharmacology and Therapeutics
, vol.41
, Issue.6
, pp. 301-308
-
-
Nakahara, N.1
Wakamatsu, A.2
Shimamura, R.3
Nohda, S.4
Miki, S.5
Hirama, T.6
-
75
-
-
44349149660
-
Long-term ambrisentan therapy provides sustained benefit in patients with pulmonary arterial hypertension
-
Oudiz RJ. Long-term ambrisentan therapy provides sustained benefit in patients with pulmonary arterial hypertension. Chest 2007;132(4):474a.
-
(2007)
Chest
, vol.132
, Issue.4
, pp. 474a
-
-
Oudiz, R.J.1
-
76
-
-
70350708667
-
Long-term ambrisentan therapy for the treatment of pulmonary arterial hypertension
-
Oudiz RJ, Galiè N, Olschewski H, Torres F, Frost A, Ghofrani HA, et al.Long-term ambrisentan therapy for the treatment of pulmonary arterial hypertension. Journal of the American College of Cardiology 2009;54(21):1971-81.
-
(2009)
Journal of the American College of Cardiology
, vol.54
, Issue.21
, pp. 1971-1981
-
-
Oudiz, R.J.1
Galiè, N.2
Olschewski, H.3
Torres, F.4
Frost, A.5
Ghofrani, H.A.6
-
77
-
-
85048458371
-
Efficacy and safety of tral bosentan on healing/prevention of digital (finger) ulcers in scleroderma patients
-
Efficacy and safety of tral bosentan on healing/prevention of digital (finger) ulcers in scleroderma patients. http://clinicaltrials.gov/ct2/show/NCT00077584.
-
-
-
-
78
-
-
73149089715
-
Bosentan as a bridge to pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
-
Reesink HJ, Surie S, Kloek JJ, Tan HL, Tepaske R, Fedullo PF, et al.Bosentan as a bridge to pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. Journal of Thoracic & Cardiovascular Surgery 2010;139(1):85-91.
-
(2010)
Journal of Thoracic & Cardiovascular Surgery
, vol.139
, Issue.1
, pp. 85-91
-
-
Reesink, H.J.1
Surie, S.2
Kloek, J.J.3
Tan, H.L.4
Tepaske, R.5
Fedullo, P.F.6
-
79
-
-
33644856615
-
A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension
-
Robbins IM, Kawut SM, Yung D, Reilly MP, Lloyd W, Cunningham G, et al.A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension. European Respiratory Journal 2006;27(3):578-84.
-
(2006)
European Respiratory Journal
, vol.27
, Issue.3
, pp. 578-584
-
-
Robbins, I.M.1
Kawut, S.M.2
Yung, D.3
Reilly, M.P.4
Lloyd, W.5
Cunningham, G.6
-
80
-
-
60449099543
-
Prophylactic bosentan does not improve exercise capacity or lower pulmonary artery systolic pressure at high altitude
-
Seheult RD, Ruh K, Foster GP, Anholm JD. Prophylactic bosentan does not improve exercise capacity or lower pulmonary artery systolic pressure at high altitude. Respiratory Physiology & Neurobiology 2009;165(2-3):123-30.
-
(2009)
Respiratory Physiology & Neurobiology
, vol.165
, Issue.2-3
, pp. 123-130
-
-
Seheult, R.D.1
Ruh, K.2
Foster, G.P.3
Anholm, J.D.4
-
81
-
-
77954222367
-
Randomized, prospective, placebo-controlled trial of bosentan in interstitial lung disease secondary to systemic sclerosis
-
Seibold JR, Denton CP, Furst DE, Guillevin L, Rubin LJ, Wells A, et al.Randomized, prospective, placebo-controlled trial of bosentan in interstitial lung disease secondary to systemic sclerosis. Arthritis and Rheumatism 2010;62(7):2101-8.
-
(2010)
Arthritis and Rheumatism
, vol.62
, Issue.7
, pp. 2101-2108
-
-
Seibold, J.R.1
Denton, C.P.2
Furst, D.E.3
Guillevin, L.4
Rubin, L.J.5
Wells, A.6
-
83
-
-
79551663361
-
Efficacy, safety and tolerability of ACT-293987, a novel oral, non-prostanoid, prostaglandin I2 (IP) receptor agonist: results from a phase IIa study In pulmonary arterial hypertension (PAH)
-
Simonneau G, Lang I, Torbicki A, Hoeper MM, Delcroix M, Karlocai K, et al.Efficacy, safety and tolerability of ACT-293987, a novel oral, non-prostanoid, prostaglandin I2 (IP) receptor agonist: results from a phase IIa study In pulmonary arterial hypertension (PAH). American Journal of Respiratory and Critical Care Medicine 2010;181(Meeting Abstracts):A2515.
-
(2010)
American Journal of Respiratory and Critical Care Medicine
, vol.181
, pp. A2515
-
-
Simonneau, G.1
Lang, I.2
Torbicki, A.3
Hoeper, M.M.4
Delcroix, M.5
Karlocai, K.6
-
84
-
-
57449121379
-
Pharmacokinetics and safety of ambrisentan in combination with sildenafil in healthy volunteers
-
Spence R, Mandagere A, Dufton C, Venitz J. Pharmacokinetics and safety of ambrisentan in combination with sildenafil in healthy volunteers. Journal of Clinical Pharmacology 2008;48(12):1451-9.
-
(2008)
Journal of Clinical Pharmacology
, vol.48
, Issue.12
, pp. 1451-1459
-
-
Spence, R.1
Mandagere, A.2
Dufton, C.3
Venitz, J.4
-
85
-
-
70849086064
-
No clinically relevant pharmacokinetic and safety interactions of ambrisentan in combination with tadalafil in healthy volunteers
-
Spence R, Mandagere A, Harrison B, Dufton C, Boinpally R. No clinically relevant pharmacokinetic and safety interactions of ambrisentan in combination with tadalafil in healthy volunteers. Journal of Pharmaceutical Sciences 2009;98(12):4962-74.
-
(2009)
Journal of Pharmaceutical Sciences
, vol.98
, Issue.12
, pp. 4962-4974
-
-
Spence, R.1
Mandagere, A.2
Harrison, B.3
Dufton, C.4
Boinpally, R.5
-
86
-
-
72949114651
-
The effects of sitaxentan on sildenafil pharmacokinetics and pharmacodynamics in healthy subjects
-
Stavros F, Kramer WG, Wilkins MR. The effects of sitaxentan on sildenafil pharmacokinetics and pharmacodynamics in healthy subjects. British Journal of Clinical Pharmacology 2010;69(1):23-6.
-
(2010)
British Journal of Clinical Pharmacology
, vol.69
, Issue.1
, pp. 23-26
-
-
Stavros, F.1
Kramer, W.G.2
Wilkins, M.R.3
-
87
-
-
58149393089
-
A randomised, controlled trial of bosentan in severe COPD
-
Stolz D, Rasch H, Linka A, Di Valentino M, Meyer A, Brutsche M, et al.A randomised, controlled trial of bosentan in severe COPD. European Respiratory Journal 2008;32(3):619-28.
-
(2008)
European Respiratory Journal
, vol.32
, Issue.3
, pp. 619-628
-
-
Stolz, D.1
Rasch, H.2
Linka, A.3
Di Valentino, M.4
Meyer, A.5
Brutsche, M.6
-
88
-
-
85048483708
-
Safety and feasibility of inhaled iloprost on exercise capacity in patients with pulmonary arterial hypertension
-
Worthington A, Collins N, Haddad R. Safety and feasibility of inhaled iloprost on exercise capacity in patients with pulmonary arterial hypertension. Heart Lung and Circulation 2010;19(2):1.
-
(2010)
Heart Lung and Circulation
, vol.19
, Issue.2
, pp. 1
-
-
Worthington, A.1
Collins, N.2
Haddad, R.3
-
89
-
-
41849103027
-
Pharmacokinetic interaction between tadalafil and bosentan in healthy male subjects
-
Wrishko RE, Dingemanse J, Yu A, Darstein C, Phillips D L, Mitchell MI. Pharmacokinetic interaction between tadalafil and bosentan in healthy male subjects. Journal of Clinical Pharmacology 2008;48(5):610-8.
-
(2008)
Journal of Clinical Pharmacology
, vol.48
, Issue.5
, pp. 610-618
-
-
Wrishko, R.E.1
Dingemanse, J.2
Yu, A.3
Darstein, C.4
Phillips, D.L.5
Mitchell, M.I.6
-
90
-
-
85048469086
-
A randomized open label study comparing bosentan or sildenafil first-line treatment in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH)
-
Palazzini M, Leci E, Bachetti C, Sgro F, Mazzanti G, Beciani E, et al.A randomized open label study comparing bosentan or sildenafil first-line treatment in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). European Heart Journal 2010;31 ( Abstract Supplement ):629-630.
-
(2010)
European Heart Journal
, vol.31
, pp. 629-630
-
-
Palazzini, M.1
Leci, E.2
Bachetti, C.3
Sgro, F.4
Mazzanti, G.5
Beciani, E.6
-
91
-
-
0037464808
-
Statistics Notes: Interaction revisited: the difference between two estimates
-
Altman DG, Bland JM. Statistics Notes: Interaction revisited: the difference between two estimates. BMJ 2003;326(7382):219.
-
(2003)
BMJ
, vol.326
, Issue.7382
, pp. 219
-
-
Altman, D.G.1
Bland, J.M.2
-
92
-
-
77952234421
-
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies
-
Archer SL, Weir EK, Wilkins MR. Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation 2010;121(18):2045-66.
-
(2010)
Circulation
, vol.121
, Issue.18
, pp. 2045-2066
-
-
Archer, S.L.1
Weir, E.K.2
Wilkins, M.R.3
-
93
-
-
17144452827
-
Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial
-
Badesch DB, Tapson VF, McGoon MD, Brundage BH, Rubin LJ, Wigley FM. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial. Annals of Internal Medicine 2000;132(6):425-34.
-
(2000)
Annals of Internal Medicine
, vol.132
, Issue.6
, pp. 425-434
-
-
Badesch, D.B.1
Tapson, V.F.2
McGoon, M.D.3
Brundage, B.H.4
Rubin, L.J.5
Wigley, F.M.6
-
94
-
-
44349164345
-
Ambrisentan therapy for pulmonary arterial hypertension: a comparison by pah etiology
-
Badesch DB, the Aries Study Group. Ambrisentan therapy for pulmonary arterial hypertension: a comparison by pah etiology. Chest 2007;132(4):488-9.
-
(2007)
Chest
, vol.132
, Issue.4
, pp. 488-489
-
-
Badesch, D.B.1
-
95
-
-
0030031888
-
A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group
-
Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. The New England Journal of Medicine 1996;334(5):296-302.
-
(1996)
The New England Journal of Medicine
, vol.334
, Issue.5
, pp. 296-302
-
-
Barst, R.J.1
Rubin, L.J.2
Long, W.A.3
McGoon, M.D.4
Rich, S.5
Badesch, D.B.6
-
96
-
-
85048482152
-
Clinical and cost effectiveness of treatments for pulmonary arterial hypertension (PAH) within their licensed indications [updated 21/02/2008]
-
Chen Y, Jowett S, Barton P, Malottki K, Hyde C, Gibbs S, et al.Clinical and cost effectiveness of treatments for pulmonary arterial hypertension (PAH) within their licensed indications [updated 21/02/2008]. West Midlands Health Technology Assessment Collaboration 2008.
-
(2008)
West Midlands Health Technology Assessment Collaboration
-
-
Chen, Y.1
Jowett, S.2
Barton, P.3
Malottki, K.4
Hyde, C.5
Gibbs, S.6
-
97
-
-
33750344748
-
Bosentan treatment for pulmonary arterial hypertension related to connective tissue disease: a subgroup analysis of the pivotal clinical trials and their open-label extensions
-
Denton CP, Humbert M, Rubin L, Black CM. Bosentan treatment for pulmonary arterial hypertension related to connective tissue disease: a subgroup analysis of the pivotal clinical trials and their open-label extensions. Annals of the Rheumatic Diseases 2006;65(10):1336-40.
-
(2006)
Annals of the Rheumatic Diseases
, vol.65
, Issue.10
, pp. 1336-1340
-
-
Denton, C.P.1
Humbert, M.2
Rubin, L.3
Black, C.M.4
-
98
-
-
0029022496
-
Acute pro-inflammatory actions of endothelin-1 in the guinea-pig lung: involvement of ETA and ETB receptors
-
Filep JG, Fournier A, Foldes-Filep E. Acute pro-inflammatory actions of endothelin-1 in the guinea-pig lung: involvement of ETA and ETB receptors. British Journal of Pharmacology 1995;115(2):227-36.
-
(1995)
British Journal of Pharmacology
, vol.115
, Issue.2
, pp. 227-236
-
-
Filep, J.G.1
Fournier, A.2
Foldes-Filep, E.3
-
99
-
-
0021193273
-
Primary pulmonary hypertension: natural history and importance of thrombosis
-
Fuster V, Steele PM, Edwards ED, Gersh DJ, McGoon MD, Frye RL. Primary pulmonary hypertension: natural history and importance of thrombosis. Circulation 1984;70(4):580-7.
-
(1984)
Circulation
, vol.70
, Issue.4
, pp. 580-587
-
-
Fuster, V.1
Steele, P.M.2
Edwards, E.D.3
Gersh, D.J.4
McGoon, M.D.5
Frye, R.L.6
-
100
-
-
26444534291
-
Sildenafil citrate therapy for pulmonary arterial hypertension
-
Galiè N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D, et al.Sildenafil citrate therapy for pulmonary arterial hypertension. New England Journal of Medicine 2005;353:2148-57.
-
(2005)
New England Journal of Medicine
, vol.353
, pp. 2148-2157
-
-
Galiè, N.1
Ghofrani, H.A.2
Torbicki, A.3
Barst, R.J.4
Rubin, L.J.5
Badesch, D.6
-
101
-
-
70349634397
-
Guidelines for the diagnosis and treatment of pulmonary hypertension
-
Galiè N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA, et al.Guidelines for the diagnosis and treatment of pulmonary hypertension. European Respiratory Journal 2009;34(6):1219-63.
-
(2009)
European Respiratory Journal
, vol.34
, Issue.6
, pp. 1219-1263
-
-
Galiè, N.1
Hoeper, M.M.2
Humbert, M.3
Torbicki, A.4
Vachiery, J.L.5
Barbera, J.A.6
-
102
-
-
0030598620
-
Effects of Ro 47-0203 on endothelin-1 and sarafotoxin S6c-induced contractions of human bronchus and guinea-pig trachea
-
Gater PR, Wasserman MA, Renzetti LM. Effects of Ro 47-0203 on endothelin-1 and sarafotoxin S6c-induced contractions of human bronchus and guinea-pig trachea. European Journal of Pharmacology 1996;304(1-3):123-8.
-
(1996)
European Journal of Pharmacology
, vol.304
, Issue.1-3
, pp. 123-128
-
-
Gater, P.R.1
Wasserman, M.A.2
Renzetti, L.M.3
-
103
-
-
0027324745
-
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
-
Giaid A, Yanagisawa M, Langleben D, Michel RP, Levy R, Shennib H, et al.Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. New England Journal of Medicine 1993;328:1732-9.
-
(1993)
New England Journal of Medicine
, vol.328
, pp. 1732-1739
-
-
Giaid, A.1
Yanagisawa, M.2
Langleben, D.3
Michel, R.P.4
Levy, R.5
Shennib, H.6
-
104
-
-
0034595378
-
Improvement in exercise capacity with nitric oxide inhalation in patients with precapillary pulmonary hypertension
-
Hasuda T, Satoh T, Shimouchi A, Sakamaki F, Kyotani S, Matsumoto T. Improvement in exercise capacity with nitric oxide inhalation in patients with precapillary pulmonary hypertension. Circulation 2000;101(17):2066-70.
-
(2000)
Circulation
, vol.101
, Issue.17
, pp. 2066-2070
-
-
Hasuda, T.1
Satoh, T.2
Shimouchi, A.3
Sakamaki, F.4
Kyotani, S.5
Matsumoto, T.6
-
105
-
-
34547558919
-
Results of European post-marketing surveillance of bosentan in pulmonary hypertension
-
Humbert M, Segal ES, Kiely DG, Carlsen J, Schwierin B, Hoeper MM. Results of European post-marketing surveillance of bosentan in pulmonary hypertension. European Respiratory Journal 2007;30(2):338-44.
-
(2007)
European Respiratory Journal
, vol.30
, Issue.2
, pp. 338-344
-
-
Humbert, M.1
Segal, E.S.2
Kiely, D.G.3
Carlsen, J.4
Schwierin, B.5
Hoeper, M.M.6
-
106
-
-
85047675578
-
Endothelin receptors in cultured adult rat cardiac fibroblasts
-
Katwa LC, Guarda E, Weber KT. Endothelin receptors in cultured adult rat cardiac fibroblasts. Cardiovascular Research 1993;27:2125-9.
-
(1993)
Cardiovascular Research
, vol.27
, pp. 2125-2129
-
-
Katwa, L.C.1
Guarda, E.2
Weber, K.T.3
-
107
-
-
0033917343
-
Pulmonary vascular remodeling distal to pulmonary artery ligation is accompanied by upregulation of endothelin receptors and nitric oxide synthase
-
Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, et al.Pulmonary vascular remodeling distal to pulmonary artery ligation is accompanied by upregulation of endothelin receptors and nitric oxide synthase. Experimental Lung Research 2000;26(4):287-301.
-
(2000)
Experimental Lung Research
, vol.26
, Issue.4
, pp. 287-301
-
-
Kim, H.1
Yung, G.L.2
Marsh, J.J.3
Konopka, R.G.4
Pedersen, C.A.5
Chiles, P.G.6
-
108
-
-
33645847524
-
Treatments for pulmonary arterial hypertension
-
Liu C, Liu K, Ji Z, Liu G. Treatments for pulmonary arterial hypertension. Respiratory Medicine 2006;100(5):765-74.
-
(2006)
Respiratory Medicine
, vol.100
, Issue.5
, pp. 765-774
-
-
Liu, C.1
Liu, K.2
Ji, Z.3
Liu, G.4
-
109
-
-
0028839144
-
Endothelin induced collagen remodeling in experimental pulmonary hypertension
-
Mansoor AM, Honda M, Saida K, Ishinaga Y, Kuramochi T, Maeda A, et al.Endothelin induced collagen remodeling in experimental pulmonary hypertension. Biochemical and Biophysical Research Communications 1995;215(3):981-6.
-
(1995)
Biochemical and Biophysical Research Communications
, vol.215
, Issue.3
, pp. 981-986
-
-
Mansoor, A.M.1
Honda, M.2
Saida, K.3
Ishinaga, Y.4
Kuramochi, T.5
Maeda, A.6
-
110
-
-
13844280943
-
Survival with first-line bosentan in patients with primary pulmonary hypertension
-
McLaughlin VV, Sitbon O, Badesch DB, Barst RJ, Black C, Galiè N, et al.Survival with first-line bosentan in patients with primary pulmonary hypertension. European Respiratory Journal 2005;25(2):244-9.
-
(2005)
European Respiratory Journal
, vol.25
, Issue.2
, pp. 244-249
-
-
McLaughlin, V.V.1
Sitbon, O.2
Badesch, D.B.3
Barst, R.J.4
Black, C.5
Galiè, N.6
-
111
-
-
0034107636
-
Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing
-
Miyamoto S, Nagaya N, Satoh T, Kyotani S, Sakamaki F, Fujita M, et al.Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing. American Journal of Respiratory and Critical Care Medicine 2000;161:487-92.
-
(2000)
American Journal of Respiratory and Critical Care Medicine
, vol.161
, pp. 487-492
-
-
Miyamoto, S.1
Nagaya, N.2
Satoh, T.3
Kyotani, S.4
Sakamaki, F.5
Fujita, M.6
-
112
-
-
84911491685
-
Types of Pulmonary Hypertension
-
accessed 15/11/2011
-
Types of Pulmonary Hypertension. website: http://www.nhlbi.nih.gov/health/health-topics/topics/pah/types.html accessed 15/11/2011.
-
-
-
-
115
-
-
0026632785
-
The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension
-
Rich S, Kaufmann E, Levy PS. The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. The New England Journal of Medicine 1992;327(2):76-81.
-
(1992)
The New England Journal of Medicine
, vol.327
, Issue.2
, pp. 76-81
-
-
Rich, S.1
Kaufmann, E.2
Levy, P.S.3
-
116
-
-
0035171979
-
Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension
-
Rubens C, Ewert R, Halank M, Wensel R, Orzechowski HD, Schultheiss HP. Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension. Chest 2001;120(5):1562-9.
-
(2001)
Chest
, vol.120
, Issue.5
, pp. 1562-1569
-
-
Rubens, C.1
Ewert, R.2
Halank, M.3
Wensel, R.4
Orzechowski, H.D.5
Schultheiss, H.P.6
-
117
-
-
33745309657
-
Sitaxsentan, a selective endothelin-a receptor antagonist, improves exercise capacity in pulmonary arterial hypertension (PAH) associated with connective tissue disease (CTD)
-
Seibold J, Badesch D, Galiè N, Langleben D, Naeije R, Simonneau G, et al.Sitaxsentan, a selective endothelin-a receptor antagonist, improves exercise capacity in pulmonary arterial hypertension (PAH) associated with connective tissue disease (CTD). Chest 2005; Vol. 128, issue 4:219S.
-
(2005)
Chest
, vol.128
, Issue.4
, pp. 219S
-
-
Seibold, J.1
Badesch, D.2
Galiè, N.3
Langleben, D.4
Naeije, R.5
Simonneau, G.6
-
118
-
-
0031869664
-
Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension
-
Sitbon O, Humbert M, Jagot JL, Taravella O, Fartoukh M, Parent F, et al.Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension. The European Respiratory Journal 1998;12:265-70.
-
(1998)
The European Respiratory Journal
, vol.12
, pp. 265-270
-
-
Sitbon, O.1
Humbert, M.2
Jagot, J.L.3
Taravella, O.4
Fartoukh, M.5
Parent, F.6
-
119
-
-
0037151645
-
Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival
-
Sitbon O, Humbert M, Nunes H, Parent F, Garcia G, Herve P, et al.Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. Journal of the American College of Cardiology 2002;40(4):780-8.
-
(2002)
Journal of the American College of Cardiology
, vol.40
, Issue.4
, pp. 780-788
-
-
Sitbon, O.1
Humbert, M.2
Nunes, H.3
Parent, F.4
Garcia, G.5
Herve, P.6
-
120
-
-
0034914829
-
Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: relevance to pathogenesis of pulmonary hypertension and vascular remodeling
-
Wort SJ, Woods M, Warner TD, Evans TW, Mitchell JA. Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: relevance to pathogenesis of pulmonary hypertension and vascular remodeling. American Journal of Respiratory Cell and Molecular Biology 2001;25:104-10.
-
(2001)
American Journal of Respiratory Cell and Molecular Biology
, vol.25
, pp. 104-110
-
-
Wort, S.J.1
Woods, M.2
Warner, T.D.3
Evans, T.W.4
Mitchell, J.A.5
-
121
-
-
84875513420
-
Endothelin receptor antagonists for pulmonary arterial hypertension
-
Liu C, Chen J. Endothelin receptor antagonists for pulmonary arterial hypertension. Cochrane Database of Systematic Reviews 2004, Issue 4. [DOI: 10.1002/14651858.CD004434.pub2]
-
(2004)
Cochrane Database of Systematic Reviews
, Issue.4
-
-
Liu, C.1
Chen, J.2
-
122
-
-
84875513420
-
Endothelin receptor antagonists for pulmonary arterial hypertension
-
Liu C, Chen J. Endothelin receptor antagonists for pulmonary arterial hypertension. Cochrane Database of Systematic Reviews 2006, Issue 3. [DOI: 10.1002/14651858.CD004434.pub3]
-
(2006)
Cochrane Database of Systematic Reviews
, Issue.3
-
-
Liu, C.1
Chen, J.2
-
123
-
-
70049091002
-
Endothelin receptor antagonists for pulmonary arterial hypertension
-
Liu C, Chen J, Gao Y, Deng B, Liu K. Endothelin receptor antagonists for pulmonary arterial hypertension. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD004434.pub4]
-
(2009)
Cochrane Database of Systematic Reviews
, Issue.3
-
-
Liu, C.1
Chen, J.2
Gao, Y.3
Deng, B.4
Liu, K.5
|