Cellular polyamines promote amyloid-Beta (Aβ) peptide fibrillation and modulate the aggregation pathways

ACS Chemical Neuroscience

Volumn 4, Issue 3, 2013, Pages 454-462

  Luo, Jinghui ^a   Yu, Chien Hung ^a   Yu, Huixin ^b   Borstnar, Rok ^c,d   Kamerlin, Shina C L ^c   Gräslund, Astrid ^e   Abrahams, Jan Pieter ^a   Wärmländer, Sebastian K T S ^e  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UPPSALA UNIVERSITY   (Sweden)

^d NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Alzheimer's disease; amyloid beta peptide; natural polyamines; peptide fibrillation; protein aggregation pathway; protein ligand binding

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN[1-40]; PUTRESCINE; SPERMIDINE; SPERMINE; THIOFLAVINE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); FLUORESCENCE SPECTROSCOPY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; SPECTROSCOPY;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PEPTIDES; HUMANS; PEPTIDE FRAGMENTS; POLYAMINES; PUTRESCINE; SIGNAL TRANSDUCTION; SPERMIDINE; SPERMINE;

EID: 84875502892     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn300170x     Document Type: Article

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