Hepatoprotective effects of S-adenosylmethionine and silybin on canine hepatocytes in vitro

Journal of Animal Physiology and Animal Nutrition

Volumn 97, Issue 2, 2013, Pages 331-341

  Au, A Y ^a,b   Hasenwinkel, J M ^b   Frondoza, C G ^a,c,d  

^a NUTRAMAX LABORATORIES INC   (United States)

^b Syracuse University   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Collagen; Hepatocytes; Inflammation; Nuclear factor kappa B; Oxidative stress

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BIOLOGICAL MARKER; GLUTATHIONE; INTERLEUKIN 1BETA; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PROSTAGLANDIN E2; S ADENOSYLMETHIONINE; SILIBININ; SILYMARIN;

ANIMAL; ARTICLE; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DOG; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LIVER CELL; METABOLISM; OXIDATIVE STRESS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BIOLOGICAL MARKERS; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CCL2; DINOPROSTONE; DOGS; GENE EXPRESSION REGULATION; GLUTATHIONE; HEPATOCYTES; INTERLEUKIN-1BETA; INTERLEUKIN-8; OXIDATIVE STRESS; S-ADENOSYLMETHIONINE; SILYMARIN;

EID: 84875500672     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2012.01275.x     Document Type: Article

References (47)

1. Au, A. Y.; Hasenwinkel, J. M.; Frondoza, C. F., 2011: Silybin inhibits interleukin-1β-induced production of pro-inflammatory mediators in canine hepatocyte cultures. Journal of Veterinary Pharmacology and Therapeutics34, 120-129.
2. Bellas, R. E.; FitzGerald, M. J.; Fausto, N.; Sonenshein, G. E., 1997: Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes. American Journal of Pathology151, 891-896.
3. Cederbaum, A., 2009: Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert Opinion on Drug Metabolism and Toxicology5, 1223-1244.
4. Cederbaum, A. I., 2010: Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury. World Journal of Gastroenterology16, 1366-1376.
5. Center, S. A.; Randolph, J. F.; Warner, K. L.; McCabe-McClelland, J.; Foureman, P.; Hoffmann, W. E.; Erb, H. N., 2005: The effects of S-adenosylmethionine on clinical pathology and redox potential in the red blood cell, liver, and bile of clinically normal cats. Journal of Veterinary Internal Medicine19, 303-314.
6. Chaisson, M. L.; Brooling, J. T.; Ladiges, W.; Tsai, S.; Fausto, N., 2002: Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy. The Journal of Clinical Investigation110, 193-202.
7. Chia, A. J.; Goldring, C. E.; Kitteringham, N. R.; Wong, S. Q.; Morgan, P.; Park, B. K., 2010: Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB. Biochemical Pharmacology80, 410-421.
8. Comelli, M. C.; Mengs, U.; Schneider, C.; Prosdocimi, M., 2007: Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy. Integrative Cancer Therapies6, 120-129.
9. Copple, I. M.; Goldring, C. E.; Kitteringham, N. R.; Park, B. K., 2008: The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity. Toxicology, 246, 24-33.
10. Dasarathy, S., 2008: Inflammation and liver. Journal of Parenteral and Enteral Nutrition, 32, 660-666.
11. Erickson, A. M.; Nevarea, Z.; Gipp, J. J.; Mulcahy, R. T., 2002: Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene. Revision of the ARE consensus sequence. Journal of Biological Chemistry277, 30730-30737.
12. Ferre, N.; Claria, J., 2006: New insights into the regulation of liver inflammation and oxidative stress. Mini Reviews in Medicinal Chemistry6, 1321-1330.
13. Filburn, C. R.; Kettenacker, R.; Griffin, D. W., 2007: Bioavailability of a silybin-phosphatidylcholine complex in dogs. Journal of Veterinary Pharmacology Therapeutics30, 132-138.
14. Garcia-Roman, R.; Salazar-Gonzalez, D.; Rosas, S.; Arellanes-Robledo, J.; Beltran-Ramirez, O.; Fattel-Fazenda, S.; Villa-Trevino, S., 2008: The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis. Free Radical Research42, 331-343.
15. Girish, C.; Koner, B. C.; Jayanthi, S.; Ramachandra Rao, K.; Rajesh, B.; Pradhan, S. C., 2009: Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundamental and Clinical Pharmacology23, 735-745.
16. Griffin, D.; Whalen, M.; Filburn, C. 2009: Bioavailability of a novel formulation of S-adenosylmethionine in beagle dogs. In: ACVIM Montreal, Quebec. (ed.), Proceedings of the ACVIM Forum and Canadian Veterinary Medical Association Convention. Lakewood, CO. Vol. 2009, 792.
17. ® for the prevention of lomustine (CCNU) induced hepatotoxicity in tumor bearing dogs: interim analysis. In: ACVIM Montreal, Quebec. (ed.), Proceedings of the ACVIM Forum and Canadian Veterinary Medical Association Convention. Lakewood, CO. Vol. 2009, 760.
18. Jaiswal, A. K., 2004: Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radical Biology and Medicine36, 1199-1207.
19. Kaneshiro, Y.; Nakano, H.; Kumada, K.; Boudjema, K.; Kitamura, N.; Shimura, H.; Barama, A.; Kigawa, G.; Tatsuno, M.; Fujiwara, Y.; Baek, Y.; Sasaki, J.; Nagasaki, H.; Yamaguchi, M., 1998: Augmentation of mitochondrial reduced glutathione by S-adenosyl-L-methionine administration in ischemia-reperfusion injury of the rat steatotic liver induced by choline-methionine-deficient diet. European Surgical Research, 30, 34-42.
20. Kaplowitz, N., 2000: Mechanisms of liver cell injury. Journal of Hepatology, 32, 39-47.
21. Kaplowitz, N., 2002: Biochemical and cellular mechanisms of toxic liver injury. Seminars in Liver Disease22, 137-144.
22. Kidd, P.; Head, K., 2005: A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Alternative Medicine Review10, 193-203.
23. Klaassen, C. D.; Reisman, S. A., 2010: Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicology and Applied Pharmacology244, 57-65.
24. Lee, J. M.; Johnson, J. A., 2004: An important role of Nrf2-ARE pathway in the cellular defense mechanism. Journal of Biochemistry and Molecular Biology37, 139-143.
25. Lee, J. M.; Li, J.; Johnson, D. A.; Stein, T. D.; Kraft, A. D.; Calkins, M. J.; Jakel, R. J.; Johnson, J. A., 2005: Nrf2, a multi-organ protector?The FASEB Journal19, 1061-1066.
26. Lieber, C. S., 2002: S-adenosyl-L-methionine: its role in the treatment of liver disorders. American Journal of Clinical Nutrition, 76, 1183S-1187S.
27. Llacuna, L.; Mari, M.; Lluis, J. M.; Garcia-Ruiz, C.; Fernandez-Checa, J. C.; Morales, A., 2009: Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion. American Journal of Pathology174, 1776-1785.
28. Lu, S. C.; Mato, J. M., 2008: S-Adenosylmethionine in cell growth, apoptosis and liver cancer. Journal of Gastroenterology and Hepatology23, S73-S77.
29. Marra, F., 2002: Chemokines in liver inflammation and fibrosis. Frontiers in Bioscience7, d1899-d1914.
30. Ming, Z.; Fan, Y. J.; Yang, X.; Lautt, W. W., 2006: Synergistic protection by S-adenosylmethionine with vitamins C and E on liver injury induced by thioacetamide in rats. Free Radical Biology and Medicine40, 617-624.
31. Muriel, P., 2009: NF-kappaB in liver diseases: a target for drug therapy. Journal of Applied Toxicology, 29, 91-100.
32. Muriel, P.; Rivera-Espinoza, Y., 2008: Beneficial drugs for liver diseases. Journal of Applied Toxicology28, 93-103.
33. Oz, H. S.; Im, H. J.; Chen, T. S.; de Villiers, W. J.; McClain, C. J., 2006: Glutathione-enhancing agents protect against steatohepatitis in a dietary model. Journal of Biochemical and Molecular Toxicology20, 39-47.
34. Parola, M.; Robino, G., 2001: Oxidative stress-related molecules and liver fibrosis. Journal of Hepatology35, 297-306.
35. Polyak, S. J.; Morishima, C.; Lohmann, V.; Pal, S.; Lee, D. Y.; Liu, Y.; Graf, T. N.; Oberlies, N. H., 2010: Identification of hepatoprotective flavonolignans from silymarin. Proceedings of the National Academy of Sciences of the United States of America107, 5995-5999.
36. Pradhan, S. C.; Girish, C., 2006: Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian Journal of Medical Research124, 491-504.
37. Prieto-Sagredo, J.; Ricalde-Recchia, I.; Duran-Lizarraga, M. E.; Gonsebatt, M. E.; Fanjul-Moles, M. L., 2000: Changes in hemolymph glutathione status after variation in photoperiod and light-irradiance in crayfish Procambarus clarkii and Procambarus digueti. Photochemistry and Photobiology71, 487-492.
38. Saller, R.; Meier, R.; Brignoli, R., 2001: The use of silymarin in the treatment of liver diseases. Drugs61, 2035-2063.
39. Schoemaker, M. H.; Moshage, H., 2004: Defying death: the hepatocyte's survival kit. Clinical Science (London)107, 13-25. (Review).
40. Schwabe, R. F.; Brenner, D. A., 2007: Nuclear factor-kappaB in the liver: friend or foe?Gastroenterology132, 2601-2604.
41. Surh, Y. J.; Kundu, J. K.; Na, H. K., 2008: Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Medica74, 1526-1539.
42. Thong-Ngam, D.; Samuhasaneeto, S.; Kulaputana, O.; Klaikeaw, N., 2007: N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis. World Journal of Gastroenterology13, 5127-5132.
43. Ursini, F.; Maiorino, M.; Brigelius-Flohe, R.; Aumann, K. D.; Roveri, A.; Schomburg, D.; Flohe, L., 1995: Diversity of glutathione peroxidases. Methods in Enzymology252, 38-53.
44. Webb, C. B.; Twedt, D. C.; Fettman, M. J.; Mason, G., 2003: S-adenosylmethionine (SAMe) in a feline acetaminophen model of oxidative injury. Journal of Feline Medicine and Surgery5, 69-75.
45. Webster, C. R.; Boria, P.; Usechak, P.; Anwer, M. S., 2002: S-adenosylmethionine and cAMP confer differential cytoprotection against bile acid-induced apoptosis in canine renal tubular cells and primary rat hepatocytes. Veterinary Therapeutics3, 474-484.
46. Yang, J.; He, Y.; Du, Y. X.; Tang, L. L.; Wang, G. J.; Fawcett, J. P., 2009: Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers. Clinical Therapeutics31, 311-320.
47. Yang, H.; Ko, K.; Xia, M.; Li, T. W.; Oh, P.; Li, J.; Lu, S. C., 2010: Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice. Hepatology51, 1291-1301.