S-adenosyl-L-methionine: Its role in the treatment of liver disorders

American Journal of Clinical Nutrition

Volumn 76, Issue 5, 2002, Pages

  Lieber, Charles S ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcoholic liver injury; Baboons; Cholestasis; Fibrosis; Liver disorders; Mitochondria; Oxidative stress; S Adenosyl L methionine; SAMe

Indexed keywords

ACETALDEHYDE; ALCOHOL; CYSTEINE; CYTOCHROME P450 2E1; GLUTATHIONE; OXYGEN RADICAL; S ADENOSYLMETHIONINE;

ALCOHOL LIVER DISEASE; ARTICLE; BABOON; BIOACCUMULATION; DEFENSE MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; LIVER DISEASE; LIVER MITOCHONDRION; NONHUMAN; NUTRIENT; OXIDATIVE STRESS; RAT;

PAPIO; PAPIO HAMADRYAS;

EID: 0036829222     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/76.5.1183s     Document Type: Article

References (50)

1. Lieber CS, Packer L. S-Adenosyl-L-methionine: Molecular, biological, and clinical aspects - An introduction. Am J Clin Nutr 2002; 76(suppl):1148S-50S.
2. Lieber CS. Ademethionine and alcohol. In: Lieber CS, ed. S-Adenosylmethionine in the treatment of liver disease. Milan, Italy: UTET, 2001:45-60.
3. Finkelstein JD, Martin JJ. Methionine metabolism in mammals. J Biol Chem 1986;261:1582-7.
4. Duce AM, Ortiz P, Cabrero C, Mato JM. S-Adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 1988;8:65-8.
5. Iber FL, Rosen H, Stanley MA, Levenson SM, Chalmers TC. The plasma amino acids in patients with liver failure. J Lab Clin Med 1957;50:417-25.
6. Fischer JE, Yoshimura N, Aguirre A, et al. Plasma amino acids in patients with hepatic encephalopathy. Effects of amino acids infusions. Am J Surg 1974;127:40-7.
7. Montanari A, Simoni I, Vallisa D, et al. Free amino acids in plasma and skeletal muscle of patients with liver cirrhosis. Hepatology 1988; 8:1034-9.
8. Hardwick DF, Applegarth DA, Cockcroft DM, Ross PM, Cder RJ. Pathogenesis of methionine-induced toxicity. Metabolism 1970;19: 381-91.
9. Berdanier CD. Handbook of Nutrition and Food. Boca Raton, FL: CRC Press, 2002:225.
10. Lieber CS. Role of S-Adenosyl-L-methionine in the treatment of liver disease. J Hepatol 1999;30:1155-9.
11. Lieber CS. Alcohol and oxidative stress. In: Sen CK, ed. Handbook of Oxidants and Antioxidants in Exercise. 2nd Ed. Amsterdam: Elsevier Science BV, 2000:951-75.
12. Orrenius S, Jones DP. Functions of glutathione in drug metabolism. In: Sies H, Wendell A, eds. Functions of Glutathione in Liver and Kidney. Berlin: Springer-Verlag, 1978:164-75.
13. Giudici GA, Le Grazie C, Di Padova C. The use of ademethionine (SAMe) in the treatment of cholestatic liver disorders: Meta-analysis of clinical trials. In: Mato JM, Lieber C, Kaplowitz N, Caballero A, eds. Methionine Metabolism: Molecular Mechanism and Clinical Implications. Madrid: CSIC Press, 1992:67-79.
14. Frezza M, Surrenti C, Manzillo G, Fiaccadori F, Bortilini M, Di Padova C. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis: A double-blind placebo controlled study. Gastroenterology 1990;99:211-5.
15. Frezza M, Pozzato G, Chiesa L, Stramentinoli G, Di Padova C. Reversal of intrahepatic cholestasis of pregnancy in women after high dose S-adenosyl-L-methionine administration. Hepatology 1984; 4:274-8.
16. Belli DC, Fournier LA, Lepage G, Yousef I, Roy CC. S-adenosyl-L-methionine prevents total parenteral nutrition-induced cholestasis in the rat. J Hepatol 1994;21:18-23.
17. Caballeria J, Rodes J. Ademetionine and liver fibrosis. In: Lieber CS, ed. S-Adenosylmethionine in the Treatment of Liver Disease. Milan, Italy: UTET, 2001:85-98.
18. Martínez-Chantar ML, García-Trevijano ER, Latasa MU, et al. Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury. Am J Clin Nutr 2002;76(suppl): 1177S-82S.
19. Lieber CS. Medical and Nutritional Complications of Alcoholism: Mechanisms and Management. New York: Plenum Press, 1992.
20. Lieber CS. Hepatic, metabolic, and nutritional disorders of alcoholism: From pathogenesis to therapy. Crit Rev Clin Lab Sci 2000; 37:551-84.
21. Seitz HK, Lieber CS, Simanowski UA. Textbook of Organ Damage Produced by Alcohol and Alcoholism. Heidelberg, Germany: Johann Ambrosius Barth, 1995.
22. Lieber CS. Effect of S-adenosyl-L-methionine (SAMe) and other natural compounds in alcoholic and nonalcoholic liver injury. Prog Hepato-Pharmacol 1997;11:81-92.
23. Lieber CS, DeCarli LM. An experimental model of alcohol feeding and liver injury in the baboon. J Med Primatol 1974;3: 153-63.
24. Lieber CS, Leo MA, Mak KM, DeCarli LM, Sato S. Choline fails to prevent liver fibrosis in ethanol-fed baboons but causes toxicity. Hepatology 1985;5:561-72.
25. lob V, Coon WW, Slona M. Free amino acids in liver, plasma and muscle of patients with cirrhosis of the liver. J Surg Res 1967;7:41-3.
26. Kinsell L, Harper HA, Barton HC, Michaels GD, Weiss HA. Rate of disappearance from plasma of intravenously administrated methionine in patients with liver damage. Science 1947;106: 589-94.
27. Horowitz JH, Rypins EB, Henderson JM, et al. Evidence for impairment of transsulfuration pathway in cirrhosis. Gastroenterology 1981; 81:668-75.
28. Lieber CS, Casini A, DeCarli LM, et al. S-Adenosyl-L-methionine attenuates alcohol induced liver injury in the baboon. Hepatology 1990;11:165-72.
29. Lieber CS. Cytochrome P4502E1: Its physiological and pathological role. Physiol Rev 1997;77:517-44.
30. Lieber CS. Microsomal ethanol-oxidizing system (MEOS), the first 30 years (1968-1998) - A review. Alcohol Clin Exp Res 1999;23: 991-1007.
31. Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber CS. The intralobular distribution of ethanolinducible P450IIE1 in rat and human liver. Hepatology 1989;10:437-46.
32. Lieber CS. Alcoholic liver disease: New insights in pathogenesis lead to new treatments. J Hepatol 2000;32:113-28.
33. Speisky H, MacDonald A, Giles G, Orrego H, Israel Y. Increased loss of decreased synthesis of hepatic glutathione after acute ethanol administration. Biochem J 1985;225:565-72.
34. Morton S, Mitchell MC. Effects of chronic ethanol feeding on glutathione turnover in the rat. Biochem Pharmacol 1985;34: 1559-63.
35. Shaw S, Lieber CS, Plasma amino acid abnormalities in the alcoholic: Respective role of alcohol, nutrition and liver injury. Gastroenterology 1978;74:677-82.
36. Israel Y, Speisky H, Lanca AJ, Iwamura S, Hirai M, Varghese G. Metabolism of hepatic glutathione and its relevance in alcohol induced liver damage. Cell Mol Aspects Cirrhosis 1992;216:25-37.
37. Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, FemandezCheca JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 1992;6: 1423-7.
38. Leo MA, Rosman A, Lieber CS. Differential depletion of carotenoids and tocopherol in liver diseases. Hepatology 1993;17:977-86.
39. Dicker E, Cederbaum AI. Increased oxygen radical-dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption. FASEB J 1988;2:2901-6.
40. Vendemiale G, Altomare E, Trizio T, et al. Effect of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol 1989;24:407-15.
41. Loguercio C, Nardi G, Argenzio F, et al. Effect of S-adenosyl-L-methionine administration on red blood cell cysteine and glutathione levels in alcoholic patients with and without liver disease. Alcohol Alcohol 1994;29:597-604.
42. Colell A, Garcia-Ruiz C, Morales A, et al. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: Effect of membrane physical properties and S-adenosyl-L-methionine. Hepatology 1997;26:699-708.
43. Hasumura Y, Teschke R, Lieber CS. Hepatic microsomal ethanol oxidizing system (MEOS): Dissociation from reduced nicotinamide adenine dinucleotide phosphateoxidase and possible role of form 1 of cytochrome P450. J Pharmacol Exp Ther 1975;194:469-74.
44. Lieber CS, Baraona E, HernandezMunoz R, et al. Impaired oxygen utilization: A new mechanism for the hepatotoxicity of ethanol in subhuman primates. J Clin Invest 1989;83:1682-90.
45. Di Padova C, Worner TM, Lieber CS. The effect of abstinence on the blood acetaldehyde response to a test dose of alcohol in alcoholics. Alcohol Clin Exp Res 1987;11:559-61.
46. Shaw S, Rubin KP, Lieber CS. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease: Evidence of lipid peroxidation. Dig Dis Sci 1983;28:585-9.
47. Ma X, Svegliati-Baroni G, Poniachik J, Baraona E, Lieber CS. Collagen synthesis by liver stellate cells is released from its normal feedback regulation by acetaldehyde-induced modification of the carboxyl-terminal propeptide of procollagen. Alcohol Clin Exp Res 1997;21:1204-11.
48. Feo F, Pascale R, Garcea R, et al. Effect of the variations of S-adenosyl-L-methionine liver content on fat accumulation and ethanol metabolism in ethanol-intoxicated rats. Toxicol Appl Pharmacol 1986;83:331-41.
49. Lieber CS, Robins SJ, Leo MA. Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine. Alcohol Clin Exp Res 1994;18:592-5.
50. Lieber CS, Robins SJ, Li J, et al. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 1994;106:152-9.