-
1
-
-
77951673674
-
-
For a nice account on the discovery of the Ugi reaction see.
-
For a nice account on the discovery of the Ugi reaction see:, A. Dömling, Heterocycles 2007, 73, 1-11.
-
(2007)
Heterocycles
, vol.73
, pp. 1-11
-
-
Dömling, A.1
-
2
-
-
0001521573
-
-
I. Ugi, U. Meyr, U. Fetzer, C. Steinbrückner, Angew. Chem. 1959, 71, 386-388.
-
(1959)
Angew. Chem.
, vol.71
, pp. 386-388
-
-
Ugi, I.1
Meyr, U.2
Fetzer, U.3
Steinbrückner, C.4
-
3
-
-
0001605801
-
-
Mannich and Passerini, to whom we owe the two best-known three component reactions, are the grandparents of the four-component condensation, the Ugi reaction. Its parents are Ugi and Steinbrückner, assisted by co-workers of that period. The godparents are Optiz and Merz, McFarland and Sjöberg", cited in: The Passerini and Ugi Reactions.
-
"Mannich and Passerini, to whom we owe the two best-known three component reactions, are the grandparents of the four-component condensation, the Ugi reaction. Its parents are Ugi and Steinbrückner, assisted by co-workers of that period. The godparents are Optiz and Merz, McFarland and Sjöberg", cited in: The Passerini and Ugi Reactions, I. Ugi, S. Lohberger, R. Karl, Comprehensive Org. Synthesis 1991, 2, 1083-1109.
-
(1991)
Comprehensive Org. Synthesis
, vol.2
, pp. 1083-1109
-
-
Ugi, I.1
Lohberger, S.2
Karl, R.3
-
4
-
-
84875428919
-
-
For exhaustive reviews on Ugi reactions, see
-
For exhaustive reviews on Ugi reactions, see
-
-
-
-
5
-
-
2542509173
-
-
Angew. Chem. Int. Ed. 2000, 39, 3168 - 3210.
-
A. Dömling, I. Ugi, Angew. Chem. 2000, 112, 3300; Angew. Chem. Int. Ed. 2000, 39, 3168-3210.
-
(2000)
Angew. Chem.
, vol.112
, pp. 3300
-
-
Dömling, A.1
Ugi, I.2
-
6
-
-
84889290130
-
-
in: (Eds.:, Wiley & Sons, Hoboken, NJ, USA, 3-22.
-
I. Ugi, B. Werner, in: Methods and Reagents for Green Chemistry: An Introduction (Eds.:, P. Tundo, A. Perosa, F. Zecchini), Wiley & Sons, Hoboken, NJ, USA, 2007, pp. 3-22.
-
(2007)
Methods and Reagents for Green Chemistry: An Introduction
-
-
Ugi, I.1
Werner, B.2
Tundo, P.3
Perosa, A.4
Zecchini, F.5
-
7
-
-
0020211577
-
-
Angew. Chem. Int. Ed. Engl. 1982, 21, 810 - 819.
-
I. Ugi, Angew. Chem. 1982, 94, 826; Angew. Chem. Int. Ed. Engl. 1982, 21, 810-819.
-
(1982)
Angew. Chem.
, vol.94
, pp. 826
-
-
Ugi, I.1
-
9
-
-
84875458187
-
-
For interesting reviews on post-transformation strategies see
-
For interesting reviews on post-transformation strategies see
-
-
-
-
11
-
-
84890574887
-
-
in: (Eds.:, Wiley-VCH, Weinheim, Germany, 33-69.
-
S. Marcaccini, T. Torroba, in: Multicomponent Reactions (Eds.:, J. Zhu, H. Bienaymé), Wiley-VCH, Weinheim, Germany, 2005, pp. 33-69.
-
(2005)
Multicomponent Reactions
-
-
Marcaccini, S.1
Torroba, T.2
Zhu, J.3
Bienaymé, H.4
-
12
-
-
79959799404
-
-
in: (Eds.:, Springer-Verlag, Germany, 1-39.
-
L. Banfi, A. Basso, R. Riva, in: Synthesis of Heterocycles via Multicomponent Reactions I (Eds.:, R. V. A. Orru, E. Ruijter), Springer-Verlag, Germany, 2010, pp. 1-39.
-
(2010)
Synthesis of Heterocycles Via Multicomponent Reactions i
-
-
Banfi, L.1
Basso, A.2
Riva, R.3
Orru, R.V.A.4
Ruijter, E.5
-
14
-
-
84982338009
-
-
I. Ugi, K. Offermann, H. Herlinger, D. Marquarding, Justus Liebigs Ann. Chem. Ann. Chem. 1967, 709, 1-10.
-
(1967)
Justus Liebigs Ann. Chem. Ann. Chem.
, vol.709
, pp. 1-10
-
-
Ugi, I.1
Offermann, K.2
Herlinger, H.3
Marquarding, D.4
-
15
-
-
84856683089
-
-
N. Chéron, R. Ramozzi, L. El Kaïm, L. Grimaud, F. Fleurat-Lessard, J. Org. Chem. 2012, 77, 1361-1366.
-
(2012)
J. Org. Chem.
, vol.77
, pp. 1361-1366
-
-
Chéron, N.1
Ramozzi, R.2
El Kaïm, L.3
Grimaud, L.4
Fleurat-Lessard, F.5
-
16
-
-
84875470940
-
-
Intramolecular attack of the imino-anhydride intermediate, generated using a primary amine, by means of an hydroxy group, has been described in the reactions between α-amino acids, isocyanides, and glycolaldehyde dimer or homoserine, aldehydes, and isocyanides. In these cases the formation of the more stable six- and five-membered rings is favored instead of nitrogen-mediated transacylation to give the quite strained three-membered rings, see
-
Intramolecular attack of the imino-anhydride intermediate, generated using a primary amine, by means of an hydroxy group, has been described in the reactions between α-amino acids, isocyanides, and glycolaldehyde dimer or homoserine, aldehydes, and isocyanides. In these cases the formation of the more stable six- and five-membered rings is favored instead of nitrogen-mediated transacylation to give the quite strained three-membered rings, see
-
-
-
-
17
-
-
0001220302
-
-
Y. B. Kim, E. H. Choi, G. Keum, S. B. Kang, D. Lee, H. Y. Koh, Y. Kim, Org. Lett. 2001, 3, 4149-4152.
-
(2001)
Org. Lett.
, vol.3
, pp. 4149-4152
-
-
Kim, Y.B.1
Choi, E.H.2
Keum, G.3
Kang, S.B.4
Lee, D.5
Koh, H.Y.6
Kim, Y.7
-
18
-
-
0032563923
-
-
S. J. Park, G. Keum, S. B. Kang, H. Y. Koh, Y. Kim, Tetrahedron Lett. 1998, 39, 7109-7113.
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 7109-7113
-
-
Park, S.J.1
Keum, G.2
Kang, S.B.3
Koh, H.Y.4
Kim, Y.5
-
19
-
-
0347915136
-
-
with α-amino acids the cyclic imino-anhydride intermediate is attacked by the solvent, see:, Angew. Chem. Int. Ed. Engl. 1996, 35, 173 - 175.
-
with α-amino acids the cyclic imino-anhydride intermediate is attacked by the solvent, see:, A. Demharter, W. Hörl, E. Herdtweck, I. Ugi, Angew. Chem. 1996, 108, 185; Angew. Chem. Int. Ed. Engl. 1996, 35, 173-175.
-
(1996)
Angew. Chem.
, vol.108
, pp. 185
-
-
Demharter, A.1
Hörl, W.2
Herdtweck, E.3
Ugi, I.4
-
20
-
-
0030603133
-
-
I. Ugi, A. Demharter, W. Hörl, T. Schmid, Tetrahedron 1996, 52, 11657-11644.
-
(1996)
Tetrahedron
, vol.52
, pp. 11657-11644
-
-
Ugi, I.1
Demharter, A.2
Hörl, W.3
Schmid, T.4
-
21
-
-
84875449926
-
-
Isonitrile Chemistry (Ed.:, Academic Press, New York.
-
Isonitrile Chemistry (Ed.:, I. Ugi), Academic Press, New York, 1971.
-
(1971)
-
-
Ugi, I.1
-
24
-
-
84867051994
-
-
This observations were smartly exploited by Dömling in the synthesis of iminobisamides from α-amino acids, carbonyl compounds, isocyanides, and amines in methanol, see.
-
This observations were smartly exploited by Dömling in the synthesis of iminobisamides from α-amino acids, carbonyl compounds, isocyanides, and amines in methanol, see:, K. Khoury, M. K. Sinha, T. Nagashima, E. Herdtweck, A. Dömling, Angew. Chem. Int. Ed. 2012, 51, 10280-10283.
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 10280-10283
-
-
Khoury, K.1
Sinha, M.K.2
Nagashima, T.3
Herdtweck, E.4
Dömling, A.5
-
25
-
-
33746321616
-
-
Angew. Chem. Int. Ed. 2006, 45, 1099 - 1102.
-
G. B. Giovenzana, G. C. Tron, S. Di Paola, I. Menegotto, T. Pirali, Angew. Chem. 2006, 118, 1117; Angew. Chem. Int. Ed. 2006, 45, 1099-1102.
-
(2006)
Angew. Chem.
, vol.118
, pp. 1117
-
-
Giovenzana, G.B.1
Tron, G.C.2
Di Paola, S.3
Menegotto, I.4
Pirali, T.5
-
26
-
-
84898079899
-
-
Y. Huang, K. Khoury, A. Dömling, Top. Heterocycl. Chem. 2010, 23, 85-127.
-
(2010)
Top. Heterocycl. Chem.
, vol.23
, pp. 85-127
-
-
Huang, Y.1
Khoury, K.2
Dömling, A.3
-
27
-
-
82955240823
-
-
M. Bachman, S. E. Mann, T. D. Sheppard, Org. Biomol. Chem. 2012, 10, 162-170.
-
(2012)
Org. Biomol. Chem.
, vol.10
, pp. 162-170
-
-
Bachman, M.1
Mann, S.E.2
Sheppard, T.D.3
-
28
-
-
55449134131
-
-
T. Pirali, G. Callipari, E. Ercolano, A. A. Genazzani, G. B. Giovenzana, G. C. Tron, Org. Lett. 2008, 10, 4199-4202.
-
(2008)
Org. Lett.
, vol.10
, pp. 4199-4202
-
-
Pirali, T.1
Callipari, G.2
Ercolano, E.3
Genazzani, A.A.4
Giovenzana, G.B.5
Tron, G.C.6
-
29
-
-
79551500182
-
-
M. Sieńczyk, D. Podgorski, A. Blazejewska, J. Kulbacka, J. Saczko, J. Oleksyszyn, Bioorg. Med. Chem. 2011, 19, 1277-1284.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 1277-1284
-
-
Sieńczyk, M.1
Podgorski, D.2
Blazejewska, A.3
Kulbacka, J.4
Saczko, J.5
Oleksyszyn, J.6
-
30
-
-
61449102633
-
-
G. Piersanti, F. Remi, V. Fusi, M. Formica, G. Luca, G. Zappia, Org. Lett. 2009, 11, 417-420.
-
(2009)
Org. Lett.
, vol.11
, pp. 417-420
-
-
Piersanti, G.1
Remi, F.2
Fusi, V.3
Formica, M.4
Luca, G.5
Zappia, G.6
-
31
-
-
67649600781
-
-
R. Mossetti, T. Pirali, G. C. Tron, J. Org. Chem. 2009, 74, 4890-4892.
-
(2009)
J. Org. Chem.
, vol.74
, pp. 4890-4892
-
-
Mossetti, R.1
Pirali, T.2
Tron, G.C.3
-
32
-
-
0014127676
-
-
J. Hollowood, A. B. A. Jansen, P. J. Southgate, J. Med. Chem. 1967, 10, 863-867.
-
(1967)
J. Med. Chem.
, vol.10
, pp. 863-867
-
-
Hollowood, J.1
Jansen, A.B.A.2
Southgate, P.J.3
-
36
-
-
77950402397
-
-
R. Hili, V. Rai, A. K. Yudin, J. Am. Chem. Soc. 2010, 132, 2889-2891.
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 2889-2891
-
-
Hili, R.1
Rai, V.2
Yudin, A.K.3
-
37
-
-
80054744507
-
-
B. H. Rotstein, R. Mourtada, S. O. Kelely, A. K. Yudin, Chem. Eur. J. 2011, 17, 12257-12261.
-
(2011)
Chem. Eur. J.
, vol.17
, pp. 12257-12261
-
-
Rotstein, B.H.1
Mourtada, R.2
Kelely, S.O.3
Yudin, A.K.4
-
38
-
-
84860192173
-
-
B. H. Rotstein, D. J. Winternheimer, L. M. Yin, C. M. Deber, A. K. Yudin, Chem. Commun. 2012, 48, 3775-3777.
-
(2012)
Chem. Commun.
, vol.48
, pp. 3775-3777
-
-
Rotstein, B.H.1
Winternheimer, D.J.2
Yin, L.M.3
Deber, C.M.4
Yudin, A.K.5
-
42
-
-
0041417143
-
-
O. Mumm, H. Hesse, H. Volquartz, Ber. Dtsch. Chem. Ges. 1915, 48, 379-391.
-
(1915)
Ber. Dtsch. Chem. Ges.
, vol.48
, pp. 379-391
-
-
Mumm, O.1
Hesse, H.2
Volquartz, H.3
-
45
-
-
84875450694
-
-
[3,4a,4b,9]
-
[3,4a,4b,9]
-
-
-
-
46
-
-
33947332030
-
-
When an acid anhydride rearranges to another generalized acid anhydride, the latter is of less energy content than the former", cited from.
-
"When an acid anhydride rearranges to another generalized acid anhydride, the latter is of less energy content than the former", cited from:, C. D. Hurd, J. Chem. Educ. 1967, 44, 454-460.
-
(1967)
J. Chem. Educ.
, vol.44
, pp. 454-460
-
-
Hurd, C.D.1
-
48
-
-
79959791080
-
-
R. Mossetti, T. Pirali, D. Seggiorato, G. C. Tron, Chem. Commun. 2011, 47, 6966-6968.
-
(2011)
Chem. Commun.
, vol.47
, pp. 6966-6968
-
-
Mossetti, R.1
Pirali, T.2
Seggiorato, D.3
Tron, G.C.4
-
50
-
-
70349130818
-
-
With thioacids instead of carboxylic acids the same reaction occurs at room temperature, see.
-
With thioacids instead of carboxylic acids the same reaction occurs at room temperature, see, Y. Rao, X. Li, S. J. Danishefsky, J. Am. Chem. Soc. 2009, 131, 12924-12926.
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 12924-12926
-
-
Rao, Y.1
Li, X.2
Danishefsky, S.J.3
-
51
-
-
84875409609
-
-
2,3-Diaminoindoles with this substitution pattern have not been reported in the literature
-
2,3-Diaminoindoles with this substitution pattern have not been reported in the literature.
-
-
-
-
54
-
-
53349144936
-
-
Z. Mucsi, G. A. Chass, I. G. Csizmadia, J. Phys. Chem. B 2008, 112, 7885-7893.
-
(2008)
J. Phys. Chem. B
, vol.112
, pp. 7885-7893
-
-
Mucsi, Z.1
Chass, G.A.2
Csizmadia, I.G.3
-
55
-
-
84055193785
-
-
R. Mossetti, D. Saggiorato, G. C. Tron, J. Org. Chem. 2011, 76, 10258-10262.
-
(2011)
J. Org. Chem.
, vol.76
, pp. 10258-10262
-
-
Mossetti, R.1
Saggiorato, D.2
Tron, G.C.3
-
56
-
-
84875424654
-
-
US Patent 6927294- 2005.
-
US Patent 6927294- 2005.
-
-
-
-
57
-
-
84875456760
-
-
The road not taken: a selection of Robert Frost's poems, Henry Holt and Company, LLC, New York, 2002.
-
The road not taken: a selection of Robert Frost's poems, Henry Holt and Company, LLC, New York, 2002.
-
-
-
|