Aziridine-2-carboxaldehyde dimers undergo homo-Ugi 4-component-5-center reactions

Synthesis (Germany)

Volumn 44, Issue 18, 2012, Pages 2851-2858

  Rotstein, Benjamin H ^a   Yudin, Andrei K ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

aldehydes; amphoteric molecules; aziridines; heterocycles; multicomponent reactions

Indexed keywords

AZIRIDINES; HETEROCYCLES; MULTI-COMPONENT REACTIONS; NUCLEOPHILIC ATTACK;

ALDEHYDES;

ORGANIC COMPOUNDS;

2 [1 (2 AMINO 4,5 DIFLUOROBENZOYL) 3 ISOPROPYLAZIRIDIN 2 YL] N (TERT BUTYL) 2 MORPHOLINOACETAMIDE; 2 [1 BENZOYL 3 ISOPROPYLAZIRIDIN 2 YL] 2 (TERT BUTYL) 2 (PYRROLIDIN 1 YL)ACETAMIDE; 2 [1 BENZOYL 3 ISOPROPYLAZIRIDIN 2 YL] N (TERT BUTYL) 2 HYDROXYACETAMIDE; 6 ISOPROPYL 2 [3 ISOPROPYLAZIRIDIN 2 YL] 3 OXA 1 AZABICYCLO[3.1.0]HEXAN 4 OL; 6 METHYL 2 [3 METHYLAZIRIDIN 2 YL] 3 OXA 1 AZABICYCLO[3.1.0]HEXAN 4 OL; AZIRIDINE 2 CARBOXALDEHYDE; BETA ACYLAZIRIDINYL ALPHA AMINOAMIDE; DIMER; ETHYL 2 [2 [1 (2 BROMOBENZOYL) 3 ISOPROPYLAZIRIDIN 2 YL] 2 (PYRROLIDIN 1 YL)ACETAMIDO] 2 METHYLPROPANETHIOIC ACID; ETHYL 3 [2 [1 BENZOYLAZIRIDIN 2 YL] 2 MORPHOLINO ACETAMIDO]PROPANETHIOIC ACID; N (2 ISOPROPYL 4 MORPHOLINO 5 OXOTETRAHYDROFURAN 3 YL) 3 PHENYLPROPANAMIDE; N (2 ISOPROPYL 4 MORPHOLINO 5 OXOTETRAHYDROFURAN 3 YL)PROPIONAMIDE; N (TERT BUTYL) 2 (4 PHENYLPIPERIDIN 1 YL) 2 [1 PROPIONYLAZIRIDIN 2 YL]ACETAMIDE; N (TERT BUTYL) 2 (DIBENZYLAMINO) 2 [1 [2 (4 HYDROXYPHENYL)ACETYL]AZIRIDIN 2 YL]ACETAMIDE; N (TERT BUTYL) 2 (DIBENZYLAMINO) 2 [3 ISOPROPYL 1 NICOTINOYLAZIRIDIN 2 YL]ACETAMIDE; N (TERT BUTYL) 2 [1 [2 (4 HYDROXYPHENYL)ACETYL] 3 ISOPROPYLAZIRIDIN 2 YL] 2 (PYRROLIDIN 1 YL)ACETAMIDE; N (TERT BUTYL) 2 [1 [2 (4 HYDROXYPHENYL)ACETYL] 3 METHYLAZIRIDIN 2 YL] 2 (PYRROLIDIN 1 YL)ACETAMIDE; N (TERT BUTYL) 2 [1 [2 (4 HYDROXYPHENYL)ACETYL]AZIRIDIN 2 YL] 2 (PYRROLIDIN 1 YL)ACETAMIDE; N (TERT BUTYL) 2 [1 [2 (4 HYDROXYPHENYL)ACETYL]AZIRIDIN 2 YL] 2 MORPHOLINOACETAMIDE; N (TERT BUTYL) 2 [3 ISOPROPYL 1 (3 PHENYLPROPANOYL)AZIRIDIN 2 YL] 2 MORPHOLINOACETAMIDE; N (TERT BUTYL) 2 [3 ISOPROPYL 1 PROPIONYLAZIRIDIN 2 YL] 2 MORPHOLINOACETAMIDE; N (TERT BUTYL) 2 MORPHOLINO 2 [1 (4 NITROBENZOYL)AZIRIDIN 2 YL]ACETAMIDE; N [1 [AZIRIDIN 2 YL] 2 (TERT BUTYLAMINO) 2 OXOETHYL] N BENZYLBENZAMIDE; N [2 [6 (DIMETHYLAMINO) 1,3 DIOXO 1H BENZO[DE]ISOQUINOLIN 2(3H) YL]ETHYL] 2 (1 NICOTINOYLAZIRIDIN 2 YL) 2 (PYRROLIDIN 1 YL)ACETAMIDE; N BENZYL 2 [3 ISOPROPYL 1 [2 (THIOPHEN 3 YL)ACETYL]AZIRIDIN 2 YL] 2 (PIPERIDIN 1 YL)ACETAMIDE; TERT BUTYL 2 ISOPROPYLAZIRIDINE 1 CARBOXYLIC ACID; TERT BUTYL 2 METHYLAZIRIDINE 1 CARBOXYLIC ACID; TERT BUTYL 3 ISOPROPYLAZIRIDINE 2 CARBOXYLIC ACID; TERT BUTYL 3 METHYLAZIRIDINE 2 CARBOXYLIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; HOMO UGI 4 COMPONENT 5 CENTER REACTION; NUCLEOPHILICITY; PASSERINI REACTION; SUBSTITUTION REACTION; UGI REACTION;

EID: 84866101950     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260261     Document Type: Article

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