Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 8, 2013, Pages 2414-2421

  Venier, Olivier ^a   Pascal, Cécile ^a   Braun, Alain ^a   Namane, Claudie ^a   Mougenot, Patrick ^a   Crespin, Olivier ^a   Pacquet, François ^a   Mougenot, Cécile ^a   Monseau, Catherine ^a   Onofri, Bénédicte ^a   Dadji Faïhun, Rommel ^a   Leger, Céline ^a   Ben Hassine, Majdi ^a   Van Pham, Thao ^a   Ragot, Jean Luc ^a   Philippo, Christophe ^a   Farjot, Géraldine ^a   Noah, Lionel ^a   Maniani, Karima ^a   Boutarfa, Asma ^a   Nicolaï, Eric ^a   Guillot, Etienne ^a   Pruniaux, Marie Pierre ^a   Güssregen, Stefan ^b   Engel, Christian ^b   Coutant, Anne Laure ^a   De Miguel, Beatriz ^c   Castro, Antonio ^c   more..

^a SANOFI   (France)

^b Sanofi Deutschland GmbH   (Germany)

^c R and D   (Spain)

Author keywords

11 HSD1 inhibitors; 11 Hydroxysteroid dehydrogenase type I; Adamantane urea; DIO model; Metabolic syndrome; Pharmacodynamic ex vivo assay

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ADAMANTANE; ENZYME INHIBITOR; SAR 184841; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DISEASE MODEL; DRUG SYNTHESIS; ENZYME INHIBITION; IN VIVO STUDY; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADAMANTANE; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, TRANSGENIC; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; RODENTIA;

EID: 84875448220     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.018     Document Type: Article

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