Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents

Journal of Natural Products

Volumn 76, Issue 3, 2013, Pages 354-367

  Hwang, Jae Min ^a   Oh, Taegwon ^b   Kaneko, Takushi ^c   Upton, Anna M ^c   Franzblau, Scott G ^d   Ma, Zhenkun ^c   Cho, Sang Nae ^b   Kim, Pilho ^a,e  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e University of Science and Technology (UST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMOINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 2 NITROINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 8 (TRIFLUOROMETHOXY)INDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 8 AMINOINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 8 BROMOINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 8 CHLORO 2 FLUOROINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 8 CHLORO 3 FLUOROINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 8 CHLOROINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 8 FLUOROINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 8 METHOXYINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 8 NITROINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 9 (PIPERAZIN 1 YL)INDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 9 (PYRROLIDIN 1 YL)INDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; 9 CHLOROINDOLO[2,1 B] 4 AZAQUINAZOLINE 6,12 DIONE; 9 CHLOROINDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; ETHYL 6,12 DIOXO 6,12 DIHYDROINDOLO[2,1 B]QUINAZOLINE 8 CARBOXYLATE; INDOLO[2,1 B]QUINAZOLINE 6,12 DIONE; TRYPTANTHRIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; HUMANS; MICE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; QUINAZOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBERCULOSIS;

ANIMALIA; MURINAE; MYCOBACTERIUM TUBERCULOSIS; RODENTIA;

EID: 84875447628     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np3007167     Document Type: Article

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