Proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on human chronic myeloid leukemia K562 cell line in vitro

International Journal of Molecular Sciences

Volumn 12, Issue 6, 2011, Pages 3831-3845

  Miao, Shan ^a   Shi, Xiaopeng ^b   Zhang, Hai ^c   Wang, Siwang ^a   Sun, Jiyuan ^a   Hua, Wei ^b   Miao, Qing ^a   Zhao, Yong ^c   Zhang, Caiqin ^c  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c Laboratory Animal Research Center   (China)

Author keywords

Apoptosis; Chronic myeloid leukemia; K562 cells; Proliferation; Tryptanthrin

Indexed keywords

ANTILEUKEMIC AGENT; CASPASE 3; CELL PROTEIN; CYCLOPHOSPHAMIDE; PROCASPASE 3; PROTEIN BCL 2; PROTEIN CYT C; TRYPTANTHRIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CYTOCHROME C; PEPTIDE CHLOROMETHYL KETONE; PROTEIN BAX; QUINAZOLINE DERIVATIVE; TRYPTANTHRINE;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DAMAGE; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN K 562; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHRONIC MYELOID LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; DNA FRAGMENTATION; DRUG EFFECTS; K562 CELL LINE; METABOLISM; MITOCHONDRION; PATHOLOGY;

VASCONCELLEA CANDICANS;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL PROLIFERATION; CYTOCHROMES C; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINAZOLINES;

EID: 79959691978     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12063831     Document Type: Article

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