Tolerance to nitroglycerin through proteasomal down-regulation of aldehyde dehydrogenase-2 in a genetic mouse model of ascorbate deficiency

British Journal of Pharmacology

Volumn 168, Issue 8, 2013, Pages 1868-1877

  Wolkart G ^a   Beretta, M ^a   Wenzl, M V ^a   Stessel, H ^a   Schmidt, K ^a   Maeda, N ^b   Mayer, B ^a   Schrammel, A ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

aldehyde dehydrogenase 2; ascorbate deficiency; bortezomib; genetic mouse model; nitrate tolerance; nitroglycerin; proteasomal degradation; vascular relaxation; vitamin C

Indexed keywords

ACETYLCHOLINE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ASCORBIC ACID; BORTEZOMIB; GLYCERYL TRINITRATE; MESSENGER RNA; NITRIC OXIDE; OXIDOREDUCTASE; PROTEASOME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; XANTHINE OXIDASE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; BORONIC ACID DERIVATIVE; PYRAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AORTA; ARTICLE; ASCORBIC ACID DEFICIENCY; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOWN REGULATION; DRUG ACTIVATION; DRUG TOLERANCE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME METABOLISM; FEMALE; GENE EXPRESSION; IMMUNOBLOTTING; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; UBIQUITINATION; VASODILATATION; ANIMAL; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TRANSGENIC MOUSE;

ALDEHYDE DEHYDROGENASE; ANIMALS; AORTA; ASCORBIC ACID DEFICIENCY; BORONIC ACIDS; DRUG TOLERANCE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; NITROGLYCERIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRAZINES; UBIQUITINATION;

EID: 84875446341     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12081     Document Type: Article

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