Nitrate tolerance does not increase production of peroxynitrite in the heart

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 283, Issue 1 52-1, 2002, Pages

  Csont, Tamás ^a,b   Csonka, Csaba ^a,b   Ónody, Annamária ^a,b   Görbe, Anikó ^a,b   Dux, László ^a,b   Schulz, Richard ^a,b   Baxter, Gary F ^a,b   Ferdinandy, Péter ^a,b,c  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF ALBERTA   (Canada)

^c ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Myocardium; Nitric oxide; Nitroglycerin; Reactive oxygen species

Indexed keywords

GLYCERYL TRINITRATE; NITRATE; NITRIC OXIDE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ISCHEMIC HEART DISEASE; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0036307613     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00817.2001     Document Type: Article

References (42)

1. The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion
2. Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway
3. Dietary supplement with vitamin C prevents nitrate tolerance
4. A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues
5. Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts
6. Lack of correlation between myocardial nitric oxide and cyclic guanosine monophosphate content in both nitrate-tolerant and -nontolerant rats
7. ATP
8. Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: Effect of vitamin C
9. Formation of reactive oxygen species in various vascular cells during glyceryltrinitrate metabolism
10. Formation of reactive oxygen species by pentaerithrityltetranitrate and glyceryl trinitrate in vitro and development of nitrate tolerance
11. The role of xanthine oxidase during myocardial ischemia in several species including man
12. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
13. Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure
14. Peroxynitrite: Toxic or protective in the heart?
15. Adaptation to myocardial stress in disease states: Is preconditioning a healthy heart phenomenon?
16. Nitroglycerin-induced direct protection of the ischaemic myocardium in isolated working hearts of rats with vascular tolerance to nitroglycerin
17. Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction
18. Tyrosine nitration by simultaneous generation of (·)NO and O-(2) under physiological conditions. How the radicals do the job
19. Immunohistological detection of gap junctions in human lymphoid tissue: Connexin 43 in follicular dendritic and lymphoendothelial cells
20. In vivo nitrate tolerance is not associated with reduced bioconversion of nitroglycerin to nitric oxide
21. Vascular peroxynitrite formation during organic nitrate tolerance
22. Role of superoxide dismutase in in vivo and in vitro nitrate tolerance
23. Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability
24. Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance
25. Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale postinfarction studies
26. Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning
27. Nitrate therapy for stable angina pectoris
28. Lack of tyrosine nitration by peroxynitrite generated at physiological pH
29. Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite. Implications for tyrosine modification by nitric oxide/superoxide in vivo
30. Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite
31. Nitroglycerin tolerance in human vessels: Evidence for impaired nitroglycerin bioconversion
32. Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency
33. Induction and potential biological relevance of a Ca(2+)-independent nitric oxide synthase in the myocardium
34. Paracrine and autocrine effects of nitric oxide on myocardial function
35. Reversal or nitroglycerin tolerance by the cGMP phosphodiesterase inhibitor zaprinast
36. Loss of preconditioning in rabbits with vascular tolerance to nitroglycerin
37. Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism
38. Long-term nitrate use in chronic coronary artery disease: Need for a randomized controlled trial
39. Tissue levels of glyceryl trinitrate and cGMP after in vivo administration in rat, and the effect of tolerance development
40. Comparisons of ESR and HPLC methods for the detection of OH·radicals in ischemic/reperfused hearts: A relationship between the genesis of free radicals and reperfusion arrhythmias
41. Tyrosine modification by reactive nitrogen species: A closer look
42. Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts