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Volumn 36, Issue 4, 2013, Pages 1047-1055

Type 2 diabetes: Etiology and reversibility

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL ACYLTRANSFERASE 1; GLUCOSE; INSULIN; ORAL ANTIDIABETIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 84875439992     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-1805     Document Type: Review
Times cited : (317)

References (99)
  • 1
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
    • UK Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, Holman RR; UK Prospective Diabetes Study (UKPDS) Group. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA 1999;281: 2005-2012
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 2
    • 84861443900 scopus 로고    scopus 로고
    • Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes
    • Petersen KF, Dufour S, Morino K, Yoo PS, Cline GW, Shulman GI. Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes. Proc Natl Acad Sci U S A 2012;109:8236-8240
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 8236-8240
    • Petersen, K.F.1    Dufour, S.2    Morino, K.3    Yoo, P.S.4    Cline, G.W.5    Shulman, G.I.6
  • 4
    • 64749109223 scopus 로고    scopus 로고
    • Primary defects in beta-cell function further exacerbated by worsening of insulin resistance mark the development of impaired glucose tolerance in obese adolescents
    • CaliAM, ManCD, Cobelli C, et al. Primary defects in beta-cell function further exacerbated by worsening of insulin resistance mark the development of impaired glucose tolerance in obese adolescents. Diabetes Care 2009;32:456-461
    • (2009) Diabetes Care , vol.32 , pp. 456-461
    • Mancd, C.1    Cobelli, C.2
  • 5
    • 0033968126 scopus 로고    scopus 로고
    • Insulin resistance differentially affects the PI 3-kinase-and MAP kinase-mediated signaling in human muscle
    • Cusi K, Maezono K, Osman A, et al. Insulin resistance differentially affects the PI 3-kinase-and MAP kinase-mediated signaling in human muscle. J Clin Invest 2000;105:311-320
    • (2000) J Clin Invest , vol.105 , pp. 311-320
    • Cusi, K.1    Maezono, K.2    Osman, A.3
  • 6
    • 33745848775 scopus 로고    scopus 로고
    • Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
    • Herman MA, Kahn BB. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest 2006;116:1767-1775
    • (2006) J Clin Invest , vol.116 , pp. 1767-1775
    • Herman, M.A.1    Kahn, B.B.2
  • 7
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid-induced insulin resistance in humans
    • Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 1996;97:2859-2865
    • (1996) J Clin Invest , vol.97 , pp. 2859-2865
    • Roden, M.1    Price, T.B.2    Perseghin, G.3
  • 9
    • 84866405516 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low nonstimulating glucose concentration
    • Roma LP, Pascal SM, Duprez J, Jonas JC. Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low nonstimulating glucose concentration. Diabetologia 2012;55:2226-2237
    • (2012) Diabetologia , vol.55 , pp. 2226-2237
    • Roma, L.P.1    Pascal, S.M.2    Duprez, J.3    Jonas, J.C.4
  • 10
    • 45249122276 scopus 로고    scopus 로고
    • Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes
    • Cnop M. Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem Soc Trans 2008;36:348-352
    • (2008) Biochem Soc Trans , vol.36 , pp. 348-352
    • Cnop, M.1
  • 11
    • 9444285818 scopus 로고    scopus 로고
    • Twelve-and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
    • Ahrén B, Gomis R, Standl E, Mills D, Schweizer A. Twelve-and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care 2004;27:2874-2880
    • (2004) Diabetes Care , vol.27 , pp. 2874-2880
    • Ahrén, B.1    Gomis, R.2    Standl, E.3    Mills, D.4    Schweizer, A.5
  • 12
    • 0026500361 scopus 로고
    • Surgical treatment of obesity and its effect on diabetes: 10-y follow-up
    • Pories WJ, MacDonald KG Jr, Morgan EJ, et al. Surgical treatment of obesity and its effect on diabetes: 10-y follow-up. Am J Clin Nutr 1992;55(Suppl.):582S-585SS
    • (1992) Am J Clin Nutr , vol.55 , Issue.SUPPL.
    • Pories, W.J.1    MacDonald Jr., K.G.2    Morgan, E.J.3
  • 13
    • 38349136266 scopus 로고    scopus 로고
    • Adjustable gastric banding and conventional therapy for type 2 diabetes: A randomized controlled trial
    • Dixon JB, O'Brien PE, Playfair J, et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 2008; 299:316-323
    • (2008) JAMA , vol.299 , pp. 316-323
    • Dixon, J.B.1    O'Brien, P.E.2    Playfair, J.3
  • 14
    • 64749088645 scopus 로고    scopus 로고
    • Impact of different bariatric surgical procedures on insulin action and beta-cell function in type 2 diabetes
    • Ferrannini E, Mingrone G. Impact of different bariatric surgical procedures on insulin action and beta-cell function in type 2 diabetes. Diabetes Care 2009;32:514-520
    • (2009) Diabetes Care , vol.32 , pp. 514-520
    • Ferrannini, E.1    Mingrone, G.2
  • 15
    • 33747038162 scopus 로고    scopus 로고
    • Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery
    • Guidone C, Manco M, Valera-Mora E, et al. Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery. Diabetes 2006;55:2025-2031
    • (2006) Diabetes , vol.55 , pp. 2025-2031
    • Guidone, C.1    Manco, M.2    Valera-Mora, E.3
  • 16
    • 33750331204 scopus 로고    scopus 로고
    • The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes
    • Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg 2006;244:741-749
    • (2006) Ann Surg , vol.244 , pp. 741-749
    • Rubino, F.1    Forgione, A.2    Cummings, D.E.3
  • 17
    • 80052904102 scopus 로고    scopus 로고
    • Postprandial insulin secretion after gastric bypass surgery: The role of glucagon-like peptide 1
    • Holst JJ. Postprandial insulin secretion after gastric bypass surgery: the role of glucagon-like peptide 1. Diabetes 2011; 60:2203-2205
    • (2011) Diabetes , vol.60 , pp. 2203-2205
    • Holst, J.J.1
  • 18
    • 0038513551 scopus 로고    scopus 로고
    • Measurement of total energy expenditure in grossly obese women: Comparison of the bicarbonate-urea method with whole-body calorimetry and freeliving doubly labelledwater
    • Gibney ER, Murgatroyd P, Wright A, Jebb S, Elia M. Measurement of total energy expenditure in grossly obese women: comparison of the bicarbonate-urea method with whole-body calorimetry and freeliving doubly labelledwater. Int JObesRelat Metab Disord 2003;27:641-647
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 641-647
    • Gibney, E.R.1    Murgatroyd, P.2    Wright, A.3    Jebb, S.4    Elia, M.5
  • 19
    • 33748420556 scopus 로고    scopus 로고
    • Preoperative weight loss with a very-low-energy diet: Quantitation of changes in liver and abdominal fat by serial imaging
    • Colles SL, Dixon JB, Marks P, Strauss BJ, O'Brien PE. Preoperative weight loss with a very-low-energy diet: quantitation of changes in liver and abdominal fat by serial imaging. Am J Clin Nutr 2006;84: 304-311
    • (2006) Am J Clin Nutr , vol.84 , pp. 304-311
    • Colles, S.L.1    Dixon, J.B.2    Marks, P.3    Strauss, B.J.4    O'Brien, P.E.5
  • 20
    • 14644435731 scopus 로고    scopus 로고
    • Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 2005;54:603-608
    • (2005) Diabetes , vol.54 , pp. 603-608
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Lehrke, M.4    Hendler, R.E.5    Shulman, G.I.6
  • 21
    • 80054091845 scopus 로고    scopus 로고
    • Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    • Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011;54:2506-2514
    • (2011) Diabetologia , vol.54 , pp. 2506-2514
    • Lim, E.L.1    Hollingsworth, K.G.2    Aribisala, B.S.3    Chen, M.J.4    Mathers, J.C.5    Taylor, R.6
  • 22
    • 34547514221 scopus 로고    scopus 로고
    • Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
    • Gastaldelli A, Cusi K, Pettiti M, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 2007;133:496-506
    • (2007) Gastroenterology , vol.133 , pp. 496-506
    • Gastaldelli, A.1    Cusi, K.2    Pettiti, M.3
  • 23
    • 51249092912 scopus 로고    scopus 로고
    • Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content
    • Ravikumar B, Gerrard J, Dalla Man C, et al. Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content. Diabetes 2008;57: 2288-2295
    • (2008) Diabetes , vol.57 , pp. 2288-2295
    • Ravikumar, B.1    Gerrard, J.2    Dalla Man, C.3
  • 24
    • 33748291464 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets
    • Lalloyer F, Vandewalle B, Percevault F, et al. Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. Diabetes 2006;55:1605-1613
    • (2006) Diabetes , vol.55 , pp. 1605-1613
    • Lalloyer, F.1    Vandewalle, B.2    Percevault, F.3
  • 26
    • 34547911800 scopus 로고    scopus 로고
    • The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
    • Petersen KF, Dufour S, Savage DB, et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A 2007;104:12587-12594
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12587-12594
    • Petersen, K.F.1    Dufour, S.2    Savage, D.B.3
  • 27
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Brüning JC, Michael MD, Winnay JN, et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 1998;2: 559-569
    • (1998) Mol Cell , vol.2 , pp. 559-569
    • Brüning, J.C.1    Michael, M.D.2    Winnay, J.N.3
  • 28
    • 38849204124 scopus 로고    scopus 로고
    • A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice [published Correction In: Plos Med 2008; 5:e246]
    • Savage DB, Zhai L, Ravikumar B, et al. A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice [published correction in: Plos Med 2008; 5:e246]. PLoS Med 2008;5:e27
    • (2008) PLoS Med , vol.5
    • Savage, D.B.1    Zhai, L.2    Ravikumar, B.3
  • 29
    • 84859524682 scopus 로고    scopus 로고
    • Insulin resistance and type 2 diabetes
    • Taylor R. Insulin resistance and type 2 diabetes. Diabetes 2012;61:778-779
    • (2012) Diabetes , vol.61 , pp. 778-779
    • Taylor, R.1
  • 30
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004;350:664-671
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 31
    • 33845947550 scopus 로고    scopus 로고
    • Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetesmellitus and BMI-matched control subjects
    • Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, et al. Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetesmellitus and BMI-matched control subjects. Diabetologia 2007;50: 113-120
    • (2007) Diabetologia , vol.50 , pp. 113-120
    • Schrauwen-Hinderling, V.B.1    Kooi, M.E.2    Hesselink, M.K.3
  • 32
    • 33644746318 scopus 로고    scopus 로고
    • Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle
    • Brehm A, Krssak M, Schmid AI, Nowotny P, Waldhäusl W, Roden M. Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle. Diabetes 2006;55:136-140
    • (2006) Diabetes , vol.55 , pp. 136-140
    • Brehm, A.1    Krssak, M.2    Schmid, A.I.3    Nowotny, P.4    Waldhäusl, W.5    Roden, M.6
  • 33
    • 79956219698 scopus 로고    scopus 로고
    • Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates
    • Lim EL, Hollingsworth KG, Smith FE, Thelwall PE, Taylor R. Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates. Clin Sci (Lond) 2011;121:169-177
    • (2011) Clin Sci (Lond) , vol.121 , pp. 169-177
    • Lim, E.L.1    Hollingsworth, K.G.2    Smith, F.E.3    Thelwall, P.E.4    Taylor, R.5
  • 34
    • 78651480268 scopus 로고    scopus 로고
    • Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy
    • Lim EL, Hollingsworth KG, Thelwall PE, Taylor R. Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy. NMR Biomed 2010;23:952-957
    • (2010) NMR Biomed , vol.23 , pp. 952-957
    • Lim, E.L.1    Hollingsworth, K.G.2    Thelwall, P.E.3    Taylor, R.4
  • 35
    • 0342314436 scopus 로고    scopus 로고
    • Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients
    • Ryysy L, Häkkinen A-M, Goto T, et al. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 2000;49:749-758
    • (2000) Diabetes , vol.49 , pp. 749-758
    • Ryysy, L.1    Häkkinen, A.-M.2    Goto, T.3
  • 36
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • Seppälä-Lindroos A, Vehkavaara S, Häkkinen AM, et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002;87:3023-3028
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3023-3028
    • Seppälä-Lindroos, A.1    Vehkavaara, S.2    Häkkinen, A.M.3
  • 37
    • 84866621997 scopus 로고    scopus 로고
    • Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
    • Sevastianova K, Santos A, Kotronen A, et al. Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr 2012;96:727-734
    • (2012) Am J Clin Nutr , vol.96 , pp. 727-734
    • Sevastianova, K.1    Santos, A.2    Kotronen, A.3
  • 38
    • 0037216466 scopus 로고    scopus 로고
    • Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
    • Schwarz JM, Linfoot P, Dare D, Aghajanian K. Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr 2003;77: 43-50
    • (2003) Am J Clin Nutr , vol.77 , pp. 43-50
    • Schwarz, J.M.1    Linfoot, P.2    Dare, D.3    Aghajanian, K.4
  • 39
    • 80051971972 scopus 로고    scopus 로고
    • Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals
    • Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. ProcNatl Acad Sci U S A 2011;108:13705-13709
    • (2011) ProcNatl Acad Sci U S A , vol.108 , pp. 13705-13709
    • Rabøl, R.1    Petersen, K.F.2    Dufour, S.3    Flannery, C.4    Shulman, G.I.5
  • 40
    • 28444437414 scopus 로고    scopus 로고
    • Reduced intrahepatic fat content is associated with increased whole-body lipid oxidation in patients with type 1 diabetes
    • Perseghin G, Lattuada G, De Cobelli F, et al. Reduced intrahepatic fat content is associated with increased whole-body lipid oxidation in patients with type 1 diabetes. Diabetologia 2005;48:2615-262
    • (2005) Diabetologia , vol.48 , pp. 2615-2621
    • Perseghin, G.1    Lattuada, G.2    De Cobelli, F.3
  • 42
    • 35148872178 scopus 로고    scopus 로고
    • Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children
    • Nobili V, Marcellini M, Marchesini G, et al. Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children. Diabetes Care 2007;30:2638-2640
    • (2007) Diabetes Care , vol.30 , pp. 2638-2640
    • Nobili, V.1    Marcellini, M.2    Marchesini, G.3
  • 43
    • 33847613579 scopus 로고    scopus 로고
    • Habitual physical activity is associated with intrahepatic fat content in humans
    • Perseghin G, Lattuada G, De Cobelli F, et al. Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care 2007;30:683-688
    • (2007) Diabetes Care , vol.30 , pp. 683-688
    • Perseghin, G.1    Lattuada, G.2    De Cobelli, F.3
  • 44
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006;355:2297-230
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 45
    • 70350043496 scopus 로고    scopus 로고
    • Abnormal hepatic energy homeostasis in type 2 diabetes
    • Szendroedi J, Chmelik M, Schmid AI, et al. Abnormal hepatic energy homeostasis in type 2 diabetes. Hepatology 2009;50:1079-1086
    • (2009) Hepatology , vol.50 , pp. 1079-1086
    • Szendroedi, J.1    Chmelik, M.2    Schmid, A.I.3
  • 46
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: Unravelling the mechanism
    • Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet 2010; 375:2267-2277
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 47
    • 33644654777 scopus 로고    scopus 로고
    • Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
    • Savage DB, Choi CS, Samuel VT, et al. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J Clin Invest 2006; 116:817-824
    • (2006) J Clin Invest , vol.116 , pp. 817-824
    • Savage, D.B.1    Choi, C.S.2    Samuel, V.T.3
  • 48
    • 84861647226 scopus 로고    scopus 로고
    • Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
    • Magkos F, Su X, Bradley D, et al. Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology 2012; 142:1444-1446
    • (2012) Gastroenterology , vol.142 , pp. 1444-1446
    • Magkos, F.1    Su, X.2    Bradley, D.3
  • 49
    • 80053627289 scopus 로고    scopus 로고
    • Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
    • Kumashiro N, Erion DM, Zhang D, et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 2011;108:16381-16385
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 16381-16385
    • Kumashiro, N.1    Erion, D.M.2    Zhang, D.3
  • 50
    • 9444262473 scopus 로고    scopus 로고
    • Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes
    • Krssak M, Brehm A, Bernroider E, et al. Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes 2004;53:3048-3056
    • (2004) Diabetes , vol.53 , pp. 3048-3056
    • Krssak, M.1    Brehm, A.2    Bernroider, E.3
  • 52
    • 33747077203 scopus 로고    scopus 로고
    • NAFLD in children: A prospective clinicalpathological study and effect of lifestyle advice
    • Nobili V, Marcellini M, Devito R, et al. NAFLD in children: a prospective clinicalpathological study and effect of lifestyle advice. Hepatology 2006;44:458-465
    • (2006) Hepatology , vol.44 , pp. 458-465
    • Nobili, V.1    Marcellini, M.2    Devito, R.3
  • 53
    • 29944445284 scopus 로고    scopus 로고
    • Increased intramuscular lipid storage in the insulinresistant and endurance-trained state
    • van Loon LJ, Goodpaster BH. Increased intramuscular lipid storage in the insulinresistant and endurance-trained state. Pflugers Arch 2006;451:606-616
    • (2006) Pflugers Arch , vol.451 , pp. 606-616
    • Van Loon, L.J.1    Goodpaster, B.H.2
  • 54
    • 70350545945 scopus 로고    scopus 로고
    • Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1
    • Liu L, Shi X, Choi CS, et al. Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. Diabetes 2009;58: 2516-2524
    • (2009) Diabetes , vol.58 , pp. 2516-2524
    • Liu, L.1    Shi, X.2    Choi, C.S.3
  • 55
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008;40:1461-1465
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 56
    • 70350550096 scopus 로고    scopus 로고
    • Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    • Kantartzis K, Peter A, Machicao F, et al. Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 2009;58:2616-2623
    • (2009) Diabetes , vol.58 , pp. 2616-2623
    • Kantartzis, K.1    Peter, A.2    MacHicao, F.3
  • 57
    • 36049000864 scopus 로고    scopus 로고
    • Pancreatic fat content and beta-cell function in men with and without type 2 diabetes
    • Tushuizen ME, Bunck MC, Pouwels PJ, et al. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 2007;30:2916-292
    • (2007) Diabetes Care , vol.30 , pp. 2916-2921
    • Tushuizen, M.E.1    Bunck, M.C.2    Pouwels, P.J.3
  • 58
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulindependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
    • Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. Beta-cell lipotoxicity in the pathogenesis of non-insulindependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A 1994;91: 10878-10882
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10878-10882
    • Lee, Y.1    Hirose, H.2    Ohneda, M.3    Johnson, J.H.4    McGarry, J.D.5    Unger, R.H.6
  • 59
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002; 51:7-18
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 60
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995;44:863-870
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 61
    • 12744274513 scopus 로고    scopus 로고
    • Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion
    • Noushmehr H, D'Amico E, Farilla L, et al. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. Diabetes 2005;54:472-481
    • (2005) Diabetes , vol.54 , pp. 472-481
    • Noushmehr, H.1    D'Amico, E.2    Farilla, L.3
  • 62
    • 34547888676 scopus 로고    scopus 로고
    • Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells
    • Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG. Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol 2007;194:283-291
    • (2007) J Endocrinol , vol.194 , pp. 283-291
    • Diakogiannaki, E.1    Dhayal, S.2    Childs, C.E.3    Calder, P.C.4    Welters, H.J.5    Morgan, N.G.6
  • 63
    • 0029849247 scopus 로고    scopus 로고
    • Fasting and decreased B cell sensitivity: Important role for fatty acid-induced inhibition of PDH activity
    • Zhou YP, Priestman DA, Randle PJ, Grill VE. Fasting and decreased B cell sensitivity: important role for fatty acid-induced inhibition of PDH activity. Am J Physiol 1996;270:E988-E994
    • (1996) Am J Physiol , vol.270
    • Zhou, Y.P.1    Priestman, D.A.2    Randle, P.J.3    Grill, V.E.4
  • 64
    • 84857435669 scopus 로고    scopus 로고
    • Free fatty acids block glucose-induced b-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18
    • Pascoe J, Hollern D, Stamateris R, et al. Free fatty acids block glucose-induced b-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18. Diabetes 2012;61:632-641
    • (2012) Diabetes , vol.61 , pp. 632-641
    • Pascoe, J.1    Hollern, D.2    Stamateris, R.3
  • 65
    • 0028833276 scopus 로고
    • Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence
    • Ohneda M, Inman LR, Unger RH. Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence. Diabetologia 1995;38:173-179
    • (1995) Diabetologia , vol.38 , pp. 173-179
    • Ohneda, M.1    Inman, L.R.2    Unger, R.H.3
  • 68
    • 0032484132 scopus 로고    scopus 로고
    • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression
    • ShimabukuroM, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem 1998;273: 32487-32490
    • (1998) J Biol Chem , vol.273 , pp. 32487-32490
    • Shimabukurom Higa, M.1    Zhou, Y.T.2    Wang, M.Y.3    Newgard, C.B.4    Unger, R.H.5
  • 69
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
    • Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 1998;95:2498-250
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 70
    • 77958040076 scopus 로고    scopus 로고
    • Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
    • Butler AE, Cao-Minh L, Galasso R, et al. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia 2010;53: 2167-2176
    • (2010) Diabetologia , vol.53 , pp. 2167-2176
    • Butler, A.E.1    Cao-Minh, L.2    Galasso, R.3
  • 71
    • 84861914948 scopus 로고    scopus 로고
    • Maintenance of b-cell maturity and plasticity in the adult pancreas: Developmental biology concepts in adult physiology
    • SzabatM, Lynn FC, Hoffman BG, Kieffer TJ, Allan DW, Johnson JD. Maintenance of b-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes 2012;61: 1365-1371
    • (2012) Diabetes , vol.61 , pp. 1365-1371
    • Szabatm Lynn, F.C.1    Hoffman, B.G.2    Kieffer, T.J.3    Allan, D.W.4    Johnson, J.D.5
  • 72
    • 84868110769 scopus 로고    scopus 로고
    • Pancreatic steatosis and its relationship to b-cell dysfunction in humans: Racial and ethnic variations
    • Szczepaniak LS, Victor RG, Mathur R, et al. Pancreatic steatosis and its relationship to b-cell dysfunction in humans: racial and ethnic variations. Diabetes Care 2012;35:2377-2383
    • (2012) Diabetes Care , vol.35 , pp. 2377-2383
    • Szczepaniak, L.S.1    Victor, R.G.2    Mathur, R.3
  • 73
    • 0020028531 scopus 로고
    • Comparison of insulin secretion and in vivo insulin action in nonobese and moderately obese individuals with noninsulin-dependent diabetes mellitus
    • Reaven GM, Doberne L, Greenfield MS. Comparison of insulin secretion and in vivo insulin action in nonobese and moderately obese individuals with noninsulin-dependent diabetes mellitus. Diabetes 1982;31:382-384
    • (1982) Diabetes , vol.31 , pp. 382-384
    • Reaven, G.M.1    Doberne, L.2    Greenfield, M.S.3
  • 74
    • 36048934639 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes inmiddleaged Japanese men
    • Shibata M, Kihara Y, Taguchi M, Tashiro M, Otsuki M. Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes inmiddleaged Japanese men.Diabetes Care 2007;30: 2940-2944
    • (2007) Diabetes Care , vol.30 , pp. 2940-2944
    • Shibata, M.1    Kihara, Y.2    Taguchi, M.3    Tashiro, M.4    Otsuki, M.5
  • 75
    • 34047098736 scopus 로고    scopus 로고
    • Serial metabolic measurements and conversion to type 2 diabetes in the west of Scotland coronary prevention study: Specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor
    • Sattar N, McConnachie A, Ford I, et al. Serial metabolic measurements and conversion to type 2 diabetes in the west of Scotland coronary prevention study: specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor. Diabetes 2007;56:984-991
    • (2007) Diabetes , vol.56 , pp. 984-991
    • Sattar, N.1    McConnachie, A.2    Ford, I.3
  • 76
    • 34247605492 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
    • Targher G, Bertolini L, Padovani R, et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 2007;30:1212-121
    • (2007) Diabetes Care , vol.30 , pp. 1212-1218
    • Targher, G.1    Bertolini, L.2    Padovani, R.3
  • 77
    • 11244308124 scopus 로고    scopus 로고
    • Chronological development of elevated aminotransferases in a nonalcoholic population
    • Suzuki A, Angulo P, Lymp J, et al. Chronological development of elevated aminotransferases in a nonalcoholic population. Hepatology 2005;41:64-71
    • (2005) Hepatology , vol.41 , pp. 64-71
    • Suzuki, A.1    Angulo, P.2    Lymp, J.3
  • 78
    • 84857422984 scopus 로고    scopus 로고
    • Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: A longitudinal study
    • Giannini C, Weiss R, Cali A, et al. Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: a longitudinal study. Diabetes 2012;61:606-614
    • (2012) Diabetes , vol.61 , pp. 606-614
    • Giannini, C.1    Weiss, R.2    Cali, A.3
  • 79
    • 33745302884 scopus 로고    scopus 로고
    • The natural course of beta-cell function in nondiabetic and diabetic individuals: The Insulin Resistance Atherosclerosis Study
    • Festa A, Williams K, D'Agostino R Jr, Wagenknecht LE, Haffner SM. The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study. Diabetes 2006;55:1114-1120
    • (2006) Diabetes , vol.55 , pp. 1114-1120
    • Festa, A.1    Williams, K.2    D'Agostino Jr., R.3    Wagenknecht, L.E.4    Haffner, S.M.5
  • 80
    • 67649111182 scopus 로고    scopus 로고
    • Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: An analysis from the Whitehall II study
    • Tabák AG, Jokela M, Akbaraly TN, Brunner EJ, Kivimäki M, Witte DR. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet 2009;373: 2215-2221
    • (2009) Lancet , vol.373 , pp. 2215-2221
    • Tabák, A.G.1    Jokela, M.2    Akbaraly, T.N.3    Brunner, E.J.4    Kivimäki, M.5    Witte, D.R.6
  • 81
    • 4644337374 scopus 로고    scopus 로고
    • Elevations in markers of liver injury and risk of type 2 diabetes: The insulin resistance atherosclerosis study
    • Insulin Resistance Atherosclerosis Study
    • Hanley AJ, Williams K, Festa A, et al.; Insulin Resistance Atherosclerosis Study. Elevations in markers of liver injury and risk of type 2 diabetes: the Insulin Resistance Atherosclerosis Study. Diabetes 2004;53:2623-2632
    • (2004) Diabetes , vol.53 , pp. 2623-2632
    • Hanley, A.J.1    Williams, K.2    Festa, A.3
  • 82
    • 0023838643 scopus 로고
    • Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment
    • Rudenski AS, Hadden DR, Atkinson AB, et al. Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment. Diabet Med 1988;5: 36-41
    • (1988) Diabet Med , vol.5 , pp. 36-41
    • Rudenski, A.S.1    Hadden, D.R.2    Atkinson, A.B.3
  • 83
    • 0031972156 scopus 로고    scopus 로고
    • UKPDS 26: Sulphonylurea failure in non-insulindependent diabetic patients over six years
    • UK Prospective Diabetes Study (UKPDS) Group
    • Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC; UK Prospective Diabetes Study (UKPDS) Group. UKPDS 26: Sulphonylurea failure in non-insulindependent diabetic patients over six years. Diabet Med 1998;15:297-303
    • (1998) Diabet Med , vol.15 , pp. 297-303
    • Matthews, D.R.1    Cull, C.A.2    Stratton, I.M.3    Holman, R.R.4    Turner, R.C.5
  • 84
    • 34147101886 scopus 로고    scopus 로고
    • Betacell function in severely obese type 2 diabetic patients: Long-term effects of bariatric surgery
    • Camastra S, Manco M, Mari A, et al. Betacell function in severely obese type 2 diabetic patients: long-term effects of bariatric surgery. Diabetes Care 2007;30: 1002-1004
    • (2007) Diabetes Care , vol.30 , pp. 1002-1004
    • Camastra, S.1    Manco, M.2    Mari, A.3
  • 85
    • 33644827082 scopus 로고    scopus 로고
    • Overproduction of large VLDL particles is driven by increased liver fat content in man
    • Adiels M, Taskinen MR, Packard C, et al. Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia 2006;49:755-765
    • (2006) Diabetologia , vol.49 , pp. 755-765
    • Adiels, M.1    Taskinen, M.R.2    Packard, C.3
  • 86
    • 10844295087 scopus 로고    scopus 로고
    • Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
    • Swedish Obese Subjects Study Scientific Group
    • Sjöström L, Lindroos AK, Peltonen M, et al.; Swedish Obese Subjects Study Scientific Group. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 2004;351: 2683-2693
    • (2004) N Engl J Med , vol.351 , pp. 2683-2693
    • Sjöström, L.1    Lindroos, A.K.2    Peltonen, M.3
  • 88
    • 84874126045 scopus 로고    scopus 로고
    • Population response to information on reversibility of type 2 diabetes
    • 15 January [Epub ahead of print]]
    • Steven S, Lim EL, Taylor R. Population response to information on reversibility of type 2 diabetes. Diabet Med. 15 January 2013 [Epub ahead of print]]
    • (2013) Diabet Med.
    • Steven, S.1    Lim, E.L.2    Taylor, R.3
  • 89
    • 84858273254 scopus 로고    scopus 로고
    • Genetic predictors of weight loss and weight regain after intensive lifestyle modification metformin treatment or standard care in the diabetes prevention program
    • Diabetes Prevention Program Research Group
    • Delahanty LM, Pan Q, Jablonski KA, et al.; Diabetes Prevention Program Research Group. Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care 2012;35:363-366
    • (2012) Diabetes Care , vol.35 , pp. 363-366
    • Delahanty, L.M.1    Pan, Q.2    Jablonski, K.A.3
  • 90
    • 0000025241 scopus 로고
    • Influence of the World War II food shortage on the incidence of diabetes mellitus in Japan
    • Goto Y, Nakayama Y, Yagi T. Influence of the World War II food shortage on the incidence of diabetes mellitus in Japan. Diabetes 1958;7:133-135
    • (1958) Diabetes , vol.7 , pp. 133-135
    • Goto, Y.1    Nakayama, Y.2    Yagi, T.3
  • 93
    • 79951692012 scopus 로고    scopus 로고
    • Exercise and type 2 diabetes: The American college of sports medicine and the American Diabetes Association: Joint position statement
    • American College of Sports Medicine; American Diabetes Association
    • Colberg SR, Sigal RJ, Fernhall B, et al.; American College of Sports Medicine; American Diabetes Association. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care 2010;33:e147-e1677
    • (2010) Diabetes Care , vol.33
    • Colberg, S.R.1    Sigal, R.J.2    Fernhall, B.3
  • 94
    • 34547177349 scopus 로고    scopus 로고
    • Metabolic and behavioral compensatory responses to exercise interventions: Barriers to weight loss
    • King NA, Caudwell P, Hopkins M, et al. Metabolic and behavioral compensatory responses to exercise interventions: barriers to weight loss.Obesity (Silver Spring) 2007; 15:1373-1383
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 1373-1383
    • King, N.A.1    Caudwell, P.2    Hopkins, M.3
  • 95
    • 80051545931 scopus 로고    scopus 로고
    • Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
    • Hallsworth K, Fattakhova G, Hollingsworth KG, et al. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut 2011;60:1278-1283
    • (2011) Gut , vol.60 , pp. 1278-1283
    • Hallsworth, K.1    Fattakhova, G.2    Hollingsworth, K.G.3
  • 96
    • 23844459275 scopus 로고    scopus 로고
    • Long-termweight loss maintenance
    • Wing RR, Phelan S. Long-termweight loss maintenance. Am J Clin Nutr 2005;82 (Suppl.):222S-225S
    • (2005) Am J Clin Nutr , vol.82 , Issue.SUPPL.
    • Wing, R.R.1    Phelan, S.2
  • 97
    • 43449108812 scopus 로고    scopus 로고
    • Economic costs of diabetes in the U.S. in 2007
    • American Diabetes Association
    • American Diabetes Association. Economic costs of diabetes in the U.S. in 2007. Diabetes Care 2008;31:596-615
    • (2008) Diabetes Care , vol.31 , pp. 596-615
  • 98
    • 51249107750 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Tracing the reverse route from cure to cause
    • Taylor R. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia 2008;51:1781-1789
    • (2008) Diabetologia , vol.51 , pp. 1781-1789
    • Taylor, R.1
  • 99
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 2012;148:852-871
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2


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