Insulin clearance and the incidence of type 2 diabetes in hispanics and African Americans: The IRAS family study

Diabetes Care

Volumn 36, Issue 4, 2013, Pages 901-907

  Lee, C Christine ^a   Haffner, Steven M ^b   Wagenknecht, Lynne E ^c   Lorenzo, Carlos ^d   Norris, Jill M ^e   Bergman, Richard N ^f   Stefanovski, Darko ^f   Anderson, Andrea M ^c   Rotter, Jerome I ^f   Goodarzi, Mark O ^f   Hanley, Anthony J ^a,g,h  

^a UNIVERSITY OF TORONTO   (Canada)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e Department of Civil and Environmental Engineering at Colorado State University and the Department of Environmental and Occupational Health at the Colorado School of Public Health   (United States)

^f CEDARS SINAI MEDICAL CENTER   (United States)

^g UNIVERSITY OF TORONTO   (Canada)

^h MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN;

ADULT; AFRICAN AMERICAN; ARTICLE; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HISPANIC; HUMAN; INCIDENCE; INSULIN BLOOD LEVEL; INSULIN CLEARANCE; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; INTRAVENOUS GLUCOSE TOLERANCE TEST; LIFESTYLE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; SUBCUTANEOUS FAT;

ADULT; AFRICAN AMERICANS; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE TOLERANCE TEST; HISPANIC AMERICANS; HUMANS; INCIDENCE; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED;

EID: 84875436576     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-1316     Document Type: Article

References (40)

1. Duckworth WC, Bennett RG, Hamel FG. The significance of intracellular insulin to insulin action. J Investig Med 1997;45: 20-27
2. Duckworth WC, Bennett RG, Hamel FG. Insulin degradation: progress and potential. Endocr Rev 1998;19:608-624
3. Bonora E, Zavaroni I, Coscelli C, Butturini U. Decreased hepatic insulin extraction in subjects with mild glucose intolerance. Metabolism 1983;32:438-446
4. Meistas MT, Margolis S, Kowarski AA. Hyperinsulinemia of obesity is due to decreased clearance of insulin. Am J Physiol 1983;245:E155-E159
5. Peiris AN, Mueller RA, Smith GA, Struve MF, Kissebah AH. Splanchnic insulin metabolism in obesity. Influence of body fat distribution. J Clin Invest 1986;78:1648-1657
6. Salvatore T, Cozzolino D, Giunta R, Giugliano D, Torella R, D'Onofrio F. Decreased insulin clearance as a feature of essential hypertension. J Clin Endocrinol Metab 1992;74:144-149
7. Iwasaki Y, Ohkubo A, Kajinuma H, Akanuma Y, Kosaka K. Degradation and secretion of insulin in hepatic cirrhosis. J Clin Endocrinol Metab 1978;47:774-779
8. Goto T, Onuma T, Takebe K, Kral JG. The influence of fatty liver on insulin clearance and insulin resistance in non-diabetic Japanese subjects. Int J Obes Relat Metab Disord 1995;19:841-845
9. Flier JS, Minaker KL, Landsberg L, Young JB, Pallotta J, Rowe JW. Impaired in vivo insulin clearance in patients with severe target-cell resistance to insulin. Diabetes 1982;31:132-135
10. Jones CN, Abbasi F, Carantoni M, Polonsky KS, Reaven GM. Roles of insulin resistance and obesity in regulation of plasma insulin concentrations. Am J Physiol Endocrinol Metab 2000;278:E501-E508
11. Haffner SM, Stern MP, Watanabe RM, Bergman RN. Relationship of insulin clearance and secretion to insulin sensitivity in non-diabetic Mexican Americans. Eur J Clin Invest 1992;22:147-153
12. Højlund K, Wojtaszewski JF, Birk J, Hansen BF, Vestergaard H, Beck-Nielsen H. Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene. Diabetologia 2006;49: 1827-1837
13. Mittelman SD, Van Citters GW, Kim SP, et al. Longitudinal compensation for fatinduced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes 2000;49: 2116-2125
14. Kim SP, Ellmerer M, Kirkman EL, Bergman RN. Beta-cell "rest" accompanies reduced first-pass hepatic insulin extraction in the insulin-resistant, fat-fed canine model. Am J Physiol Endocrinol Metab 2007;292:E1581-E15899
15. Goodarzi MO, Taylor KD, Guo X, et al. Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes 2005;54:1222-1227
16. Henkin L, Bergman RN, Bowden DW, et al. Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods. Ann Epidemiol 2003;13:211-217
17. Hanley AJ, Wagenknecht LE, Norris JM, et al. Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family study. Diabetologia 2009;52: 2079-2086
18. Herbert V, Lau KS, Gottlieb CW, Bleicher SJ. Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 1965;25: 1375-1384
19. Wagenknecht LE, Palmer ND, Bowden DW, et al. Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study. Liver Int 2011;31:412-416
20. Wagenknecht LE, Langefeld CD, Scherzinger AL, et al. Insulin sensitivity, insulin secretion, and abdominal fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes 2003;52: 2490-2496
21. Hairston KG, Vitolins MZ, Norris JM, Anderson AM, Hanley AJ, Wagenknecht LE. Lifestyle factors and 5-year abdominal fat accumulation in a minority cohort: the IRAS Family Study. Obesity (Silver Spring) 2012;20:421-427
22. Bergman RN, Finegood DT, Ader M. Assessment of insulin sensitivity in vivo. Endocr Rev 1985;6:45-86
23. Welch S, Gebhart SSP, Bergman RN, Phillips LS. Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab 1990;71: 1508-1518
24. Steil GM, Volund A, Kahn SE, Bergman RN. Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies. Diabetes 1993;42:250-256
25. Pacini G, Bergman RN. MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed 1986;23:113-122
26. Polonsky KS, Pugh W, Jaspan JB, et al. C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog. J Clin Invest 1984;74:1821-1829
27. Polonsky KS, Given BD, Hirsch L, et al. Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest 1988;81:435-441
28. Rossell R, Gomis R, Casamitjana R, Segura R, Vilardell E, Rivera F. Reduced hepatic insulin extraction in obesity: relationship with plasma insulin levels. J Clin Endocrinol Metab 1983;56:608-611
29. Faber OK, Christensen K, Kehlet H, Madsbad S, Binder C. Decreased insulin removal contributes to hyperinsulinemia in obesity. J Clin Endocrinol Metab 1981; 53:618-621
30. Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage andmobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 2002;23: 201-229
31. Wiesenthal SR, Sandhu H, McCall RH, et al. Free fatty acids impair hepatic insulin extraction in vivo.Diabetes 1999;48: 766-774
32. Yoshii H, Lam TK, Gupta N, et al. Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux. Am J Physiol Endocrinol Metab 2006; 290:E1089-E10977
33. Balent B, Goswami G, Goodloe G, et al. Acute elevation of NEFA causes hyperinsulinemia without effect on insulin secretion rate in healthy human subjects. Ann N Y Acad Sci 2002;967:535-543
34. Chinetti G, Lestavel S, Bocher V, et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 2001;7:53-58
35. Tschritter O, Fritsche A, Stefan N, et al. Increased insulin clearance in peroxisome proliferator-activated receptor gamma2 Pro12Ala. Metabolism 2003;52:778-783
36. Goodarzi MO, Cui J, Chen YD, Hsueh WA, Guo X, Rotter JI. Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. Am J Physiol Endocrinol Metab 2011;301: E402-E408
37. Kotronen A, Juurinen L, Tiikkainen M, Vehkavaara S, Yki-Järvinen H. Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroenterology 2008;135:122-130
38. Osei K, Schuster DP. Ethnic differences in secretion, sensitivity, and hepatic extraction of insulin in black and white Americans. Diabet Med 1994;11:755-762
39. Weiss R, Dziura JD, Burgert TS, Taksali SE, Tamborlane WV, Caprio S. Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents. Diabetologia 2006;49:571-579
40. Goran MI. Ethnic-specific pathways to obesity-related disease: the Hispanic vs. African-American paradox. Obesity (Silver Spring) 2008;16:2561-256