Antioxidant effect of mangiferin and its potential to be a cancer chemoprevention agent

Letters in Drug Design and Discovery

Volumn 10, Issue 3, 2013, Pages 239-244

  Zhang, Benping ^a   Fang, Jun ^a   Chen, Yan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antioxidant; Cancer chemoprevention; Carcinogenesis; DNA damage; Mangiferin; ROS.

Indexed keywords

GROWTH FACTOR; GROWTH FACTOR RECEPTOR; MANGIFERIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RAS PROTEIN; TRANSCRIPTION FACTOR;

ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL PROLIFERATION; CHEMOPROPHYLAXIS; DNA DAMAGE; DRUG MECHANISM; HUMAN; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 84875414481     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/157018013804999708     Document Type: Article

References (62)

1. Rajendran, P.; Ekambaram, G.; Magesh, V. and Sakthisekaran, D. Chemopreventive efficacy of mangiferin against benzo(a)pyrene induced lung carcinogenesis in experimental animals. Environ. Toxicol. Pharmacol., 2008, 26(3), 278-282.
2. Noah-Vanhoucke, J.; Green, L. E.; Dinh, T. A.; Alperin, P. and Smith, R. A. Cost-effectiveness of chemoprevention of breast cancer using tamoxifen in a postmenopausal US population. Cancer, 2011, 117(15), 3322-3331.
3. Andriole, G. L.; Bostwick, D. G.; Brawley, O. W.; Gomella, L. G.; Marberger, M.; Montorsi, F.; Pettaway, C. A.; Tammela, T. L.; Teloken, C.; Tindall, D. J.; Somerville, M. C.; Wilson, T. H.; Fowler, I. L. and Rittmaster, R. S. Effect of dutasteride on the risk of prostate cancer. N. Engl. J. Med., 2010, 362(13), 1192-1202.
4. Goss, P. E.; Ingle, J. N.; Ales-Martinez, J. E.; Cheung, A. M.; Chlebowski, R. T.; Wactawski-Wende, J.; McTiernan, A.; Robbins, J.; Johnson, K. C.; Martin, L. W.; Winquist, E.; Sarto, G. E.; Garber, J. E.; Fabian, C. J.; Pujol, P.; Maunsell, E.; Farmer, P.; Gelmon, K. A.; Tu, D. and Richardson, H. Exemestane for breastcancer prevention in postmenopausal women. N. Engl. J. Med., 2011, 364(25), 2381-2391.
5. Finn, O. J. and Edwards, R. P. Human papillomavirus vaccine for cancer prevention. N. Engl. J. Med., 2009, 361(19), 1899-1901.
6. Rajendran, P.; Ekambaram, G. and Sakthisekaran, D. Protective role of mangiferin against Benzo(a)pyrene induced lung carcinogenesis in experimental animals. Biol. Pharm. Bull., 2008, 31(6), 1053-1058.
7. Yoshimi, N.; Matsunaga, K.; Katayama, M.; Yamada, Y.; Kuno, T.; Qiao, Z.; Hara, A.; Yamahara, J. and Mori, H. The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats. Cancer Lett., 2001, 163(2), 163-170.
8. Muruganandan, S.; Gupta, S.; Kataria, M.; Lal, J. and Gupta, P. K. Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats. Toxicology, 2002, 176(3), 165-173.
9. Jagetia, G. C. and Venkatesha, V. A. Mangiferin protects human peripheral blood lymphocytes against γ-radiation-induced DNA strand breaks: a fluorescence analysis of DNA unwinding assay. Nutrition Research, 2006, 26(6), 303-311.
10. Jagetia, G. C. and Baliga, M. S. Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study. Phytomedicine, 2005, 12(3), 209-215.
11. Fenn, W. O.; Gerschman, R.; Gilbert, D. L.; Terwilliger, D. E. and Cothran, F. V. Mutagenic Effects of High Oxygen Tensions on Escherichia Coli. Proc. Natl. Acad. Sci. U. S. A., 1957, 43(12), 1027-1032.
12. Kessel, M.; Liu, S. X.; Xu, A.; Santella, R. and Hei, T. K. Arsenic induces oxidative DNA damage in mammalian cells. Mol. Cell Biochem., 2002, 234-235(1-2), 301-308.
13. Xu, A.; Wu, L. J.; Santella, R. M. and Hei, T. K. Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells. Cancer Res., 1999, 59(23), 5922-5926.
14. Murata-Kamiya, N.; Kamiya, H.; Kaji, H. and Kasai, H. Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells. Nucleic. Acids Res., 1997, 25(10), 1897-1902.
15. Sahu, S. C. and Gray, G. C. Lipid peroxidation and DNA damage induced by morin and naringenin in isolated rat liver nuclei. Food Chem. Toxicol., 1997, 35(5), 443-447.
16. Devi, G. S.; Prasad, M. H.; Saraswathi, I.; Raghu, D.; Rao, D. N. and Reddy, P. P. Free radicals antioxidant enzymes and lipid peroxidation in different types of leukemias. Clin. Chim. Acta, 2000, 293(1-2), 53-62.
17. Drevs, J.; Medinger, M.; Schmidt-Gersbach, C.; Weber, R. and Unger, C. Receptor tyrosine kinases: the main targets for new anticancer therapy. Curr. Drug Targets, 2003, 4(2), 113-121.
18. Faux, S. P.; Houghton, C. E.; Hubbard, A. and Patrick, G. Increased expression of epidermal growth factor receptor in rat pleural mesothelial cells correlates with carcinogenicity of mineral fibres. Carcinogenesis, 2000, 21(12), 2275-2280.
19. Herbst, R. S. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys, 2004, 59(2 Suppl), 21-26.
20. Wells, A. EGF receptor. Int. J. Biochem. Cell Biol., 1999, 31(6), 637-643.
21. Ke, L. D.; Adler-Storthz, K.; Clayman, G. L.; Yung, A. W. and Chen, Z. Differential expression of epidermal growth factor receptor in human head and neck cancers. Head Neck, 1998, 20(4), 320-327.
22. Heldin, C. H. and Westermark, B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev., 1999, 79(4), 1283-1316.
23. Campbell, J. S.; Johnson, M. M.; Bauer, R. L.; Hudkins, K. L.; Gilbertson, D. G.; Riehle, K. J.; Yeh, M. M.; Alpers, C. E. and Fausto, N. Targeting stromal cells for the treatment of plateletderived growth factor C-induced hepatocellular carcinogenesis. Differentiation, 2007, 75(9), 843-852.
24. Adams, J. M. and Cory, S. Transgenic models of tumor development. Science, 1991, 254(5035), 1161-1167.
25. Kamiya, H.; Miura, K.; Ishikawa, H.; Inoue, H.; Nishimura, S. and Ohtsuka, E. c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions. Cancer Res., 1992, 52(12), 3483-3485.
26. Adjei, A. A. Blocking oncogenic Ras signaling for cancer therapy. J. Natl. Cancer Inst., 2001, 93(14), 1062-1074.
27. Nichols, K. E.; Malkin, D.; Garber, J. E.; Fraumeni, J. F., Jr. and Li, F. P. Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers. Cancer Epidemiol Biomarkers Prev., 2001, 10(2), 83-87.
28. Park, J. H.; Gelhaus, S.; Vedantam, S.; Oliva, A. L.; Batra, A.; Blair, I. A.; Troxel, A. B.; Field, J. and Penning, T. M. The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxodGuo formation while the spectrum of mutations is determined by biological selection for dominance. Chem. Res. Toxicol., 2008, 21(5), 1039-1049.
29. Akhand, A. A.; Kato, M.; Suzuki, H.; Liu, W.; Du, J.; Hamaguchi, M.; Miyata, T.; Kurokawa, K. and Nakashima, I. Carbonyl compounds cross-link cellular proteins and activate proteintyrosine kinase p60c-Src. J. Cell Biochem., 1999, 72(1), 1-7.
30. Suzaki, Y.; Yoshizumi, M.; Kagami, S.; Koyama, A. H.; Taketani, Y.; Houchi, H.; Tsuchiya, K.; Takeda, E. and Tamaki, T. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. J. Biol. Chem., 2002, 277(11), 9614-9621.
31. Luttrell, D. K.; Lee, A.; Lansing, T. J.; Crosby, R. M.; Jung, K. D.; Willard, D.; Luther, M.; Rodriguez, M.; Berman, J. and Gilmer, T. M. Involvement of pp60c-src with two major signaling pathways in human breast cancer. Proc. Natl. Acad. Sci. U. S.A., 1994, 91(1), 83-87.
32. Licato, L. L. and Brenner, D. A. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Dig. Dis. Sci., 1998, 43(7), 1454-1464.
33. Lutz, M. P.; Esser, I. B.; Flossmann-Kast, B. B.; Vogelmann, R.; Luhrs, H.; Friess, H.; Buchler, M. W. and Adler, G. Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma. Biochem. Biophys. Res. Commun., 1998, 243(2), 503-508.
34. Rosen, N.; Bolen, J. B.; Schwartz, A. M.; Cohen, P.; DeSeau, V. and Israel, M. A. Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues. J. Biol. Chem., 1986, 261(29), 13754-13759.
35. Wiener, J. R.; Windham, T. C.; Estrella, V. C.; Parikh, N. U.; Thall, P. F.; Deavers, M. T.; Bast, R. C.; Mills, G. B. and Gallick, G. E. Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers. Gynecol. Oncol., 2003, 88(1), 73-79.
36. Bang, Y. J.; Kwon, J. H.; Kang, S. H.; Kim, J. W. and Yang, Y. C. Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma. Biochem. Biophys. Res. Commun., 1998, 250(1), 43-47.
37. Roy, H. K.; Olusola, B. F.; Clemens, D. L.; Karolski, W. J.; Ratashak, A.; Lynch, H. T. and Smyrk, T. C. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis, 2002, 23(1), 201-205.
38. Sand, J. M.; Aziz, M. H.; Dreckschmidt, N. E.; Havighurst, T. C.; Kim, K.; Oberley, T. D. and Verma, A. K. PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas. J. Inves.t Dermatol., 2010, 130(1), 270-277.
39. Valko, M.; Rhodes, C. J.; Moncol, J.; Izakovic, M. and Mazur, M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact., 2006, 160(1), 1-40.
40. Maziere, C.; Conte, M. A.; Degonville, J.; Ali, D. and Maziere, J. C. Cellular enrichment with polyunsaturated fatty acids induces an oxidative stress and activates the transcription factors AP1 and NFkappaB. Biochem. Biophys. Res. Commun., 1999, 265(1), 116-122.
41. Rorke, E. A.; Adhikary, G.; Jans, R.; Crish, J. F. and Eckert, R. L. AP1 factor inactivation in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen-dependent tumor formation. Oncogene, 2010, 29(44), 5873-5882.
42. Karin, M. and Greten, F. R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol., 2005, 5(10), 749-759.
43. Zhong, H.; De Marzo, A. M.; Laughner, E.; Lim, M.; Hilton, D. A.; Zagzag, D.; Buechler, P.; Isaacs, W. B.; Semenza, G. L. and Simons, J. W. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res., 1999, 59(22), 5830-5835.
44. Chen, C. L.; Chu, J. S.; Su, W. C.; Huang, S. C. and Lee, W. Y. Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX. Virchows Arch., 2010, 457(1), 53-61.
45. Bonello, S.; Zahringer, C.; BelAiba, R. S.; Djordjevic, T.; Hess, J.; Michiels, C.; Kietzmann, T. and Gorlach, A. Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site. Arterioscler. Thromb. Vasc. Biol., 2007, 27(4), 755-761.
46. Huang, C.; Li, J.; Costa, M.; Zhang, Z.; Leonard, S. S.; Castranova, V.; Vallyathan, V.; Ju, G. and Shi, X. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Cancer Res., 2001, 61(22), 8051-8057.
47. Viola, J. P.; Carvalho, L. D.; Fonseca, B. P. and Teixeira, L. K. NFAT transcription factors: from cell cycle to tumor development. Braz. J. Med. Biol. Res., 2005, 38(3), 335-344.
48. Dizdaroglu, M.; Jaruga, P.; Birincioglu, M. and Rodriguez, H. Free radical-induced damage to DNA: mechanisms and measurement. Free Radic. Biol. Med., 2002, 32(11), 1102-1115.
49. Helbock, H. J.; Beckman, K. B.; Shigenaga, M. K.; Walter, P. B.; Woodall, A. A.; Yeo, H. C. and Ames, B. N. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxodeoxyguanosine and 8-oxo-guanine. Proc. Natl. Acad. Sci. U. S. A., 1998, 95(1), 288-293.
50. Marnett, L. J. Oxyradicals and DNA damage. Carcinogenesis, 2000, 21(3), 361-370.
51. Shamberger, R. J.; Andreone, T. L. and Willis, C. E. Antioxidants and cancer. IV. Initiating activity of malonaldehyde as a carcinogen. J. Natl. Cancer Inst., 1974, 53(6), 1771-1773.
52. Voitkun, V. and Zhitkovich, A. Analysis of DNA-protein crosslinking activity of malondialdehyde in vitro. Mutat. Res., 1999, 424(1-2), 97-106.
53. VanderVeen, L. A.; Hashim, M. F.; Shyr, Y. and Marnett, L. J. Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde. Proc. Natl. Acad. Sci. U. S. A., 2003, 100(24), 14247-14252.
54. Iqbal, M.; Giri, U.; Giri, D. K.; Alam, M. S. and Athar, M. Agedependent renal accumulation of 4-hydroxy-2-nonenal (HNE)-modified proteins following parenteral administration of ferric nitrilotriacetate commensurate with its differential toxicity: implications for the involvement of HNE-protein adducts in oxidative stress and carcinogenesis. Arch. Biochem. Biophys., 1999, 365(1), 101-112.
55. Wei, Y. H.; Lu, C. Y.; Lee, H. C.; Pang, C. Y. and Ma, Y. S. Oxidative damage and mutation to mitochondrial DNA and agedependent decline of mitochondrial respiratory function. Ann. N. Y. Acad. Sci., 1998, 854, 155-170.
56. Sanchez, G. M.; Re, L.; Giuliani, A.; Nunez-Selles, A. J.; Davison, G. P. and Leon-Fernandez, O. S. Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacol. Res., 2000, 42(6), 565-573.
57. Muruganandan, S.; Lal, J. and Gupta, P. K. Immunotherapeutic effects of mangiferin mediated by the inhibition of oxidative stress to activated lymphocytes, neutrophils and macrophages. Toxicology, 2005, 215(1-2), 57-68.
58. Pardo-Andreu, G. L.; Barrios, M. F.; Curti, C.; Hernandez, I.; Merino, N.; Lemus, Y.; Martinez, I.; Riano, A. and Delgado, R. Protective effects of Mangifera indica L extract (Vimang), and its major component mangiferin, on iron-induced oxidative damage to rat serum and liver. Pharmacol. Res., 2008, 57(1), 79-86.
59. Surh, Y. J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer, 2003, 3(10), 768-780.
60. Kay, H. Y.; Won Yang, J.; Kim, T. H.; Lee da, Y.; Kang, B.; Ryu, J. H.; Jeon, R. and Kim, S. G. Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes. J. Nutr., 2010, 140(7), 1211-1219.
61. Li, J.; Johnson, D.; Calkins, M.; Wright, L.; Svendsen, C. and Johnson, J. Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. Toxicol. Sci., 2005, 83(2), 313-328.
62. Rajendran, P.; Ekambaram, G. and Sakthisekaran, D. Cytoprotective effect of mangiferin on benzo(a)pyrene-induced lung carcinogenesis in. swiss albino mice. Basic Clin. Pharmacol. Toxicol., 2008, 103(2), 137-142