Lipid peroxidation and DNA damage induced by morin and naringenin in isolated rat liver nuclei

Food and Chemical Toxicology

Volumn 35, Issue 5, 1997, Pages 443-447

  Sahu, S C ^a   Gray, G C ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; COPPER; FLAVONOID; IRON; MANNITOL; MORIN; NARINGENIN; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; LIPID PEROXIDATION; LIVER CELL NUCLEUS; MALE; NONHUMAN;

ANIMALS; ANTIOXIDANTS; CELL NUCLEUS; COPPER; DNA DAMAGE; DNA REPAIR; FLAVANONES; FLAVONOIDS; FREE RADICAL SCAVENGERS; IRON; LIPID PEROXIDATION; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030977542     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(97)00011-2     Document Type: Article

References (29)

1. Ames B. N. (1983) Dietary carcinogens and anticarcinogens. Science 221, 1256-1264.
2. Ames B. N. (1989) Endogenous oxidative DNA damage, ageing and cancer. Free Radical Research Communications 7, 121-128.
3. Birnboim H. C. (1990) Fluorometric analysis of DNA unwinding to study strand breaks and repair in mammalian cells. Methods in Enzymology 186, 550-555.
4. Brown J. P. (1980) A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. Mutation Research 75, 243-277.
5. Buege J. A. and Aust S. D. (1978) Microsomal lipid peroxidation. Methods in Enzymology 52, 302-310.
6. Cerutti P. A. (1985) Pro-oxidant states and tumour promotion. Science 227, 375-380.
7. Dische Z. (1955) Colour reactions of nucleic acid components. In The Nucleic Acids: Chemistry and Biology. Vol. 1. Edited by E. Chargaff and J. N. Davidson. pp. 285-305. Academic Press, New York.
8. Dunnick J. K. and Hailey J. R. (1992) Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundamental and Applied Toxicology 19, 423-431.
9. Erturk E., Hatcher J. F., Nunoya T., Pamukcu A. M. and Bryan G. T. (1984) Hepatic tumours in Sprague-Dawley and Fischer-344 female rats exposed chronically to quercetin or its glycoside rutin. (Abstract). Cancer Research 25, 95.
10. Fiala E. S., Reddy B. S. and Weisberger J. H. (1985) Naturally occurring anticarcinogenic substances in food. Annual Review of Nutrition 5, 295-321.
11. Franke W. W., Scheer U., Krohne G. and Jarasch E. (1981) The nuclear envelope and the architecture of the nuclear periphery. Journal of Cell Biology 91, 39S-50S.
12. 1 activation in human liver microsomes by flavonoids. Carcinogenesis 11, 2275-2279.
13. Herrmann K. (1976) Flanonols and flavones in food plants: a review. Journal of Food Technology 11, 433-448.
14. Hertog M. G. L., Hollman P. C. H., Katan M. B. and Kromhout D. (1993) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutrition and Cancer 20, 21-29.
15. Hirono I., Ueno I., Hosaka S., Takanashi H., Matsushima T., Sugimura T. and Natori S. (1981) Carcinogenicity examination of quercetin and rutin in ACI rats. Cancer Letters 13, 15-21.
16. Hodnick W. F., Kung F. S., Roettger W. J., Bohmont C. W. and Pardini R. S. (1986) Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. Biochemical Pharmacology 35, 2345-2357.
17. Ito N., Hagiwara A., Tamano S., Kagawa M., Shibata M., Kurata Y. and Fukushima S. (1989) Lack of carcinogenicity of quercetin in F344/DuCrj rats. Japanese Journal of Cancer Research 80, 317-325.
18. Kahl R. (1986) The dual role of antioxidants in the modification of chemical carcinogenesis. Journal of Environmental Science and Health C4 (1), 47-92.
19. Nagao M., Morita N., Yahagi T. and Sugimura T. (1981) Mutagenicities of 61 flavonoids and 11 related compounds. Environmental Mutagenesis 3, 401-419.
20. NTP (1991) NTP Technical Report (No. 409) on the Toxicology and Carcinogenesis Studies on Quercetin in F344/N Rats. NIH Publication No. 91-3140. US Department of Health and Human Services, Toxicology Program, Research Triangle Park, NC.
21. Ochiai M., Nagoo M., Wakabayashi K. and Sugimura T. (1984) Superoxide dismutase acts as enhancing factor for quercetin mutagenicity in rat liver cytosol by preventing its decomposition. Mutation Research 129, 19-24.
22. Pamukcu A. M., Yalciner S., Hatcher J. F. and Bryan G. T. (1980) Quercetin, a rat intestinal and bladder carcinogen, present in bracken fern. Cancer Research 40, 3468-3472.
23. Sahu S. C. (1991) Role of oxygen free radicals in the molecular mechanisms of carcinogenesis: a review. Journal of Environmental Science and Health C9, 83-112.
24. Sahu S. C. (1994) Dual role of flavonoids in mutagenesis and carcinogenesis. Journal of Environmental Science and Health C12, 1-21.
25. Sahu S. C. and Gray G. C. (1994) Kaempferol-induced DNA damage and lipid peroxidation. Cancer Letters 85, 159-164.
26. Sahu S. C. and Gray G. C. (1996) Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-transferase in isolated rat liver nuclei. Cancer Letters 104, 193-196.
27. Sahu S. C. and Washington M. C. (1991) Quercetin-induced lipid peroxidation and DNA damage in isolated rat liver nuclei. Cancer Letters 58, 75-79.
28. Taningher M., Bordone R., Russo P., Grilli S., Santi L. and Parodi S. (1987) Major discrepancies between results obtained with two different methods for evaluating DNA damage: alkaline elution and alkaline unwinding. Anticancer Research 7, 669-680.
29. Zhu B. T. and Liehr J. G. (1994) Quercetin increases the severity of estradiol-induced tumorigenesis in hamster kidney. Toxicology and Applied Pharmacology 125, 149-158.