Functional dissection of toxoplasma gondii perforin-like protein 1 reveals a dual domain mode of membrane binding for cytolysis and parasite egress

Journal of Biological Chemistry

Volumn 288, Issue 12, 2013, Pages 8712-8725

  Roiko, Marijo S ^a,b   Carruthers, Vern B ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL DOMAINS; FUNCTIONAL DIVERSITY; GENETIC COMPLEMENTATION; MEMBRANE ASSOCIATION; MEMBRANE DISRUPTION; N-TERMINAL EXTENSION; PORE-FORMING PROTEINS; PROTOZOAN PARASITES;

DISSECTION; OLIGOMERIZATION; OLIGOMERS; PLANTS (BOTANY); PORE SIZE; PROTEINS;

MEMBRANES;

MICROORGANISM PROTEIN; PERFORIN LIKE PROTEIN 1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOLYSIS; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; MEMBRANE BINDING; MEMBRANE DAMAGE; NONHUMAN; OLIGOMERIZATION; PARASITE VIRULENCE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN FUNCTION; TOXOPLASMA GONDII;

ANIMALS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; ERYTHROCYTES; FEMALE; GENE KNOCKOUT TECHNIQUES; HEMOLYSIS; HOST-PARASITE INTERACTIONS; HUMANS; MICE; PERFORIN; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; SEQUENCE DELETION; TOXOPLASMA; TOXOPLASMOSIS;

PROTOZOA; TOXOPLASMA GONDII;

EID: 84875414130     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.450932     Document Type: Article

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