Clinicopathological and prognostic significance of HIF-1α and HIF-2α expression in small cell lung cancer

Pathology Research and Practice

Volumn 209, Issue 3, 2013, Pages 184-189

  Luan, Yajing ^a   Gao, Cuicui ^a   Miao, Yajing ^a   Li, Yanlei ^a   Wang, Zhengyan ^a   Qiu, Xiaofei ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Clinicopathological features; HIF 1 ; HIF 2 ; Prognosis; Small cell lung cancer

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; UROKINASE RECEPTOR;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER PROGNOSIS; CANCER SIZE; CANCER SURVIVAL; CARCINOGENESIS; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISTANT METASTASIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LUNG SMALL CELL CANCER; MALE; METASTASIS POTENTIAL; OVERALL SURVIVAL; PHENOTYPE; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

ADULT; AGED; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; SMALL CELL LUNG CARCINOMA; TUMOR MARKERS, BIOLOGICAL;

EID: 84875376449     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2012.10.017     Document Type: Article

References (33)

1. Semenza G.L. Intratumoral hypoxia, radiation resistance, and HIF-1. Cancer Cell 2004, 5:405-406.
2. Chi J.T., Wang Z., Nuyten D.S.A., Rodriguez E.H., Schaner M.E., Salim A., et al. Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med. 2006, 3:395-409.
3. Rofstad E.K., Rasmussen H., Galappathi K., Mathiesen B., Nilsen K., Graff B.A. Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptors. Cancer Res. 2002, 62:1847-1853.
4. Harris A.L. Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2002, 2:38-47.
5. Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 3:721-732.
6. Huang L.E., Gu J., Schau M., Bunn H.F. Regulation of hypoxia-inducible factor 1 alpha is mediated by an O-2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:7987-7992.
7. Qiu X., et al. Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446. Cancer Lett. 2012, 10.1016/j.canlet.2012.04.004.
8. Buchler P., Reber H.A., Tomlinson J.S., Hankinson O., Kallifatidis G., Friess H., et al. Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer. Neoplasia (New York, NY) 2009, 11:196-206.
9. Graham C.H., Forsdike J., Fitzgerald C.J., Macdonald-Goodfellow S. Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression. Int. J. Cancer 1999, 80:617-623.
10. Covello K.L., Kehler J., Yu H., Gordan J.D., Arsham A.M., Hu C.J., et al. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006, 20:557-570.
11. Hu C.J., Wang L.Y., Chodosh L.A., Keith B., Simon M.C. Differential roles of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in hypoxic gene regulation. Mol. Cell. Biol. 2003, 23:9361-9374.
12. Raval R.R., Lau K.W., Tran M.G., Sowter H.M., Mandriota S.J., Li J.L., et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol. Cell. Biol. 2005, 25:5675-5686.
13. Baba M., Hirai S., Yamada-Okabe H., Hamada K., Tabuchi H., Kobayashi K., et al. Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through Hypoxia-inducible factor. Oncogene 2003, 22:2728-2738.
14. Gordan J.D., Bertout J.A., Hu C.-J., Diehl J.A., Simon M.C. HIF-2 alpha promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity. Cancer Cell 2007, 11:335-347.
15. -/- renal cell carcinoma cells. J. Biol. Chem. 2003, 278:44966-44974.
16. Gort E.H., van Haaften G., Verlaan I., Groot A.J., Plasterk R.H.A., Shvarts A., et al. The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2 alpha. Oncogene 2008, 27:1501-1510.
17. Ioannou M., Papamichali R., Kouvaras E., Mylonis I., Vageli D., Kerenidou T., et al. Hypoxia inducible factor-1alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma. Lung 2009, 187:321-329.
18. Covello K.L., Simon M.C., Keith B. Targeted replacement of hypoxia-inducible factor-1 alpha by a hypoxia-inducible factor-2 alpha knock-in allele promotes tumor growth. Cancer Res. 2005, 65:2277-2286.
19. Wang V., Davis D.A., Haque M., Huang L.E., Yarchoan R. Differential gene up-regulation by hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in HEK293T cells. Cancer Res. 2005, 65:3299-3306.
20. Acker T., Diez-Juan A., Aragones J., Tjwa M., Brusselmans K., Moons L., et al. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell 2005, 8:131-141.
21. Li Z., Bao S., Wu Q., Wang H., Eyler C., Sathornsumetee S., et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009, 15:501-513.
22. Pietras A., Gisselsson D., Ora I., Noguera R., Beckman S., Navarro S., et al. High levels of HIF-2 alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche. J. Pathol. 2008, 214:482-488.
23. Birner P., Schindl M., Obermair A., Plank C., Breitenecker G., Oberhuber G. Overexpression of hypoxia-inducible factor 1 alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 2000, 60:4693-4696.
24. Holmquist-Mengelbier L., Fredlund E., Lofstedt T., Noguera R., Navarro S., Nilsson H., et al. Recruitment of HIF-1 alpha and HIF-2 alpha to common target genes is differentially regulated in neuroblastoma: HIF-2 alpha promotes an aggressive phenotype. Cancer Cell 2006, 10:413-423.
25. Lester R.D., Jo M., Montel V., Takimoto S., Gonias S.L. uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J. Cell Biol. 2007, 178:425-436.
26. Kim W.Y., Perera S., Zhou B., Carretero J., Yeh J.J., Heathcote S.A., et al. HIF2 alpha cooperates with RAS to promote lung tumorigenesis in mice. J. Clin. Invest. 2009, 119:2160-2170.
27. Helczynska K., Larsson A.-M., Mengelbier L.H., Bridges E., Fredlund E., Borgquist S., et al. Hypoxia-inducible factor-2 alpha correlates to distant recurrence and poor outcome in invasive breast cancer. Cancer Res. 2008, 68:9212-9220.
28. Arvidsson Y., Bergstrom A., Arvidsson L., Kristiansson E., Ahlman H., Nilsson O. Hypoxia stimulates CXCR4 signalling in ileal carcinoids. Endocr. Relat. Cancer 2010, 17:303-316.
29. Vaupel P., Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007, 26:225-239.
30. Sathornsumetee S., Cao Y., Marcello J.E., Ii J.E.H., McLendon R.E., Desjardins A., et al. Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J. Clin. Oncol. 2008, 26:271-278.
31. Giatromanolaki A., Koukourakis M.I., Sivridis E., Turley H., Talks K., Pezzella F., et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br. J. Cancer 2001, 85:881-890.
32. Yoshimura H., Dhar D.K., Kohno H., Kubota H., Fujii T., Ueda S., et al. Prognostic impact of hypoxia-inducible factors 1 alpha and 2 alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin. Cancer Res. 2004, 10:8554-8560.
33. Koh M.Y., Lemos R., Liu X., Powis G. The hypoxia-associated factor switches cells from HIF-1 alpha- to HIF-2 alpha-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res. 2011, 71:4015-4027.