Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: Evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model

Current Rheumatology Reports

Volumn 15, Issue 5, 2013, Pages

  Green, Justin M ^a   Hallab, Nadim J ^b   Liao, Yen Shuo ^c   Narayan, Venkat ^c   Schwarz, Edward M ^a   Xie, Chao ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b RUSH MEDICAL COLLEGE   (United States)

^c JOHNSON AND JOHNSON   (United States)

Author keywords

Antioxidant; Mouse model; Murine model; Osteoarthritis; Osteolysis; Treatment; Ultra high molecular weight polyethylene (UHMWPE); Wear debris

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; MONOMER; REACTIVE OXYGEN METABOLITE; ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE; POLYETHYLENE DERIVATIVE; ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE;

ARTHROPLASTY; BONE DENSITY; BONE DEVELOPMENT; BONE MASS; CALVARIA; CROSS LINKING; GAMMA IRRADIATION; HYDROGEL; MECHANICAL STRESS; MICRO-COMPUTED TOMOGRAPHY; MOLECULAR WEIGHT; NONHUMAN; OSTEOLYSIS; OXIDATION; PARTICLE SIZE; PERIPROSTHETIC OSTEOLYSIS; PROSTHESIS LOOSENING; PROSTHESIS MATERIAL; REVIEW; WEAR DEBRIS; ANIMAL; ANIMAL MODEL; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; DRUG THERAPY; MOUSE; OSTEOCLAST; PILOT STUDY; PREVENTION AND CONTROL; PROSTHESIS FAILURE; RADIOGRAPHY; SKULL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT;

ANIMALS; ANTIOXIDANTS; BONE RESORPTION; DISEASE MODELS, ANIMAL; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; OSTEOCLASTS; OSTEOLYSIS; PARTICLE SIZE; PILOT PROJECTS; POLYETHYLENES; PROSTHESIS FAILURE; SKULL; X-RAY MICROTOMOGRAPHY;

EID: 84875303433     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-013-0325-3     Document Type: Review

References (33)

1. Gomez-Barrena E, Medel F, Puertolas JA. Polyethylene oxidation in total hip arthroplasty: evolution and new advances. Open Orthop J. 2009;3:115-20.
2. •• Graves SE, et al. A multinational assessment of metal-on-metal bearings in hip replacement. J Bone Joint Surg Am. 2012;93 Suppl 3:43-7. Highly cited reference describing early failure problems with metal-on-metal implants.
3. Garcia-Cimbrelo E, et al. Mittelmeier ceramic-ceramic prosthesis after 10 years. J Arthroplasty. 1996;11:773-81. (Pubitemid 26393855)
4. Jahan M, et al. A study of long-lived free radicals in gamma-irradiated medical grade polyethlene. Radiat Phys Chem. 2001;62:141-4. (Pubitemid 32823283)
5. Currier BH, et al. Shelf life and in vivo duration. Impacts on performance of tibial bearings. Clin Orthop Relat Res. 1997;342:111-22. (Pubitemid 27400810)
6. Gomez-Barrena E, et al. Role of polyethylene oxidation and consolidation defects in cup performance. Clin Orthop Relat Res. 1998;352:105-17. (Pubitemid 28326289)
7. Hallab NJ, Jacobs JJ. Biologic effects of implant debris. Bull NYU Hosp Jt Dis. 2009;67:182-8.
8. •• Atwood SA, et al. Tradeoffs amongst fatigue, wear, and oxidation resistance of cross-linked ultra-high molecular weight polyethylene. J Mech Behav Biomed Mater. 2011;4:1033-45. This is the first study to simultaneously evaluate fatigue crack propagation, wear, oxidation, and microstructure in a wide variety of clinically-relevant ultra-high molecular weight polyethylene. The trade-off we have shown in fatigue, wear, and oxidation performance is critical to the material's long-term success in total joint replacements.
9. • Kurtz SM, et al. Mechanical properties, oxidation, and clinical performance of retrieved highly cross-linked Crossfire liners after intermediate-term implantation. J Arthroplasty. 2009;25:614-23. e611-612. Highly cited reference on the properties and clinical performance of UHMWPE bearings.
10. Lidgren L, et al. The invention relates to a method for the preparation in a reactor of a UHMWPE material doped with an antioxidant, preferably vitamin E. US patent# 6448315. 2002.
11. • Oral E, Muratoglu OK. Vitamin E diffused, highly crosslinked UHMWPE: a review. Int Orthop. 2010;35:215-23. Highly cited reference on the incorporation of vitamin E into UHMWPE bearings.
12. Ingham E, Fisher J. Biological reactions to wear debris in total joint replacement. Proc Inst Mech Eng H. 2000;214:21-37. (Pubitemid 32508299)
13. Ingham E, Fisher J. The role of macrophages in osteolysis of total joint replacement. Biomaterials. 2005;26:1271-86. (Pubitemid 39314501)
14. Purdue PE, et al. The central role of wear debris in periprosthetic osteolysis. HSS J. 2006;2:102-13. (Pubitemid 44328104)
15. Merkel KD, et al. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. Am J Pathol. 1999;154:203-10. (Pubitemid 29031627)
16. Schwarz EM, et al. Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis. J Orthop Res. 2000;18:849-55. (Pubitemid 32055754)
17. von Knoch M, et al. The decrease of particle-induced osteolysis after a single dose of bisphosphonate. Biomaterials. 2005;26:1803-8. (Pubitemid 39575322)
18. Tsutsumi R, et al. Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. J Orthop Res. 2008;26:1340-6.
19. Goater JJ, et al. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. J Orthop Res. 2002;20:169-73. (Pubitemid 34218258)
20. Zhang X, et al. Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis. J Bone Miner Res. 2001;16:660-70. (Pubitemid 32230594)
21. Childs LM, et al. Efficacy of etanercept for wear debris-induced osteolysis. J Bone Miner Res. 2001;16:338-47. (Pubitemid 32105415)
22. Childs LM, et al. In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res. 2002;17:192-9. (Pubitemid 34087651)
23. Clohisy JC, et al. NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis. J Orthop Res. 2004;22:13-20. (Pubitemid 38035440)
24. Clohisy JC, et al. Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. J Orthop Res. 2006;24:1358-65. (Pubitemid 44083251)
25. Yamanaka Y, et al. Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts. J Orthop Res. 2006;24:1349-57. (Pubitemid 44083250)
26. Burton L, et al. Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation. J Orthop Res. 2012;31:73-80.
27. •• Mediero A, et al. Adenosine A2A receptor activation prevents wear particle-induced osteolysis. Sci Transl Med. 2012;4:135ra165. Novel therapeutic approach to prevent wear debris-induced osteolysis.
28. Taki N, et al. Polyethylene and titanium particles induce osteolysis by similar, lymphocyte-independent, mechanisms. J Orthop Res. 2005;23:376-83. (Pubitemid 40287864)
29. Kaar SG, et al. Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice. J Orthop Res. 2001;19:171-8. (Pubitemid 32331689)
30. Martell JM, Berdia S. Determination of polyethylene wear in total hip replacements with use of digital radiographs. J Bone Joint Surg Am. 1997;79:1635-41. (Pubitemid 27508522)
31. Looney RJ, et al. Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear. Arthritis Res. 2002;4:59-63. (Pubitemid 34100490)
32. Howie DW, et al. Progression of acetabular periprosthetic osteolytic lesions measured with computed tomography. J Bone Joint Surg Am. 2007;89:1818-25. (Pubitemid 47229891)
33. Schwarz EM, et al. Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo. J Orthop Res. 2003;21:1049-55. (Pubitemid 37322387)