Neuroimaging studies of alexithymia: Physical, affective, and social perspectives

BioPsychoSocial Medicine

Volumn 7, Issue 1, 2013, Pages

  Moriguchi, Yoshiya ^a   Komaki, Gen ^b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^b INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

Alexithymia; Emotional awareness; fMRI; Interoception; Neuroimaging study; PET; Psychosomatic medicine

Indexed keywords

EID: 84875298450     PISSN: None     EISSN: 17510759     Source Type: Journal    
DOI: 10.1186/1751-0759-7-8     Document Type: Review

References (84)

1. Sifneos PE. Short-Term Psychotherapy and Emotional Crisis 1972, Cambridge, MA: Harvard University Press.
2. Komaki G, In Somatization and Psychosomatic Symptoms Alexithymia and Psychosomatic Symptoms New York: Springer; in press: Edited by Koh KB, In Somatization and Psychosomatic Symptoms.
3. MacLean PD. Psychosomatic disease and the visceral brain; recent developments bearing on the Papez theory of emotion. Psychosom Med 1949, 11:338-353.
4. Hoppe KD, Bogen JE. Alexithymia in twelve commissurotomized patients. Psychother Psychosom 1977, 28:148-155. 10.1159/000287057, 609675.
5. Miller L. Is alexithymia a disconnection syndrome? A neuropsychological perspective. Int J Psychiatry Med 1986, 16:199-209. 10.2190/DAE0-EWPX-R7D6-LFNY, 3804583.
6. Sifneos PE. Alexithymia and its relationship to hemispheric specialization, affect, and creativity. Psychiatr Clin North Am 1988, 11:287-292.
7. Buchanan DC, Waterhouse GJ, West SC. A proposed neurophysiological basis of alexithymia. Psychother Psychosom 1980, 34:248-255. 10.1159/000287465, 7280165.
8. Shipko S. Further reflections on psychosomatic theory. Alexithymia and interhemispheric specialization. Psychotherapy and psychosomatics 1982, 37:83-86. 10.1159/000287557, 7122790.
9. Lane RD, Reiman EM, Axelrod B, Yun LS, Holmes A, Schwartz GE. Neural correlates of levels of emotional awareness Evidence of an interaction between emotion and attention in the anterior cingulate cortex. J cognitive neuroscience 1998, 10:525-535.
10. Wingbermühle E, Theunissen H, Verhoeven WMA, Kessels RPC, Egger JIM. The neurocognition of alexithymia: evidence from neuropsychological and neuroimaging studies. Acta Neuropsychiatrica 2012, 24:67-80.
11. Grynberg D, Chang B, Corneille O, Maurage P, Vermeulen N, Berthoz S, Luminet O. Alexithymia and the processing of emotional facial expressions (EFEs): systematic review, unanswered questions and further perspectives. PLoS One 2012, 7:e42429. 10.1371/journal.pone.0042429, 3426527, 22927931.
12. Kano M, Fukudo S. The alexithymic brain: the neural pathways linking alexithymia to physical disorders. BioPsychoSocial medicine 2013, 7:1. 10.1186/1751-0759-7-1, 3563604, 23302233.
13. Lane RD, Quinlan DM, Schwartz GE, Walker PA, Zeitlin SB. The Levels of Emotional Awareness Scale: a cognitive-developmental measure of emotion. J Pers Assess 1990, 55:124-134.
14. Berthoz S, Artiges E, Van De Moortele PF, Poline JB, Rouquette S, Consoli SM, Martinot JL. Effect of impaired recognition and expression of emotions on frontocingulate cortices: an fMRI study of men with alexithymia. Am J Psychiatry 2002, 159:961-967. 10.1176/appi.ajp.159.6.961, 12042184.
15. Taylor GJ, Bagby RM, Parker JD. The 20-Item Toronto Alexithymia Scale IV. Reliability and factorial validity in different languages and cultures. J psychosomatic research 2003, 55:277-283.
16. Parker JD, Taylor GJ, Bagby RM. The 20-Item Toronto Alexithymia Scale III. Reliability and factorial validity in a community population. J psychosomatic research 2003, 55:269-275.
17. Bagby RM, Taylor GJ, Parker JD. The Twenty-item Toronto Alexithymia Scale-II. Convergent, discriminant, and concurrent validity. J Psychosom Res 1994, 38:33-40. 10.1016/0022-3999(94)90006-X, 8126688.
18. Bagby RM, Parker JD, Taylor GJ. The twenty-item Toronto Alexithymia Scale-I Item selection and cross-validation of the factor structure. J psychosomatic research 1994, 38:23-32.
19. Kano M, Fukudo S, Gyoba J, Kamachi M, Tagawa M, Mochizuki H, Itoh M, Hongo M, Yanai K. Specific brain processing of facial expressions in people with alexithymia: an H2 15O-PET study. Brain: a journal of neurology 2003, 126:1474-1484.
20. Kugel H, Eichmann M, Dannlowski U, Ohrmann P, Bauer J, Arolt V, Heindel W, Suslow T. Alexithymic features and automatic amygdala reactivity to facial emotion. Neurosci Lett 2008, 435:40-44. 10.1016/j.neulet.2008.02.005, 18314269.
21. Reker M, Ohrmann P, Rauch AV, Kugel H, Bauer J, Dannlowski U, Arolt V, Heindel W, Suslow T. Individual differences in alexithymia and brain response to masked emotion faces. Cortex; a j devoted to the study of the nervous system and behavior 2010, 46:658-667. 10.1016/j.cortex.2009.05.008, 23555895.
22. Duan X, Dai Q, Gong Q, Chen H. Neural mechanism of unconscious perception of surprised facial expression. NeuroImage 2010, 52:401-407. 10.1016/j.neuroimage.2010.04.021, 20398771.
23. Pouga L, Berthoz S, de Gelder B, Grezes J. Individual differences in socioaffective skills influence the neural bases of fear processing: the case of alexithymia. Hum Brain Mapp 2010, 31:1469-1481. 10.1002/hbm.20953, 20127873.
24. Frewen PA, Lanius RA, Dozois DJ, Neufeld RW, Pain C, Hopper JW, Densmore M, Stevens TK. Clinical and neural correlates of alexithymia in posttraumatic stress disorder. J Abnorm Psychol 2008, 117:171-181.
25. Craig AD. Emotional moments across time: a possible neural basis for time perception in the anterior insula. Philos Trans R Soc Lond B Biol Sci 2009, 364:1933-1942. 10.1098/rstb.2009.0008, 2685814, 19487195.
26. Craig AD. How do you feel-now? The anterior insula and human awareness. Nat Rev Neurosci 2009, 10:59-70. 10.1038/nrn2555, 19096369.
27. Allman JM, Watson KK, Tetreault NA, Hakeem AY. Intuition and autism: a possible role for Von Economo neurons. Trends Cogn Sci 2005, 9:367-373. 10.1016/j.tics.2005.06.008, 16002323.
28. Eichmann M, Kugel H, Suslow T. Difficulty identifying feelings and automatic activation in the fusiform gyrus in response to facial emotion. Percept Mot Skills 2008, 107:915-922.
29. Lee BT, Lee HY, Park SA, Lim JY, Tae WS, Lee MS, Joe SH, Jung IK, Ham BJ. Neural substrates of affective face recognition in alexithymia: a functional magnetic resonance imaging study. Neuropsychobiology 2011, 63:119-124. 10.1159/000318086, 21196782.
30. Miyake Y, Okamoto Y, Onoda K, Shirao N, Yamawaki S. Brain activation during the perception of stressful word stimuli concerning interpersonal relationships in anorexia nervosa patients with high degrees of alexithymia in an fMRI paradigm. Psychiatry Res 2012, 201:113-119. 10.1016/j.pscychresns.2011.07.014, 22398299.
31. Heinzel A, Schafer R, Muller HW, Schieffer A, Ingenhag A, Eickhoff SB, Northoff G, Franz M, Hautzel H. Increased activation of the supragenual anterior cingulate cortex during visual emotional processing in male subjects with high degrees of alexithymia: an event-related fMRI study. Psychother Psychosom 2010, 79:363-370. 10.1159/000320121, 20733346.
32. Sifneos PE. Alexithymia: past and present. Am J Psychiatry 1996, 153:137-142.
33. Sifneos PE. The prevalence of 'alexithymic' characteristics in psychosomatic patients. Psychother Psychosom 1973, 22:255-262. 10.1159/000286529, 4770536.
34. Sifneos PE. Clinical observations on some patients suffering from a variety of psychosomatic diseases. Acta Medicina Psychosomatica 1967, 21:133-136.
35. Mantani T, Okamoto Y, Shirao N, Okada G, Yamawaki S. Reduced activation of posterior cingulate cortex during imagery in subjects with high degrees of alexithymia: a functional magnetic resonance imaging study. Biol Psychiatry 2005, 57:982-990. 10.1016/j.biopsych.2005.01.047, 15860338.
36. Kano M, Hamaguchi T, Itoh M, Yanai K, Fukudo S. Correlation between alexithymia and hypersensitivity to visceral stimulation in human. Pain 2007, 132:252-263. 10.1016/j.pain.2007.01.032, 17360119.
37. Moriguchi Y, Decety J, Ohnishi T, Maeda M, Mori T, Nemoto K, Matsuda H, Komaki G. Empathy and judging other's pain: an fMRI study of alexithymia. Cereb Cortex 2007, 17:2223-2234.
38. Moriguchi Y, Ohnishi T, Decety J, Hirakata M, Maeda M, Matsuda H, Komaki G. The human mirror neuron system in a population with deficient self-awareness: an fMRI study in alexithymia. Hum Brain Mapp 2009, 30:2063-2076. 10.1002/hbm.20653, 18781590.
39. Ohnishi T, Moriguchi Y, Matsuda H, Mori T, Hirakata M, Imabayashi E, Hirao K, Nemoto K, Kaga M, Inagaki M. The neural network for the mirror system and mentalizing in normally developed children: an fMRI study. Neuro Report 2004, 15:1483-1487.
40. Casile A, Caggiano V, Ferrari PF. The mirror neuron system: a fresh view. The Neuroscientist: a review journal bringing neurobiology, neurology and psychiatry 2011, 17:524-538.
41. Cattaneo L, Rizzolatti G. The mirror neuron system. Arch Neurol 2009, 66:557-560. 10.1001/archneurol.2009.41, 19433654.
42. Pineda JA. Sensorimotor cortex as a critical component of an 'extended' mirror neuron system: Does it solve the development, correspondence, and control problems in mirroring?. Behavioral and brain functions: BBF 2008, 4:47. 10.1186/1744-9081-4-47, 2577683, 18928566.
43. Iacoboni M, Mazziotta JC. Mirror neuron system: basic findings and clinical applications. Ann Neurol 2007, 62:213-218. 10.1002/ana.21198, 17721988.
44. Karlsson H, Naatanen P, Stenman H. Cortical activation in alexithymia as a response to emotional stimuli. Br J Psychiatry 2008, 192:32-38. 10.1192/bjp.bp.106.034728, 18174507.
45. Paula-Perez I, Martos-Perez J, Llorente-Comi M. Alexithymia and Asperger syndrome. Rev Neurol 2010, 50(Suppl 3):S85-S90.
46. Tani P, Lindberg N, Joukamaa M, Nieminen-von Wendt T, von Wendt L, Appelberg B, Rimon R, Porkka-Heiskanen T. Asperger syndrome, alexithymia and perception of sleep. Neuropsychobiology 2004, 49:64-70. 10.1159/000076412, 14981336.
47. Fitzgerald M, Bellgrove M. The overlap between alexithymia and Asperger's syndrome. J Autism Dev Disord 2006, 36:573-576. 10.1007/s10803-006-0096-z, 2092499, 16755385.
48. Fitzgerald M, Molyneux GUY. Overlap Between Alexithymia and Asperger's Syndrome. Am J Psychiatry 2004, 161:2134-2135. 10.1176/appi.ajp.161.11.2134, 15514424.
49. Moriguchi Y, Maeda M, Igarashi T, Ishikawa T, Shoji M, Kubo C, Komaki G. Age and gender effect on alexithymia in large, Japanese community and clinical samples: a cross-validation study of the Toronto Alexithymia Scale (TAS-20). BioPsychoSocial medicine 2007, 1:7. 10.1186/1751-0759-1-7, 1838425, 17371586.
50. Moriguchi Y, Ohnishi T, Lane RD, Maeda M, Mori T, Nemoto K, Matsuda H, Komaki G. Impaired self-awareness and theory of mind: an fMRI study of mentalizing in alexithymia. NeuroImage 2006, 32:1472-1482. 10.1016/j.neuroimage.2006.04.186, 16798016.
51. Abell F, Happé F, Frith U. Do triangles play tricks? Attribution of mental states to animated shapes in normal and abnormal development. Cogn Dev 2000, 15:1-16.
52. Bird G, Silani G, Brindley R, White S, Frith U, Singer T. Empathic brain responses in insula are modulated by levels of alexithymia but not autism. Brain: a journal of neurology 2010, 133:1515-1525.
53. Lane RD, Schwartz GE. Levels of emotional awareness: a cognitive-developmental theory and its application to psychopathology. Am J Psychiatry 1987, 144:133-143.
54. Piaget J, Brown TA, Kaegi CE, Rosenzweig MR. Intelligence and Affectivity: Their Relationship During Child Development (Annual Reviews monograph) 1981, Palo Alto: Annual Reviews Inc..
55. Taylor GJ. Affects, trauma, and mechanisms of symptom formation: a tribute to John C. Nemiah, MD (1918-2009). Psychother Psychosom 2010, 79:339-349. 10.1159/000320119, 20733344.
56. Galderisi S, Mancuso F, Mucci A, Garramone S, Zamboli R, Maj M. Alexithymia and cognitive dysfunctions in patients with panic disorder. Psychother Psychosom 2008, 77:182-188. 10.1159/000119738, 18332616.
57. Herbert BM, Herbert C, Pollatos O. On the relationship between interoceptive awareness and alexithymia: is interoceptive awareness related to emotional awareness?. J Pers 2011, 79:1149-1175. 10.1111/j.1467-6494.2011.00717.x, 21241306.
58. Vorst HCM, Bermond B. Validity and reliability of the Bermond-Vorst Alexithymia Questionnaire. Personal Individ Differ 2001, 30:413-434.
59. Bermond B, Vorst HC, Moormann PP. Cognitive neuropsychology of alexithymia: implications for personality typology. Cogn Neuropsychiatry 2006, 11:332-360. 10.1080/13546800500368607, 17354075.
60. De Gucht V, Fontaine J, Fischler B. Temporal stability and differential relationships with neuroticism and extraversion of the three subscales of the 20-item Toronto Alexithymia Scale in clinical and nonclinical samples. J Psychosom Res 2004, 57:25-33. 10.1016/S0022-3999(03)00577-4, 15256292.
61. Bailey PE, Henry JD. Alexithymia, somatization and negative affect in a community sample. Psychiatry Res 2007, 150:13-20. 10.1016/j.psychres.2006.05.024, 17258817.
62. De Gucht V. Stability of neuroticism and alexithymia in somatization. Compr Psychiatry 2003, 44:466-471. 10.1016/S0010-440X(03)00143-3, 14610725.
63. Karvonen JT, Veijola J, Kokkonen P, Laksy K, Miettunen J, Joukamaa M. Somatization and alexithymia in young adult Finnish population. Gen Hosp Psychiatry 2005, 27:244-249. 10.1016/j.genhosppsych.2005.04.005, 15993255.
64. Mattila AK, Kronholm E, Jula A, Salminen JK, Koivisto AM, Mielonen RL, Joukamaa M. Alexithymia and somatization in general population. Psychosom Med 2008, 70:716-722. 10.1097/PSY.0b013e31816ffc39, 18596251.
65. Cunningham WA, Arbuckle NL, Jahn A, Mowrer SM, Abduljalil AM. Aspects of neuroticism and the amygdala: chronic tuning from motivational styles. Neuropsychologia 2010, 48:3399-3404. 10.1016/j.neuropsychologia.2010.06.026, 20600183.
66. Harenski CL, Kim SH, Hamann S. Neuroticism and psychopathy predict brain activation during moral and nonmoral emotion regulation. Cogn Affect Behav Neurosci 2009, 9:1-15. 10.3758/CABN.9.1.1, 19246323.
67. Hooker CI, Verosky SC, Miyakawa A, Knight RT, D'Esposito M. The influence of personality on neural mechanisms of observational fear and reward learning. Neuropsychologia 2008, 46:2709-2724. 10.1016/j.neuropsychologia.2008.05.005, 18573512.
68. Cremers HR, Demenescu LR, Aleman A, Renken R, van Tol MJ, van der Wee NJ, Veltman DJ, Roelofs K. Neuroticism modulates amygdala-prefrontal connectivity in response to negative emotional facial expressions. NeuroImage 2010, 49:963-970. 10.1016/j.neuroimage.2009.08.023, 19683585.
69. Sifneos PE. Problems of psychotherapy of patients with alexithymic characteristics and physical disease. Psychother Psychosom 1975, 26:65-70. 10.1159/000286912, 1202547.
70. Gohm CL, Clore GL. Individual differences in emotional experience: Mapping available scales to processes. Personality and Social Psychology Bulletin 2000, 26:679-697.
71. Taylor GJ, Bagby RM, Parker JDA. Disorders of affect regulation: Alexithymia in medical and psychiatric illness 1999, New York: Cambridge University Press.
72. Zackheim L. Alexithymia: the expanding realm of research. J Psychosom Res 2007, 63:345-347. 10.1016/j.jpsychores.2007.08.011, 17905040.
73. Lane RD, Sechrest L, Reidel R, Weldon V, Kaszniak A, Schwartz GE. Impaired verbal and nonverbal emotion recognition in alexithymia. Psychosom Med 1996, 58:203-210.
74. Igarashi T, Komaki G, Lane RD, Moriguchi Y, Nishimura H, Arakawa H, Gondo M, Terasawa Y, Sullivan CV, Maeda M. The reliability and validity of the Japanese version of the Levels of Emotional Awareness Scale (LEAS-J). BioPsychoSocial medicine 2011, 5:2. 10.1186/1751-0759-5-2, 3042374, 21281491.
75. Honkalampi K, Hintikka J, Tanskanen A, Lehtonen J, Viinamaki H. Depression is strongly associated with alexithymia in the general population. J Psychosom Res 2000, 48:99-104. 10.1016/S0022-3999(99)00083-5, 10750635.
76. Saarijarvi S, Salminen JK, Toikka TB. Alexithymia and depression: a 1-year follow-up study in outpatients with major depression. J Psychosom Res 2001, 51:729-733. 10.1016/S0022-3999(01)00257-4, 11750295.
77. Coffey E, Berenbaum H, Kerns JG. The dimensions of emotional intelligence, alexithymia, and mood awareness: Associations with personality and performance on an emotional stroop task. Cognition and Emotion 2003, 17:671-679.
78. Velasco C, Fernandez I, Paez D, Campos M. Perceived emotional intelligence, alexithymia, coping and emotional regulation. Psicothema 2006, 18(Suppl):89-94.
79. Ikemi Y, Ikemi A. An oriental point of view in psychosomatic medicine. Psychother Psychosom 1986, 45:118-126. 10.1159/000287937, 3547451.
80. Russell JA. Core affect and the psychological construction of emotion. Psychol Rev 2003, 110:145-172.
81. James W. What is an Emotion?. Mind 1884, 9:188-205.
82. Russell JA, Barrett LF. Core affect, prototypical emotional episodes, and other things called emotion: dissecting the elephant. J Pers Soc Psychol 1999, 76:805-819.
83. Barrett LF. Variety is the spice of life: A psychological construction approach to understanding variability in emotion. Cognition & emotion 2009, 23:1284-1306. 10.1080/02699930902985894, 23555855.
84. Barrett LF, Mesquita B, Ochsner KN, Gross JJ. The experience of emotion. Annu Rev Psychol 2007, 58:373-403. 10.1146/annurev.psych.58.110405.085709, 1934613, 17002554.