Brain activation during the perception of stressful word stimuli concerning interpersonal relationships in anorexia nervosa patients with high degrees of alexithymia in an fMRI paradigm

Psychiatry Research - Neuroimaging

Volumn 201, Issue 2, 2012, Pages 113-119

  Miyake, Yoshie ^a   Okamoto, Yasumasa ^b   Onoda, Keiichi ^c   Shirao, Naoko ^b   Okamoto, Yuri ^a   Yamawaki, Shigeto ^b  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c SHIMANE UNIVERSITY   (Japan)

Author keywords

Alexithymia; Anorexia nervosa; Functional MRI; Interpersonal relationship words

Indexed keywords

ADULT; ALEXITHYMIA; AMYGDALOID NUCLEUS; ANOREXIA NERVOSA; ANTERIOR CINGULATE; ARTICLE; BOLD SIGNAL; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; EMOTIONALITY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUSIFORM GYRUS; HUMAN; HUMAN RELATION; INFERIOR FRONTAL GYRUS; MAJOR CLINICAL STUDY; NEUROIMAGING; ORBITAL CORTEX; PERCEPTION; POSTCENTRAL GYRUS; POSTERIOR CINGULATE; PREFRONTAL CORTEX; PRIORITY JOURNAL; STIMULUS; SUPERIOR TEMPORAL GYRUS;

ADULT; AFFECTIVE SYMPTOMS; ANOREXIA NERVOSA; AROUSAL; BRAIN; BRAIN MAPPING; DOMINANCE, CEREBRAL; ECHO-PLANAR IMAGING; FEMALE; FRONTAL LOBE; GYRUS CINGULI; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; INTERPERSONAL RELATIONS; MAGNETIC RESONANCE IMAGING; OXYGEN; READING; REFERENCE VALUES; SEMANTICS; TEMPORAL LOBE;

EID: 84859009654     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2011.07.014     Document Type: Article

References (66)

1. Aleman A. Feelings you can't imagine: towards a cognitive neuroscience of alexithymia. Trends in Cognitive Sciences 2005, 9:553-555.
2. Badgaiyan R.D., Posner M.I. Mapping the cingulate cortex in response selection and monitoring. NeuroImage 1998, 7:255-260.
3. Bagby R.M., Parker J.D.A., Taylor G.J. The twenty-item Toronto alexithymia scale-I. Item selection and cross validation of the factor structure. Journal of Psychosomatic Research 1994, 38:23-32.
4. Bagby R.M., Taylor G.J., Parker J.D.A. The twenty-item Toronto Alexithymia Scale-II. Convergent, discriminant, and concurrent validity. Journal of Psychosomatic Research 1994, 38:33-40.
5. Bermond B., Vorst H.C.M., Moormann P.P. Cognitive neuropsychology of alexithymia: implications for personality typology. Cognitive Neuropsychiatry 2006, 11:332-360.
6. Berthoz S., Artiges E., Van De Moortele P.F., Poline J.B., Rouquette S., Consoli S.M., Martinot J.L. Effect of impaired recognition and expression of emotions on frontocingulate cortices: an fMRI study of men with alexithymia. The American Journal of Psychiatry 2002, 159:961-967.
7. Bourke M.P., Taylor G.J., Parker J.D., Bagby R.M. Alexithymia in women with anorexia nervosa. A preliminary investigation. The British Journal of Psychiatry 1992, 161:240-243.
8. Bruch H. Perceptual and conceptual disturbances in anorexia nervosa. Psychosomatic Medicine 1962, 24:187.
9. Bruch H. Eating Disorders. Obesity, Anorexia Nervosa, and the Person Within 1973, Basic Books, New York.
10. Bruch H. Anorexia nervosa: therapy and theory. The American Journal of Psychiatry 1982, 139:1531.
11. Buchanan D.C., Waterhouse G.J., West S.C. A proposed neurophysiological basis of alexithymia. Psychotherapy and Psychosomatics 1980, 34:248-255.
12. Bydlowski S., Corcos M., Jeammet P., Paterniti S., Berthoz S., Laurier C., Chambry J., Consoil S.M. Emotion-processing deficits in eating disorders. International Journal of Eating Disorders 2005, 37:321-329.
13. Christopoulos G.I., Tobler P.N., Bossaerts P., Dolan R.J., Schultz W. Neural Correlates of value, risk, and risk aversion contributing to decision making under risk. The Journal of Neuroscience 2009, 29:12574-12583.
14. Cochrane C.E., Brewerton T.D., Wilson D.B., Hodges E.L. Alexithymia in the eating disorders. International Journal of Eating Disorders 1993, 24:219-222.
15. Corcos M., Guilbaud O., Speranza M., Paterniti S., Loas G., Stephan P., Jeammet P. Alexithymia and depression in eating disorders. Psychiatry Research 2000, 93:263-266.
16. Cox B.J., Kuch K., Parker J.D.A., Shulman I.D., Evans R.J. Alexithymia in somatoform disorder patients with chronic pain. Journal of Psychosomatic Research 1994, 38:523-527.
17. Damasio A.R., Grabowski T.J., Bechara A., Damasio H., Ponto L.L., Parvizi J., Hichwa R.D. Subcortical and cortical brain activity during the feeling of self-generated emotions. Nature Neuroscience 2000, 3:1049-1056.
18. De Groot J.M., Rodin G., Olmsted M.P. Alexithymia, depression, and treatment outcome in bulimia nervosa. Comprehensive Psychiatry 1995, 36:53-60.
19. Devinsky O., Morrell M.J., Vogt B.A. Contributions of anterior cingulated cortex to behaviour. Brain 1995, 118:279-306.
20. Eisenberger N.I., Lieberman M.D., Williams K.D. Does rejection hurt? An FMRI study of social exclusion. Science 2003, 302:290-292.
21. Elliott R., Rubinsztein J.S., Sahakian B.J., Dolan R.J. The neural basis of mood-congruent processing biases in depression. Archives of General Psychiatry 2002, 59:597-604.
22. Fairburn C.G., Harrison P.J. Eating disorders. Lancet 2003, 361:407-416.
23. First M.B., Spitzer R.L., Gibbon M., Williams J.B. Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-I: CV) 1997, American Psychiatric Press, Washington, D.C.
24. First M.B., Gibbon M., Spitzer R.L., Williams J.B., Benjamin L.S. Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) 1997, American Psychiatric Press, Washington, D.C.
25. Friston K.J., Holmes A.P., Worsley K.J. How many subjects constitute a study?. NeuroImage 1999, 10:1-5.
26. Fukunishi I., Nakagawa T., Nakamura H., Kikuchi M., Takubo M. Is alexithymic construct a culture-bound? Validity and reliability of the Japanese version of the 20-item Toronto Alexithymia Scale TAS-20 and modified Beth Israel Hospital Psychosomatic Questionnaire BIQ. Psychological Reports 1997, 80:787-799.
27. Garner D.M. Eating Disorder Inventory-2 (EDI-2) 1991, Psychological Assessment Resources, Odessa, F.L.
28. Gilboa-Schechtman E., Liora A., Eynat Z., Pablo J. Emotional processing in eating disorders: specific impairment or general distress related deficiency?. Depression and Anxiety 2006, 23:331-339.
29. Gusnard D.A., Akbudak E., Shlman G.L., Raichle M.E. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America 2001, 27:4259-4264.
30. Hoppe K.D., Bogen J.E. Alexithymia in twelve commissurotomized patients. Psychotherapy and Psychosomatics 1977, 28:148-155.
31. 15O-PET study. Brain 2003, 126:1474-1484.
32. Killgore W.D., Yurgelun-Todd D.A. Activation of the amygdala and anterior cingulated during nonconscious processing of sad versus happy faces. NeuroImage 2004, 21:1215-1223.
33. Kugel H., Eichmann M., Dannlowski U., Ohrmann P., Bauer J., Arolt V., Heindel W., Suslow T. Alexithymic features and automatic amygdala reactivity to facial emotion. Neuroscience Letters 2008, 435:40-44.
34. Lancaster J.L., Woldorff M.G., Parsons L.M., Liotti M., Freitas C.S., Rainey L., Kochunov P.V., Nickerson D., Mikiten S.A., Fox P.T. Automated Talairach atlas labels for functional brain mapping. Human Brain Mapping 2000, 10:120-131.
35. Lane R.D., Ahern G.L., Scwartz G.E., Kaszniak A.W. Is alexithymia the emotional equivalent of blindsight?. Biological Psychiatry 1997, 42:834-844.
36. Lane R.D., Reiman E.M., Axelrod B., Yun L.-S., Holmes A., Schwartz G.E. Neural correlates of levels of emotional awareness: evidence of an interaction between emotion and attention in the anterior cingulated cortex. Journal of Cognitive Neuroscience 1998, 10:525-535.
37. Laquatra T.A., Clopton J.R. Characteristics of alexithymia and eating disorders in college women. Addictive Behaviors 1994, 19:373-380.
38. Larsen J.K., Brand N., Bermond B., Hijman R. Cognitive and emotional characteristics of alexithymia. A review of neurobiological studies. Journal of Psychosomatic Research 2003, 54:533-541.
39. LeDoux J.E. The Emotional Brain, 384 1998, Simon and Schuster, New York.
40. Lévesque J., Eugene F., Joanette Y., Paquette V., Mensour B., Beaudoin G., Leroux J.M., Bourgouin P., Beauregard M. Neural circuitry underlying voluntary suppression of sadness. Biological Psychiatry 2003, 53:502-510.
41. Leweke F., Stark R., Milch W., Kurth R., Schienle A., Kirsch P., Stingl M., Reimer C., Vaitl D. Patterns of neuronal activity related to emotional stimulation in alexithymia. Psychotherapy, Psychosomatic, Medicine, Psychology 2004, 54:437-444.
42. Maddock R.J. Retrosplenial cortex and emotion: new insights from functional imaging studies of the human brain. Trends in Neurosciences 1999, 22:310-316.
43. Mantani T., Okamoto Y., Shirao N., Okada G., Yamawaki S. Reduced activation of posterior cingulated cortex during imagery in subjects with high degrees of alexithymia: a functional magnetic resonance imaging study. Biological Psychiatry 2005, 57:982-990.
44. Miller K.K., Deckersbach T., Rauch S.L., Fischman A.J., Grieco K.A., Herzog D.B., Klibanski A. Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosa. Psychiatry Research: Neuroimaging 2004, 132:197-207.
45. Moriguchi Y., Ohnishi T., Lane R.D., Maeda M., Mori T., Nemoto K., Matsuda H., Komaki G. Impaired self-awareness and theory of mind: an fMRI study of mentalizing in alexithymia. NeuroImage 2006, 32:1472-1482.
46. Moriguchi Y., Decety J., Ohnishi T., Maeda M., Mori T., Nemoto K., Matsuda H., Komaki G. Empathy and judging other's pain: an fMRI study of alexithymia. Cerebral Cortex 2007, 17:2223-2234.
47. Morris J.S., Ohman A., Dolan R.J. A subcortical pathway to the right amygdala mediating "unseen" fear. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:1680-1685.
48. Nemiah J.C. Alexithymia. theoretical considerations. Psychotherapy and Psychosomatics 1977, 28:199-206.
49. Nomura M., Ohira H., Haneda K., Iidaka T., Sadato N., Okada T., Yonekura Y. Functional association of the amygdala and ventral prefrontal cortex during cognitive evaluation of facial expressions primed by masked angry faces: an event-related fMRI study. NeuroImage 2004, 21:352-363.
50. Oldershaw A., Hambrook D., Stahl D., Tchanturia K., Treasure J., Schmidt U. The socio-emotional processing stream in Anorexia Nervosa. Neuroscience and Biobehavioural Reviews 2011, 35:970-988.
51. Oldfield R.C. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia 1971, 9:97-113.
52. Parker J.D., Taylor G.J., Bagby R.M. Alexithymia: relationship with ego defense and coping styles. Comprehensive Psychiatry 1998, 39:91-98.
53. Pujol J., Lopez A., Deus J., Cardoner N., Vallejo J., Capdevila A., Paus T. Anatomical variability of the anterior cingulate gyrus and basic dimensions of human personality. NeuroImage 2002, 15:847-855.
54. Rastam M., Gillberg C., Gillberg I.C., Johansson M. Alexithymia in anorexia nervosa: a controlled study using the 20-item Toronto Alexithymia Scale. Acta Psychiatrica Scandinavica 1997, 95:385-388.
55. Schmidt U., Jiwany A., Treasure J. A controlled study of alexithymia in eating disorders. Comprehensive Psychiatry 1993, 34:54-58.
56. Shirao N., Okamoto Y., Okamoto Y., Otagaki Y., Morinobu S., Yamawaki S. Ratings of negative body image words, negative emotion words and neutral words by eating disorder patients and healthy subjects. Brain Sciences and Mental Disorders 2003, 15:141-147.
57. Shirao N., Okamoto Y., Okada G., Ueda K., Yamawaki S. Gender differences in brain activity toward unpleasant linguistic stimuli concerning interpersonal relationships: An fMRI study. European Archives of Psychiatry and Clinical Neuroscience 2005, 255:327-333.
58. Talairach P.T.J. Co-planar Stereotaxic Atlas of the Human Brain 1988.
59. Taylor G.J. Psychoanalysis and empirical research: the example of patients who lack psychological mindedness. Journal of the American Academy of Psychoanalysis 1995, 23:263-281.
60. Taylor G.J. Recent developments in alexithymia theory and research. Canadian Journal of Psychiatry 2000, 45:134-142.
61. Taylor G.J., Parker J.D., Bagby R.M., Bourke M.P. Relationships between alexithymia and psychological characteristics associated with eating disorders. Journal of Psychosomatic Research 1996, 41:561-568.
62. Taylor G.J., Bagby R.M., Pauker J.D.A. Disorders of Affect Regulation: Alexithymia in Medical and Psychiatric Illness 1997, Cambridge University Press, Cambridge, United Kingdom.
63. Toglia M.P., Battig W.F. Handbook of Semantic Word Norms 1978, Lawrence Erlbaum, Hillsdale, N.J.
64. Van Hoesen G.W., Morecraft R.J., Vogt B.A. Connections of the monkey cingulate cortex. Neurobiology of Cingulate Cortex and Limbic Thalamus 1993, 249-284. Birkhäuser, Cambridge, United Kingdom. B.A. Vogt, M. Gabriel (Eds.).
65. Vogt B.A., Finch D.M., Olson C.R. Functional heterogeneity in cingulated cortex: the anterior executive and posterior evaluative regions. Cerebral Cortex 1992, 2:435-443.
66. Yonezawa H., Otagaki Y., Miyake Y., Okamoto Y., Yamawaki S. No differences are seen in the regional cerebral blood flow in the restricting type of anorexia nervosa compared with the binge eating/purging type. Psychiatry and Clinical Neurosciences 2008, 62:26-33.