Mirror neuron system: Basic findings and clinical applications

Annals of Neurology

Volumn 62, Issue 3, 2007, Pages 213-218

  Iacoboni, Marco ^a,b   Mazziotta, John C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Ahmanson Lovelace Brain Mapping Center in the Department of Neurology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTISM; COGNITION; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LEARNING; NERVE CELL; NEUROPHYSIOLOGY; PARIETAL LOBE; PREMOTOR CORTEX; PRIORITY JOURNAL; REVIEW; SOCIAL BEHAVIOR; STROKE;

ANIMALS; AUTISTIC DISORDER; CEREBRAL CORTEX; CEREBROVASCULAR ACCIDENT; HAND; HUMANS; LEARNING; MACACA; MOUTH; MOVEMENT; NEURONS; SOCIAL BEHAVIOR; VISUAL PERCEPTION;

EID: 34948846594     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.21198     Document Type: Review

References (66)

1. Rizzolatti G, Luppino G, Matelli M. The organization of the cortical motor system: new concepts. Electroencephalogr Clin Neurophysiol 1998;106:283-296.
2. Rizzolatti G, Luppino G. The cortical motor system. Neuron 2001;31:889-901.
3. Rizzolatti G, Matelli M. Two different streams form the dorsal visual system: anatomy and functions. Exp Brain Res 2003;153:146-157.
4. Bisiach E, Perani D, Vallar G, Berti A. Unilateral neglect: personal and extra-personal. Neuropsychologia 1986;24:759-767.
5. Halligan PW, Marshall JC. Left neglect for near but not far space in man. Nature 1991;350:498-500.
6. Rizzolatti G, Matelli M, Pavesi G. Deficits in attention and movement following the removal of postarcuate (area 6) and prearcuate (area 8) cortex in macaque monkeys. Brain 1983;106:655-673.
7. Bruce CJ, Goldberg ME. Primate frontal eye fields. I. Single neurons discharging before saccades. J Neurophysiol 1985;53:603-635.
8. Goldberg ME, Bruce CJ. Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal. J Neurophysiol 1990;64:489-508.
9. Barash S, Bracewell RM, Fogassi L, et al. Saccade-related activity in the lateral intraparietal area. I. Temporal properties; comparison with area 7a. J Neurophysiol 1991;66:1095-1108.
10. Barash S, Bracewell RM, Fogassi L, et al. Saccade-related activity in the lateral intraparietal area. II. Spatial properties. J Neurophysiol 1991;66:1109-1124.
11. Jeannerod M, Arbib MA, Rizzolatti G, Sakata H. Grasping objects: the cortical mechanisms of visuomotor transformation. Trends Neurosci 1995;18:314-320.
12. Fogassi L, Luppino G. Motor functions of the parietal lobe. Curr Opin Neurobiol 2005;15:626-631.
13. di Pellegrino G, Fadiga L, Fogassi L, et al. Understanding motor events: a neurophysiological study. Exp Brain Res 1992;91:176-180.
14. Gallese V, Fadiga L, Fogassi L, Rizzolatti G. Action recognition in the premotor cortex. Brain 1996;119(pt 2):593-609.
15. Rizzolatti G, Fadiga L, Gallese V, Fogassi L. Premotor cortex and the recognition of motor actions. Brain Res Cogn Brain Res 1996;3:131-141.
16. Ferrari PF, Gallese V, Rizzolatti G, Fogassi L. Mirror neurons responding to the observation of ingestive and communicative mouth actions in the monkey ventral premotor cortex. Eur J Neurosci 2003;17:1703-1714.
17. Rizzolatti G, Craighero L. The mirror-neuron system. Annu Rev Neurosci 2004;27:169-192.
18. Newman-Norlund RD, van Schie HT, van Zuijlen AM, Bekkering H. The mirror neuron system is more active during complementary compared with imitative action. Nat Neurosci 2007;10:817-818.
19. Umiltà MA, Kohler E, Gallese V, et al. I know what you are doing. A neurophysiological study. Neuron 2001;31:155-165.
20. Kohler E, Keysers C, Umiltà MA, et al. Hearing sounds, understanding actions: action representation in mirror neurons. Science 2002;297:846-848.
21. Keysers C, Kohler E, Umiltà MA, et al. Audiovisual mirror neurons and action recognition. Exp Brain Res 2003;153:628-636.
22. Fogassi L, Ferrari PF, Gesierich B, et al. Parietal lobe: from action organization to intention understanding. Science 2005;308:662-667.
23. Ferrari PF, Rozzi S, Fogassi L. Mirror neurons responding to observation of actions made with tools in monkey ventral pre-motor cortex. J Cogn Neurosci 2005;17:212-226.
24. Fadiga L, Fogassi L, Pavesi G, Rizzolatti G. Motor facilitation during action observation: a magnetic stimulation study. J Neurophysiol 1995;73:2608-2611.
25. Rizzolatti G, Fadiga L, Matelli M, et al. Localization of grasp representations in humans by PET: 1. Observation versus execution. Exp Brain Res 1996;111:246-252.
26. Grafton ST, Arbib MA, Fadiga L, Rizzolatti G. Localization of grasp representations in humans by positron emission tomography. 2. Observation compared with imagination. Exp Brain Res 1996;112:103-111.
27. Iacoboni M, Woods RP, Brass M, et al. Cortical mechanisms of human imitation. Science 1999;286:2526-2528.
28. Koski L, Wohlschläger A, Bekkering H, et al. Modulation of motor and premotor activity during imitation of target-directed actions. Cereb Cortex 2002;12:847-855.
29. Koski L, Iacoboni M, Dubeau MC, et al. Modulation of cortical activity during different imitative behaviors. J Neurophysiol 2003;89:460-471.
30. Wapner S, Cirillo L. Imitation of a model's hand movement: age changes in transposition of left-right relations. Child Dev 1968;39:887-894.
31. Heiser M, Iacoboni M, Maeda F, et al. The essential role of Broca's area in imitation. Eur J Neurosci 2003;17:1123-1128.
32. Buccino G, Vogt S, Ritzl A, et al. Neural circuits underlying imitation learning of hand actions: an event-related fMRI study. Neuron 2004;42:323-334.
33. Calvo-Merino B, Glaser DE, Grèzes J, et al. Action observation and acquired motor skills: an FMRI study with expert dancers. Cereb Cortex 2005;15:1243-1249.
34. Calvo-Merino B, Grèzes J, Glaser DE, et al. Seeing of doing? Influence of visual and motor familiarity in action observation. Curr Biol 2006;16:1905-1910.
35. Goldman A. Simulating minds: the philosophy, psychology, and neuroscience of mindreading. New York: Oxford University Press, 2006.
36. Gallese V, Goldman A. Mirror neurons and the simulation theory of mind-reading. Trends Cogn Sci 1998;2:493-501.
37. Iacoboni M, Molnar-Szakacs I, Gallese V, et al. Grasping the intentions of others with one's own mirror neuron system. PLoS Biol 2005;3:e79.
38. Carr L, Iacoboni M, Dubeau MC, et al. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sei U S A 2003;100:5497-5502.
39. Kaplan JT, Iacoboni M. Getting a grip on other minds: mirror neurons, intention understanding and cognitive empathy. Soc Neurosci 2006;1:175-183.
40. Gazzola V, Aziz-Zadeh L, Keysers C. Empathy and the somatotopic auditory mirror system in humans. Curr Biol 2006;16:1824-1829.
41. Avenanti A, Bueti D, Galati G, Aglioti SM. Transcranial magnetic stimulation highlights the sensorimotor side of empathy for pain. Nat Neurosci 2005;8:955-960.
42. Altschuler EL, Vankov A, Hubbard EM, et al. Mu wave blocking by observation of movement and its possible use to study the theory of other minds. Abstr Soc Neurosci 2000;68.1.
43. Williams JH, Whiten A, Suddendorf T, Perrett DI. Imitation, mirror neurons and autism. Neurosci Biobehav Rev 2001;25:287-295.
44. Iacoboni M, Dapretto M. The mirror neuron system and the consequences of its dysfunction. Nat Rev Neurosci 2006;7:942-951.
45. Rizzolatti G, Arbib MA. Language within our grasp. Trends Neurosci 1998;21:188-194.
46. Aziz-Zadeh L, Wilson SM, Rizzolatti G, Iacoboni M. Congruent embodied representations for visually presented actions and linguistic phrases describing actions. Curr Biol 2006;16:1818-1823.
47. Nishitani N, Avikainen S, Hari R. Abnormal imitation-related cortical activation sequences in Asperger's syndrome. Ann Neurol 2004;55:558-562.
48. Oberman LM, Hubbard EM, McCleery JP, et al. EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Brain Res Cogn Brain Res 2005;24:190-198.
49. Williams JH, Waiter GD, Gilchrist A, et al. Neural mechanisms of imitation and 'mirror neuron' functioning in autistic spectrum disorder. Neuropsychologia 2006;44:610-621.
50. Théoret H, Halligan E, Kobayashi M, et al. Impaired motor facilitation during action observation in individuals with autism spectrum disorder. Curr Biol 2005;15:R84-R85.
51. Hadjikhani N, Joseph RM, Snyder J, Tager-Flusberg H. Anatomical differences in the mirror neuron system and social cognition network in autism. Cereb Cortex 2006;16:1276-1282.
52. Dapretto M, Davies MS, Pfeifer JH, et al. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci 2006;9:28-30.
53. Rogers SJ, Pennington BF. A theoretical approach to the deficits in infantile autism. Dev Psychol 1991;3:137-162.
54. Williams JH, Whiten A, Singh T. A systematic review of action imitation in autistic spectrum disorder. J Autism Dev Disord 2004;34:285-299.
55. Field T, Sanders C, Nadel J. Children with autism display more social behaviors after repeated imitation sessions. Autism 2001;5:317-323.
56. Escalona A, Field T, Nadel J, Lundy B. Brief report: imitation effects on children with autism. J Autism Dev Disord 2002;32:141-144.
57. Ingersoll B, Lewis E, Kroman E. Teaching the imitation and spontaneous use of descriptive gestures in young children with autism using a naturalistic behavioral intervention. J Autism Dev Disord (in press).
58. Ingersoll B, Schreibman L. Teaching reciprocal imitation skills to young children with autism using a naturalistic behavioral approach: effects on language, pretend play, and joint attention. J Autism Dev Disord 2006;36:487-505.
59. Ingersoll B, Gergans S. The effect of a parent-implemented imitation intervention on spontaneous imitation skills in young children with autism. Res Dev Disabil 2007;28:163-175.
60. de Vries S, Mulder T. Motor imagety and stroke rehabilitation: a critical discussion. J Rehabil Med 2007;39:5-13.
61. Pomeroy VM, Clark CA, Miller JS, et al. The potential for utilizing the "mirror neurone system" to enhance recovery of the severely affected upper limb early after stroke: a review and hypothesis. Neurorehabil Neural Repair 2005;19:4-13.
62. Buccino G, Solodkin A, Small SL. Functions of the mirror neuron system: implications for neurorehabilitation. Cogn Behav Neurol 2006;19:55-63.
63. Ertelt D, Small S, Solodkin A, et al. Action observation has a positive impact on rehabilitation of motor deficits after stroke. Neuroimage 2007;36(suppl 2):T164-T173.
64. Nelissen K, Luppino G, Vanduffel W, et al. Observing others: multiple action representation in the frontal lobe. Science 2005;310:332-336.
65. Mukamel R, Ekstrom AD, Kaplan J, et al. Mirror properties of single cells in human medial frontal cortex. Abstr Soc Neurosci 2007.
66. Iacoboni M. Neural mechanisms of imitation. Curr Opin Neurobiol 2005;15:632-637.