Neural substrates of affective face recognition in alexithymia: A functional magnetic resonance imaging study

Neuropsychobiology

Volumn 63, Issue 2, 2011, Pages 119-124

  Lee, Byeong Taek ^a   Lee, Hwa Young ^b   Park, Sae Ah ^c   Lim, Jin Young ^b   Tae, Woo Suk ^d   Lee, Min Soo ^c   Joe, Sook Haeng ^c   Jung, In Kwa ^c   Ham, Byung Joo ^b  

^a Seoul National University   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c Korea University   (South Korea)

^d Kangwon National University   (South Korea)

Author keywords

Alexithymia; Facial stimuli; Functional magnetic resonance imaging

Indexed keywords

ADULT; AFFECT; ALEXITHYMIA; ANGER; ARTICLE; BRAIN FUNCTION; COGNITION; EMOTION; FACE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; IMAGING SYSTEM; NEUROIMAGING; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PSYCHOLOGICAL RATING SCALE; VISUAL STIMULATION; WHOLE BODY SCANNER;

ADULT; AFFECTIVE SYMPTOMS; BRAIN; BRAIN MAPPING; EMOTIONS; FACIAL EXPRESSION; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; RECOGNITION (PSYCHOLOGY);

EID: 78650638257     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000318086     Document Type: Article

References (43)

1. Taylor GJ: Recent developments in alexithymia theory and research. Can J Psychiatry 2000; 45: 134-142.
2. Hoppe KD, Bogen JE: Alexithymia in twelve commissurotomized patients. Psychother Psychosom 1977; 28: 148-155.
3. Zeitlin SB, Lane RD, O'Leary DS, Schrift MJ: Interhemispheric transfer deficit and alexithymia. Am J Psychiatry 1989; 146: 1434-1439.
4. Parker JD, Keightley ML, Smith CT, Taylor GJ: Interhemispheric transfer deficit in alexithymia: an experimental study. Psychosom Med 1999; 61: 464-468.
5. Parker JD, Taylor GJ, Bagby RM: Alexithymia and the recognition of facial expressions of emotion. Psychother Psychosom 1993; 59: 197-202.
6. Lane RD, Sechrest L, Reidel R, Weldon V, Kaszniak A, Schwartz GE: Impaired verbal and nonverbal emotion recognition in alexithymia. Psychosom Med 1996; 58: 203-210.
7. Lane RD, Ahern GL, Schwartz GE, Kaszniak AW: Is alexithymia the emotional equivalent of blindsight? Biol Psychiatry 1997; 42: 834-844.
8. Berthoz S, Artiges E, Van De Moortele PF, Poline JB, Rouquette S, Consoli SM, Martinot JL: Effect of impaired recognition and expression of emotions on frontocingulate cortices: an fMRI study of men with alexithymia. Am J Psychiatry 2002; 159: 961-967.
9. Kano M, Fukudo S, Gyoba J, Kamachi M, Tagawa M, Mochizuki H, Itoh M, Hongo M, Yanai K: Specific brain processing of facial expressions in people with alexithymia: An H2 15O-PET study. Brain 2003; 126: 1474-1484.
10. Phillips ML, Drevets WC, Rauch SL, Lane R: Neurobiology of emotion perception. I. The neural basis of normal emotion perception. Biol Psychiatry 2003; 54: 504-514. (Pubitemid 37289437)
11. Gundel H, Lopez-Sala A, Ceballos-Baumann AO, Deus J, Cardoner N, Marten-Mittag B, Soriano-Mas C, Pujol J: Alexithymia correlates with the size of the right anterior cingulate. Psychosom Med 2004; 66: 132-140.
12. Heilman KM: The neurobiology of emotional experience. J Neuropsychiatry Clin Neurosci 1997; 9: 439-448.
13. Mantani T, Okamoto Y, Shirao N, Okada G, Yamawaki S: Reduced activation of posterior cingulate cortex during imagery in subjects with high degrees of alexithymia: a functional magnetic resonance imaging study. Biol Psychiatry 2005; 57: 982-990.
14. Kugel H, Eichmann M, Dannlowski U, Ohrmann P, Bauer J, Arolt V, Heindel W, Suslow T: Alexithymic features and automatic amygdala reactivity to facial emotion. Neurosci Lett 2008; 435: 40-44.
15. Eichmann M, Kugel H, Suslow T: Difficulty identifying feelings and automatic activation in the fusiform gyrus in response to facial emotion. Percept Mot Skills 2008; 107: 915-922.
16. Reker M, Ohrmann P, Rauch AV, Kugel H, Bauer J, Dannlowski U, Arolt V, Heindel W, Suslow T: Individual differences in alexithymia and brain response to masked emotion faces. Cortex 2010; 46: 658-667.
17. Blair RJ, Morris JS, Frith CD, Perrett DI, Dolan RJ: Dissociable neural responses to facial expressions of sadness and anger. Brain 1999; 122(part 5):883-893.
18. Drexler K, Schweitzer JB, Quinn CK, Gross R, Ely TD, Muhammad F, Kilts CD: Neural activity related to anger in cocaine-dependent men: a possible link to violence and relapse. Am J Addict 2000; 9: 331-339.
19. Murphy FC, Nimmo-Smith I, Lawrence AD: Functional neuroanatomy of emotions: a meta-analysis. Cogn Affect Behav Neurosci 2003; 3: 207-233.
20. Lee BT, Ham BJ: Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. Genes Brain Behav 2008; 7: 899-905.
21. Oldfield RC: The assessment and analysis of handedness: The Edinburgh Inventory. Neuropsychologia 1971; 9: 97-113.
22. Shin MS, Kim ZS, Park KB: The cut-off score for the Korean version of Beck Depression Inventory. Korean Clin Psychol 1993; 12: 71-81.
23. Han JH, Lee SP, Lee SJ, Do KY, Hong SC, Kim EH, Kim KS, Lew TY: Development of Korean version of alexithymia scale: reliability and validity of SSPS (Schalling-Sifneos Personality Scale) and TAS (Toronto Alexithymia Scale). Korean J Psychosom Med 1995; 3: 147-158.
24. Bagby RM, Parker JD, Taylor GJ: The Twenty- Item Toronto Alexithymia Scale - I. Item selection and cross-validation of the factor structure. J Psychosom Res 1994; 38: 23-32.
25. Lee WH, Chae JH, Bahk WM, Lee KU: Development and its preliminary standardization of pictures of facial expressions for affective neurosciences. J Korean Neuro - psychiatr Assoc 2004; 43: 552-558.
26. Seminowicz DA, Mayberg HS, McIntosh AR, Goldapple K, Kennedy S, Segal Z, Rafi-Tari S: Limbic-frontal circuitry in major depression: a path modeling metanalysis. Neuroimage 2004; 22: 409-418.
27. Alexander GE, DeLong MR, Strick PL: Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 1986; 9: 357-381.
28. Alexander GE, Crutcher MD, DeLong MR: Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, 'prefrontal' and 'limbic' functions. Prog Brain Res 1990; 85: 119-146.
29. Phan KL, Wager T, Taylor SF, Liberzon I: Functional neuroanatomy of emotion: A meta- analysis of emotion activation studies in PET and fMRI. Neuroimage 2002; 16: 331-348.
30. Berman KF, Weinberger DR: The prefrontal cortex in schizophrenia and other neuropsychiatric diseases: in vivo physiological correlates of cognitive deficits. Prog Brain Res 1990; 85: 521-536, discussion 536-537.
31. Lane RD, Reiman EM, Axelrod B, Yun LS, Holmes A, Schwartz GE: Neural correlates of levels of emotional awareness: evidence of an interaction between emotion and attention in the anterior cingulate cortex. J Cogn Neurosci 1998; 10: 525-535.
32. Meriau K, Wartenburger I, Kazzer P, Prehn K, Lammers CH, van der Meer E, Villringer A, Heekeren HR: A neural network reflecting individual differences in cognitive processing of emotions during perceptual decision making. Neuroimage 2006; 33: 1016-1027.
33. Vermeulen N, Luminet O, Corneille O: Alexithymia and the automatic processing of affective information: evidence from the affective priming paradigm. Cogn Emot 2006; 20: 64-91.
34. Rossignol M, Anselme C, Vermeulen N, Philippot P, Campanella S: Categorical perception of anger and disgust facial expression is affected by non-clinical social anxiety: An ERP study. Brain Res 2007; 1132: 166-176.
35. Leweke F, Stark R, Milch W, Kurth R, Schienle A, Kirsch P, Stingl M, Reimer C, Vaitl D: Patterns of neuronal activity related to emotional stimulation in alexithymia (in German). Psychother Psychosom Med Psychol 2004; 54: 437-444.
36. Calder AJ, Keane J, Lawrence AD, Manes F: Impaired recognition of anger following damage to the ventral striatum. Brain 2004; 127: 1958-1969.
37. Sprengelmeyer R, Rausch M, Eysel UT, Przuntek H: Neural structures associated with recognition of facial expressions of basic emotions. Proc Biol Sci 1998; 265: 1927-1931.
38. Phillips ML, Williams L, Senior C, Bullmore ET, Brammer MJ, Andrew C, Williams SC, David AS: A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics. Psychiatry Res 1999; 92: 11-31.
39. Schaefer A, Collette F, Philippot P, van der Linden M, Laureys S, Delfiore G, Degueldre C, Maquet P, Luxen A, Salmon E: Neural correlates of 'hot' and 'cold' emotional processing: a multilevel approach to the functional anatomy of emotion. Neuroimage 2003; 18: 938-949.
40. Kimbrell TA, George MS, Parekh PI, Ketter TA, Podell DM, Danielson AL, Repella JD, Benson BE, Willis MW, Herscovitch P, Post RM: Regional brain activity during transient self-induced anxiety and anger in healthy adults. Biol Psychiatry 1999; 46: 454-465.
41. Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, Mathews VP, Kalnin A, Lowe MJ: Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry 2005; 57: 1079-1088.
42. Parker JD, Bagby RM, Taylor GJ: Alexithymia and depression: Distinct or overlapping constructs? Compr Psychiatry 1991; 32: 387-394.
43. Zech E, Luminet O, Rime B, Wagner H: Alexithymia and its measurement: Confirmatory factor analyses of the 20-Item Toronto Alexithymia Scale and the Bermond-Vorst Alexithymia Questionnaire. Eur J Pers 1999; 13: 511-532.