Androgens and bone

Minerva Endocrinologica

Volumn 37, Issue 4, 2012, Pages 305-314

  De Oliveira, D H A ^a   Fighera, T M ^a   Bianchet, L C ^a   Kulak, C A M ^a   Kulak, J ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Androgens; Bone and bones; Estrogens; Testosterone

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTENEDIONE; AROMATASE; ESTRADIOL; PRASTERONE; PRASTERONE SULFATE; TESTOSTERONE;

BONE; BONE CELL; HORMONE METABOLISM; HUMAN; HYPOGONADISM; REVIEW; SEX DIFFERENTIATION;

ADRENAL GLANDS; ANDROGEN-INSENSITIVITY SYNDROME; ANDROGENS; ANIMALS; APOPTOSIS; AROMATASE; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; ESTRADIOL; FEMALE; GONADS; HOMEOSTASIS; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOGONADISM; MALE; MENOPAUSE; ORCHIECTOMY; OSTEOBLASTS; OSTEOCLASTS; OSTEOPOROSIS; RECEPTORS, ANDROGEN; SEX CHARACTERISTICS; TESTOSTERONE;

EID: 84875282191     PISSN: 03911977     EISSN: 18271634     Source Type: Journal    
DOI: None     Document Type: Review

References (84)

1. Leder BZ, LeBlanc KM, Schoenfeld DA, Eastell R, Finkelstein JS. Differential effects of androgens and estrogens on bone turnover in normal men. J Clin Endocrinol Metab 2003;88:204-10. (Pubitemid 36115166)
2. Orwoll ES. Osteoporosis in men. Endocrinol Metab Clin North Am 1998;27:349-67. (Pubitemid 28285868)
3. Kasperk CH, Wergedal JE, Farley JR, Linkhart TA, Turner RT, Baylink DJ. Androgens directly stimulate proliferation of bone cells in vitro. Endocrinology 1989;124:1576-78. (Pubitemid 19082736)
4. Kasperk CH, Wakley GK, Hierl T, Ziegler R. Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. J Bone Miner Res 1997;12:464-71. (Pubitemid 27120484)
5. Pederson L, Kremer M, Judd J, Pascoe D, Spelsberg TC, Riggs BL et al. Androgens regulate bone resorption activity of isolated osteoclasts in vitro. Proc Natl Acad Sci USA 1999;96:505-10. (Pubitemid 29061238)
6. Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dalrymple SA et al. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest 1995;95:2886-95.
7. Wakley GK, Schutte Jr HD, Hannon KS, Turner RT. Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. J Bone Miner Res 1991;6:325-30.
8. Riggs BL, Khosla S, Melton LJ. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 2002;23:279-302. (Pubitemid 34651948)
9. Longcope C. Metabolism of estrogens and progestins. In: Fraser Jr IS, Lobo RA, Whitehead MI, editors. Estrogens and progestens in clinical practice. New York: Churchill Livingstone; 1998. p. 89-94.
10. Fujikawa H, Okura F, Kuwano Y, Sekizawa A, Chiba H, Shimodaira K et al. Steroid sulfatase activity in osteoblast cells. Biochem Biophys Res Commun 1997;231:42-7. (Pubitemid 27212106)
11. Saito H, Yanaihara T. Steroid formation in osteoblast-like cells. J Int Med Res 1998;26:1-12. (Pubitemid 28066175)
12. ssen JM, Bland R, Hewison M, Coughtrie MW, Sharp S, Arts J et al. Estradiol formation by human osteoblasts via multiple pathways: relation with osteoblast function. J Cell Biochem 1999;75:528-37.
13. Van Der Eerden BC, Van De Ven J, Lowik CW, Wit JM, Karperien M. Sex steroid metabolism in the tibial growth plate of the rat. Endocrinology 2002;143:4048-55. (Pubitemid 35244384)
14. Clarke BL, Khosla S. Androgens and bone. Steroids 2009;74:296-305.
15. Goldray D, Weisman Y, Jaccard N, Merdler C, Chen J, Matzin H. Increased bone density in elderly men treated with the gonadotrophin releasing hormone agonistapeptyl. J Clin Endocrinol Metab 1993;76:288-90. (Pubitemid 23073043)
16. Finkelstein JS, Klibanski A, Neer RM, Doppelt SH, Rosenthal DI, Segre GV et al. Increases in bone density during treatment of men with idiopathic hypogonadotrophic hypogonadism. J Clin Endocrinol Metab 1989;69:776-83. (Pubitemid 19245856)
17. Dixon JE, Rodin A, Murby B, Chapman MG, Fogelman I. Bone mass in hirsute women with androgen excess. Clin Endocrinol (Oxf) 1989;30:271-7. (Pubitemid 19074808)
18. Need AG, Horowitz M, Walker CJ, Chatterton BE, Chapman K, Nordin BEC. Cross-over study of fat-corrected forearm mineral content during nandroloneanoate therapy for osteoporosis. Bone 1989;10:3-6. (Pubitemid 19134737)
19. Vanderschueren D, Bouillon R. Androgens and bone. Calcif Tissue Int 1995;56:341-6.
20. Colvard DS, Eriksen EF, Keeting PE, Wilson EM, Lubahn DB, French FS et al. Identification of androgen receptors in normal human osteoblast-like cells. Proc Natl Acad Sci USA 1989;86:854-7. (Pubitemid 19056254)
21. Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G et al. Mechanisms of estrogen action. Physiol Rev 2001;81:1535-65. (Pubitemid 32951806)
22. Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L et al. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 2001;104:719-30. (Pubitemid 32241022)
23. Heinlein CA, Chang C. Androgen receptor (AR) coregulators: an overview. Endocr Rev 2002;23:175-200. (Pubitemid 34299023)
24. Abu EO, Horner A, Kusec V, Triffitt JT, Compston JE. The localization of androgens receptors in human bone. J Clin Endocrinol Metab 1997;82:3493-7. (Pubitemid 27419110)
25. Ben-Hur H, Thole HH, Mashiah A, Insler V, Berman V, Shezen E et al. Estrogen, progesterone and testosterone receptors in human fetal cartilaginous tissue: immunohistochemical studies. Calcif Tissue Int 1997;60:520-6. (Pubitemid 27230011)
26. Carrascosa A, Audi L, Fernandez MA, Balabriga A. Biological effects of androgens and identification of especific dihydrotestosterona-binding sites in cultured human fetal epiphyseal chondrocytes. J Clin Endocrinol Metab 1990;70:134-40.
27. Bord S, Horner A, Beavan S, Compston J. Estrogen receptors α and β are differentially expressed in developing human bone. J Clin Endocrinol Metab 2001;86:2309-14. (Pubitemid 32472956)
28. Nilsson LO, Boman A, Savendahl L, Grigelioniene G, Ohlsson C, Ritzen EM et al. Demonstration of estrogen receptor-β immunoreactivity in human growth plate cartilage. J Clin Endocrinol Metab 1999;84:370-3. (Pubitemid 29036729)
29. Wiren KM, Zhang X, Chang C, Keenan E, Orwoll ES. Transcriptional up-regulation of the human androgen receptor by androgen in bone cells. Endocrinology 1997;138:2291-300. (Pubitemid 27215228)
30. Wiren KM, Chapman EA, Zhang XW. Osteoblast differentiation influences androgen and estrogen receptor-alpha and -beta expression. J Endocrinol 2002;175:683-94.
31. Mizuno Y, Hosoi T, Inoue S, Ikegami A, Kaneki M, Akedo Y et al. Immunocytochemical identification of androgen receptor in mouse osteoclast-like cells. Calcif Tissue Int 1994;54:325-6. (Pubitemid 24097837)
32. Fiorelli G, Gori F, Petilli M, Tanini A, Benvenuti S, Serio M et al. Functional estrogen receptors in a human preosteoclastic cell line. Proc Natl Acad Sci USA 1995;92:2672-6.
33. Kusec V, Virdi AS, Prince R, Triffitt JT. Localization of estrogen receptor-alpha in human and rabbit skeletal tissues. J Clin Endocrinol Metab 1998;83:2421-8. (Pubitemid 28503041)
34. Collier FM, Huang WH, Holloway WR, Hodge JM, Gillespie MT, Daniels LL et al. Osteoclasts from human giant cell tumors of bone lack estrogen receptors. Endocrinology 1998;139:1258-67. (Pubitemid 28510146)
35. Gruber R, Czerwenka K, Wolf F, Ho GM, Willheim M, Peterlik M. Expression of the vitamin D receptor, of estrogen and thyroid hormone receptor α and β isoforms, and of the androgen receptor in culture of native mouse bonerow and of stromal osteobalstic cells. Bone 1999;24:465-73. (Pubitemid 29234135)
36. Braidman IP, Hainey L, Batra G, Selby PL, Sauders PT, Hoyland JA. Localization of estrogen receptor β protein expression in adult human bone. J Bone Miner Res 2001;16:214-20. (Pubitemid 32105402)
37. McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rev 1999;20:279-307. (Pubitemid 30649809)
38. Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T et al. Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest 2003;111:1651-64. (Pubitemid 38057747)
39. Lorenzo J. A new hypothesis for how sex steroid hormones regulate bone mass. J Clin Invest 2003;111:1641-43. (Pubitemid 38057743)
40. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C. Androgens and Bone. Endocr Rev 2004;25:389-425. (Pubitemid 38786452)
41. Ren SG, Malozowski S, Sanchez P, Sweet DE, Loriaux DL, Cassorla F. Direct administration of testosterone increases rat tibial epiphyseal growth plate width. Acta Endocrinol (Copenh) 1989;121:401-5. (Pubitemid 19224916)
42. Kerrigan JR, Rogol AD. The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence. Endocr Rev 1992;13:281-98.
43. Masuyama A, Ouchi Y, Sato F, Hosoi T, Nakamura T, Orimo H. Characteristics of steroid hormone receptors in cultured MC3T3-E1 osteoblastic cells and effect of steroid hormones on cell proliferation. Calcif Tissue Int 1992;51:376-81. (Pubitemid 23019418)
44. Kasperk C, Fitzsimmons R, Strong D, Mohan S, Jennings J, Wergedal J et al. Studies of the mechanism by which androgens enhance mitogenesis and differentiation in bone cells. J Clin Endrocrinol Metab 1990;71:1322-9.
45. Pilbeam CC, Raisz LG. Effects of androgens on parathyroid hormone and interleukin-1-stimulated prostaglandin production in cultured neonatal mouse calvariae. J Bone Miner Res 1990;5:1183-8. (Pubitemid 20373527)
46. Fukuyama S, Tashjian Jr AH. Direct modulation by estradiol of the response of human bone cells (SaOS-2) to human parathyroid hormone (PTH) and PTH-related protein. Endocrinology 1989;124:397-401. (Pubitemid 19033672)
47. Pivirotto LA, Cissel DS, Keeting PE. Sex hormones mediate interleukin-1-beta production by human osteoblastic HOBIT cells. Mol Cell Endocrinol 1995;111:67-74.
48. Hofbauer LC, Hicok KC, Chen D, Khosla S. Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells. Eur J Endocrinol 2002;147:269-73.
49. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999;20:345-57. (Pubitemid 30649812)
50. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. Endocrinology 1997;138:4013-21. (Pubitemid 27351958)
51. Huber DM, Bendixen AC, Pathrose P, Srivastava S, Dienger KM, Shevde NK et al. Androgens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factor. Endocrinology 2001;142:3800-8. (Pubitemid 32802650)
52. Smith MR. Osteoporosis during androgen deprivation therapy for prostate cancer. Urology 2002;60(3 Suppl 1):79-85;discussion 86.
53. Stoch SA, Parker RA, Chen L, Bubley G, Ko YJ, Vincelette A et al. Bone loss in men with prostate cancer treated with gonadotropin-releasing hormone agonists. J Clin Endocrinol Metab 2001;86:2787-91. (Pubitemid 32545740)
54. Smith MR, McGovern FJ, Zietman AL, Fallon MA, Hayden DL, Schoenfeld DA et al. Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. N Engl J Med 2001;345:948-55.
55. Leder BZ, Finkelstein JS. Gonadal steroids and the skeleton in men. Clinical aspects. In: Orwoll ES, Bliziotes M, eds. Osteoporosis. Pathophysiology and clinical management. Totowa, NJ: Humana Press 2002;393-411.
56. Francis RM. The effects of testosterone on osteoporosis in men. Clin Endocrinol (Oxf) 1999;50:411-14. (Pubitemid 29193222)
57. Baillie SP, Davison CE, Johnson FJ, Francis RM. Pathogenesis of vertebral crush fractures in men. Age Ageing 1992;21:139-41.
58. Meier C, Nguyen TV, Handelsman DJ, Schindler C, Kushnir MM, Rockwood AL et al. Endogenous sex hormones and incident fracture risk in older men. Arch Intern Med 2008;168:47-54.
59. Barrett-Connor E, Mueller JE, von Muhlen DG, Laughlin GA, Schneider DL, Sartoris DJ. Low levels of estradiol are associated with vertebral fractures in older men, but not women: the Rancho Bernardo Study. J Clin Endocrinol Metab 2000;85:219-23. (Pubitemid 32268817)
60. Amin S, Zhang Y, Felsen DT, Sawin CT, Hannan MT, Wilson PWF et al. Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study. Am J Med 2006;119:426-33.
61. Leifke E, Korner HC, Link TM, Behre HM, Peters PE, Nieschlag E. Effects of testosterone replacement therapy on cortical and trabecular bone mineral density, vertebral body area and paraspinal muscle area in hypogonadal men. Eur J Endocrinol 1998;138:51-8. (Pubitemid 28078809)
62. Finkelstein JS, Klibanski A, Neer RM. A longitudinal evaluation of bone mineral density in adult men with histories of delayed puberty. J Clin Endocrinol Metab 1996;81:1152-5. (Pubitemid 26083985)
63. Bertelloni S, Baroncelli GI, Ferdeghini M, Perri G, Saggese G. Normal volumetric bone mineral density and bone turnover in young men with histories of constitutional delay of puberty. J Clin Endocrinol Metab 1998;83:4280-3. (Pubitemid 29100122)
64. Bertelloni S, Baroncelli GI, Federico G, Cappa M, Lala R, Saggese G. Altered bone mineral density in patients with complete androgen insensitivity syndrome. Horm Res 1998;50:309-14. (Pubitemid 29080602)
65. Labrie F, Belanger A, Cusan L, Gomez JL, Candas B. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. Endocrinology 1997;82:2396-402. (Pubitemid 27337846)
66. Zborowski JV, Cauley JA, Talbott EO, Guzick DS, Winters SJ. Bone mineral density, androgens, and the polycystic ovary: the complex and controversial issue of androgenic influence. J Clin Endocrinol Metab 2000;85:3496-506.
67. Barrett-Connor E, Kritz-Silverstein D, Edelstein SL. A prospective study of dehydroepiandrosterone sulfate (DHEAS) and bone mineral density in older men and women. Am J Epidemiol 1993;137:201-6. (Pubitemid 23083672)
68. Greendale GA, Edelstein S, Barrett-Connor E. Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo study. J Bone Miner Res 1997;12:1833-43. (Pubitemid 27500195)
69. Behre HM, Kliesch S, Liefke E, Link TM, Nieschlag E. Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab 1997;82:2386-90. (Pubitemid 27337844)
70. Katznelson L, Finkelstein JS, Schoenfeld DA, Rosenthal DI, Anderson EJ, Klibanski A. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996;81:4358-65. (Pubitemid 26412044)
71. Wang C, Eyre DR, Clark K, Kleinberg D, Newman C, Iranmanesh A et al. Sublingual testosterone replacement improves muscle mass and strength, reases bone resorption, and increases bone formationkers in hypogonadal men - a clinical research center study. J Clin Endocrinol Metab 1996;81:3654-62. (Pubitemid 26339933)
72. Snyder PJ, Peachey H, Berlin JA, Hannoush P, Haddad G, Diewati A et al. Effects of testosterone replacement in hypogonadal men. J Clin Endocrinol Metab 2000;85:2670-7. (Pubitemid 32269134)
73. Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Synder PJ, Cunningham G et al. Effects of transdermal testosterone gel on bone turnoverkers and bone mineral density in hypogonadal men. Clin Endocrinol (Oxf) 2001;54:739-50. (Pubitemid 34208885)
74. Guo C-Y, Jones TH, Eastell R. Treatment of isolated hypogonadotropic hypogonadism effect on bone mineral density and bone turnover. J Clin Endocrinol Metab 1997;82:658-65. (Pubitemid 27068647)
75. Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G et al. Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. Testosterone Gel Study Group. J Clin Endocrinol Metab 2000;85:2839-53. (Pubitemid 32269162)
76. Anderson FH, Francis RM, Faulkner K. Androgen supplementation in eugonadal men with osteoporosis effects of 6 months of treatment on bone mineral density and cardiovascular risk factors. Bone 1996;18:171-7. (Pubitemid 26092597)
77. Reid IR, Wattie DJ, Evans MC, Stapleton JP. Testosterone therapy in glucocorticoid-treated men. Arch Intern Med 1996;156:1173-7. (Pubitemid 26196245)
78. Bertelloni S, Baroncelli GI, Battini R, Perri G, Saggese G. Short-term effects of testosterone treatment on reduced bone density in boys with constitutional delay of puberty. J Bone Miner Res 1995;10:1488-95.
79. Raisz LG, Wiita B, Artis A, Bowen A, Schwartz S, Trahiotis M et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemicalkers of bone formation and resorption in postmenopausal women. J Clin Endocrinol 1996;81:37-43. (Pubitemid 26035768)
80. Matzkin H, Chen J, Weisman Y, Goldray D, Pappas F, Jaccard N et al. Prolonged treatment with finasteride (a 5 α-reductase inhibitor) does not affect bone density and metabolism. Clin Endocrinol (Oxf) 1992;37:432-6.
81. Tollin SR, Rosen HN, Zurowski K, Saltzman B, Zeind AJ, Berg S et al. Finasteride therapy does not alter bone turnover in men with benign prostate hyperplasia - a clinical research center study. J Clin Endocrinol Metab 1996;81:1031-4. (Pubitemid 26083967)
82. Taxel P, Kennedy DG, Fall PM, Willard AK, Clive JM, Raisz LG. The effect of aromatase inhibition on sex steroids, gonadotropins, andkers of bone turnover in older men. J Clin Endocrinol Metab 2001;86:2869-74. (Pubitemid 32545754)
83. Doran PM, Riggs BL, Atkinson EJ, Khosla S. Effects of raloxifene, a selective estrogen receptor modulator, on bone turnoverkers and serum sex steroid and lipid levels in elderly men. J Bone Miner Res 2001;16:2118-25. (Pubitemid 32995404)
84. Falahati-Nini A, Riggs BL, Atkinson EJ, O'Fallon WM, Eastell R, Khosla S. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest 2000;106:1553-60. (Pubitemid 32038592)