Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo

Neurobiology of Aging

Volumn 34, Issue 6, 2013, Pages 1621-1631

  Godsave, Susan F ^a   Wille, Holger ^b,e   Pierson, Jason ^a,c   Prusiner, Stanley B ^b   Peters, Peter J ^a,d  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Thermo Fisher Scientific   (United States)

^d DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cryo immunogold EM; Neurodegeneration; Plasma membrane; Prion; PrPSc; Synapse

Indexed keywords

ANIMAL TISSUE; ARTICLE; CELL CONTACT; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; CLUSTER ANALYSIS; DEATH; DENDRITE; ELECTRON TOMOGRAPHY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOGOLD LABELING; IN VIVO STUDY; INCUBATION TIME; MOUSE; NERVE DEGENERATION; NERVE FIBER; NEUROPATHOLOGY; NEUROPIL; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; TERMINAL DISEASE; TOMOGRAPHY;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CELL COMMUNICATION; CELL MEMBRANE; MICE; PRION DISEASES; PRPSC PROTEINS;

EID: 84875272222     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.12.015     Document Type: Article

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