The major facilitator superfamily transporter mdtm contributes to the intrinsic resistance of Escherichia coli to quaternary ammonium compounds

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 4, 2013, Pages 831-839

  Holdsworth, Scarlett R ^a   Law, Christopher J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

AcrAB TolC; Antiporters; Integral membrane proteins; Secondary transporters

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; MAJOR FACILITATOR SUPERFAMILY TRANSPORTER MDTM; MEMBRANE PROTEIN; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL; BACTERIAL GROWTH; BINDING AFFINITY; CYTOTOXICITY; DRUG TRANSPORT; ESCHERICHIA COLI; GENE PRODUCT; GROWTH INHIBITION; IC 50; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TRANSPORT; PROTON TRANSPORT;

ANTIPORTERS; BIOLOGICAL TRANSPORT; DISINFECTANTS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; PROTEIN BINDING; QUATERNARY AMMONIUM COMPOUNDS;

EID: 84875261608     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks491     Document Type: Article

References (35)

1. Hegstad K, Langsrud S, Lunestad BT et al. Does the wide use of quaternary ammonium compounds enhance the selection and spread of antimicrobial resistance and thus threaten our health? Microb Drug Resist 2010; 16: 91-104.
2. Blenkinsopp SA, Costerton JW. Understanding bacterial biofilms. Trends Biotechnol 1991; 9: 138-43.
3. Tabata A, Nagamune H, Maeda T et al. Correlation between resistance of Pseudomonas aeruginosa to quaternary ammonium compounds and expression of outer membrane protein OprR. Antimicrob Agents Chemother 2003; 47: 2093-9.
4. Townsend DE, Greed L, Ashdown N et al. Plasmid-mediated resistance to quaternary ammonium compounds in methicillin-resistant Staphylococcus aureus. Med J Aust 1983; 2: 310.
5. Langsrud S, Sundheim G, Borgmann-Strahsen R. Intrinsic and acquired resistance to quaternary ammonium compounds in food-related Pseudomonas spp. J Appl Microbiol 2003; 95: 874-82.
6. Buffet-Bataillon S, Tattevin P, Bonnaure-Mallet M et al. Emergence of resistance to antibacterial agents: the role of quaternary ammonium compounds-a critical review. Int J Antimicrob Agents 2012; 39: 381-9.
7. Buffet-Bataillon S, Branger B, Cormier M et al. Effect of higher minimum inhibitory concentrations of quaternary ammonium compounds in clinical E. coli isolates on antibiotic susceptibilities and clinical outcomes. J Hosp Infect 2011; 79: 141-6.
8. McDonnell G, Russell AD. Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev 1999; 12: 147-79.
9. Ioannou CJ, Hanlon GW, Denyer SP. Action of disinfectant quaternary ammonium compounds against Staphylococcus aureus. Antimicrob Agents Chemother 2007; 51: 296-306.
10. Levy SB. Active efflux, a common mechanism for biocide and antibiotic resistance. J Appl Microbiol 2002; 92 (Suppl): 65S-71S.
11. McCay PH, Ocampo-Sosa AA, Fleming GT. Effect of subinhibitory concentrations of benzalkonium chloride on the competitiveness of Pseudomonas aeruginosa grown in continuous culture. Microbiology 2010; 156: 30-8.
12. Chung YJ, Saier MH Jr. Overexpression of the Escherichia coli sugE gene confers resistance to a narrow range of quaternary ammonium compounds. J Bacteriol 2002; 184: 2543-5.
13. Brown MH, Skurray RA. Staphylococcal multidrug efflux protein QacA. J Mol Microbiol Biotechnol 2001; 3: 163-70.
14. Nishino K, Yamaguchi A. Analysis of a complete library of putative drug transporter genes in Escherichia coli. J Bacteriol 2001; 183: 5803-12.
15. Edgar R, Bibi E. MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition. J Bacteriol 1997; 179: 2274-80.
16. Edgar R, Bibi E. A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA. EMBO J 1999; 18: 822-32.
17. Muth TR, Schuldiner S. A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE. EMBO J 2000; 19: 234-40.
18. Paulsen IT, Skurray RA, Tam R et al. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol Microbiol 1996; 19: 1167-75.
19. Schumacher MA, Brennan RG. Deciphering the molecular basis of multidrug recognition: crystal structures of the Staphylococcus aureus multidrug binding transcription regulator QacR. Res Microbiol 2003; 154: 69-77.
20. Sikora CW, Turner RJ. Investigation of ligand binding to the multidrug resistance protein EmrE by isothermal titration calorimetry. Biophys J 2005; 88: 475-82.
21. Holdsworth SR, Law CJ. Functional and biochemical characterisation of the Escherichia coli major facilitator superfamily multidrug transporter MdtM. Biochimie 2012; 94: 1334-46.
22. Saier MH Jr, Beatty JT, Goffeau A et al. The major facilitator superfamily. J Mol Microbiol Biotechnol 1999; 1: 257-79.
23. Soo VW, Hanson-Manful P, Patrick WM. Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli. Proc Natl Acad Sci USA 2011; 108: 1484-9.
24. Tal N, Schuldiner S. A coordinated network of transporters with overlapping specificities provides a robust survival strategy. Proc Natl Acad Sci USA 2009; 106: 9051-6.
25. Ferreira C, Pereira AM, Pereira MC et al. Physiological changes induced by the quaternary ammonium compound benzyldimethyldodecylammonium chloride on Pseudomonas fluorescens. J Antimicrob Chemother 2011; 66: 1036-43.
26. Morita Y, Kataoka A, Shiota S et al. NorM of Vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump. J Bacteriol 2000; 182: 6694-7.
27. Guzman LM, Belin D, Carson MJ et al. Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol 1995; 177: 4121-30.
28. Datsenko KA, Wanner BL. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci USA 2000; 97: 6640-5.
29. 50: an exactly defined measure of antibiotic sensitivity. J Antimicrob Chemother 1992; 29: 137-9.
30. Grkovic S, Hardie KM, Brown MH et al. Interactions of the QacR multidrug-binding protein with structurally diverse ligands: implications for the evolution of the binding pocket. Biochemistry 2003; 42: 15226-36.
31. Kummerer K. Resistance in the environment. J Antimicrob Chemother 2004; 54: 311-20.
32. Krulwich TA, Lewinson O, Padan E et al. Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study. Nat Rev Microbiol 2005; 3: 566-72.
33. Zgurskaya HI, Nikaido H. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc Natl Acad Sci USA 1999; 96: 7190-5.
34. Burland V, Plunkett G III, Sofia HJ et al. Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res 1995; 23: 2105-9.
35. Lewinson O, Bibi E. Evidence for simultaneous binding of dissimilar substrates by the Escherichia coli multidrug transporter MdfA. Biochemistry 2001; 40: 12612-8.