Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase

Molecular Medicine Reports

Volumn 7, Issue 4, 2013, Pages 1091-1095

  Yoshikawa, Nobuhiko ^a   Inomata, Taisuke ^b   Okada, Yoshikatsu ^a   Shimbo, Taiju ^a   Takahashi, Masatsugu ^c   Akita, Kazuhiko ^a   Uesugi, Yasuo ^a   Narumi, Yoshifumi ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b SHIMANE UNIVERSITY   (Japan)

^c Saito Yukoukai Hospital   (Japan)

Author keywords

Neutrophil elastase; Radiation induced lung injury; Sivelestat

Indexed keywords

LEUKOCYTE ELASTASE; SIVELESTAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; LUNG INJURY; MOUSE; NONHUMAN; RADIATION DOSE; RADIATION INJURY; SCORING SYSTEM;

ABNORMALITIES, RADIATION-INDUCED; ANIMALS; GLYCINE; HUMANS; INFLAMMATION; LEUKOCYTE ELASTASE; LUNG; LUNG INJURY; MICE; RADIATION-PROTECTIVE AGENTS; SULFONAMIDES;

EID: 84875257909     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1318     Document Type: Article

References (25)

1. Sekine I, Sumi M, Ito Y, et al: Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients. Radiother Oncol 80: 93-97, 2006.
2. Havemman K and Gramse M: Physiology and pathophysiology of neutral proteinases of human granulocytes. Adv Exp Med Biol 84: 1-20, 1984.
3. Kawabata K, Hagio T and Matsuoka S: The role of neutrophil elastase in acute lung injury. Eur J Pharmacol 451: 1-10, 2002.
4. Nakashima H, Akimoto A, Kitagawa T, et al: General pharmacological studies of sodium N-[2-[4-(2,2-dimethethyl-propionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046 Na). Pharmacometrics 54: 267-277, 1997 (In Japanese).
5. Shimbo T, Inomata T, Takahashi M, Tatsumi T, Uesugi Y, Narabayashi I and Sonobe H: Effects of sivelestat sodium hydrate on the reduction of radiation pneumonitis. Int J Mol Med 20: 817-822, 2007.
6. Kawabata K, Hagio T, Matsumoto S, Nakao S, Orita Y, Aze Y and Ohno H: Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamster. Am J Respir Crit Care Med 161: 2013-2018, 2000.
7. Movsas B, Raffin TA, Epstein AH and Link CJ Jr: Pulmonary radiation injury. Chest 111: 1061-1076, 1997.
8. Tsoutsou PG and Koukourakis MI: Radiation pneumonitis and fibrosis: mechanisms underlying its pathogenesis and implications for future research. Int J Radiat Oncol Biol Phys 66: 1281-1293, 2006.
9. Rubin P, Johnston CJ, Williams JP, McDonald S and Finkelstein JN: A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys 33: 99-109, 1995.
10. Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R and Finkelstein JN: Early and persistant alterations in the expression of interleukin-1α, interleukin-1β and tumor necrosis factor α mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat Res 145: 762-767, 1996.
11. Rübe CE, Uthe D, Wilfert F, et al: The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation. Int J Radiat Oncol Biol Phys 61: 1482-1492, 2005.
12. Mukaida N: Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol 284: L566-L577, 2003.
13. Araya J, Maruyama M, Sassa K, et al: Ionizing radiation enhances matrix metalloproteinase-2 production in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 280: L30-L38, 2001.
14. Yang K, Palm J, König J, et al: Matrix-metallo-proteinases and their tissue inhibitors in radiation-induced lung injury. Int J Radiat Biol 83: 665-676, 2007.
15. Rube CE, Uthe D, Schmid KW, et al: Dose-dependent induction of transforming growth factor β (TGF-β) in the lung tissue of fibrosis-prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys 47: 1033-1042, 2000.
16. Martin M, Lefaix J and Delanian S: TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys 47: 277-290, 2000.
17. Nishioka A, Ogawa Y, Mima T, et al: Histopathologic amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-beta) receptor mediated by adenoviral vector. Int J Radiat Oncol Biol Phys 58: 1235-1241, 2004.
18. Trott KR, Herrmann T and Kasper M: Target cells in radiation pneumopathy. Int J Radiat Oncol Biol Phys 58: 463-469, 2004.
19. Takemasa A, Ishii Y and Fukuda T: A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice. Eur Respir J 40: 1475-1482, 2012.
20. Hagio T, Matsumoto S, Nakao S, Abiru T, Ohno H and Kawabata K: Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters. Eur J Pharmacol 488: 173-180, 2004.
21. Taooka Y, Maeda A, Hiyama K, Ishioka S and Yamakido M: Effect of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 156: 260-265, 1997.
22. Hagio T, Nakao S, Matsuoka H, Matsumoto S, Kawabata K and Ohno H: Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster. Eur J Pharmacol 426: 131-138, 2001.
23. Yang T, Zhang J, Sun L, et al: Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats. Inflamm Res 61: 563-569, 2012.
24. Tamakuma S, Ogawa M, Aikawa N, et al: Relationship between neutrophil elastase and acute lung injury in humans. Pulm Pharmacol Ther 17: 271-279, 2004.
25. Hayakawa M, Katabami K, Wada T, Sugano M, Hoshino H, Sawamura A and Gando S: Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute distress syndrome and disseminated intravascular coagulation patients. Shock 33: 14-18, 2010.