Effects of sivelestat sodium hydrate on the reduction of radiation pneumonitis

International Journal of Molecular Medicine

Volumn 20, Issue 6, 2007, Pages 817-822

  Shimbo, Taiju ^a   Inomata, Taisuke ^a   Takahashi, Masatsugu ^a   Tatsumi, Toshiaki ^a   Uesugi, Yasuo ^a   Narabayashi, Isamu ^a   Sonobe, Hiroshi ^b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b CHUGOKU CENTRAL HOSPITAL   (Japan)

Author keywords

Neutrophil elastase; Radiation pneumonitis; Sivelestat sodium hydrate

Indexed keywords

DRUG DERIVATIVE; GLYCINE; LEUKOCYTE ELASTASE; SERINE PROTEINASE INHIBITOR; SIVELESTAT; SULFONAMIDE;

ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; FEMALE; IMMUNOLOGY; LUNG; METABOLISM; MOUSE; RADIATION EXPOSURE; RADIATION PNEUMONIA;

ANIMALS; FEMALE; GLYCINE; LEUKOCYTE ELASTASE; LUNG; MICE; MICE, INBRED C57BL; RADIATION PNEUMONITIS; SERINE PROTEINASE INHIBITORS; SULFONAMIDES;

EID: 42149128911     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.20.6.817     Document Type: Article

References (34)

1. Graeme WM, Pharm B, Samuel NB and Samuel NB: Radiation and the lung: A reevaluation of the mechanisms mediating pulmonary injury. Int J Radiat Oncol Biol Phys 31: 361-369, 1995.
2. Bayle JY, Nesme P, Bejui-Thivolet F, Loire R, Guerin JC and Cordier JF: Migratory organizing pneumonitis primed by radiation therapy. Eur Respir J 8: 322-326, 1995.
3. Hong JH, Chiang CS, Tsan CY, Lin PY, Wu CJ and McBride WH: Can short-term administration of dexamethasone abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular responses? Int J Radiat Oncol Biol Phys 51: 296-303, 2001.
4. Ward HE, Kemsley L, Davies L, Holecek M and Berend N: The effect of steroids on radiation-induced lung disease in the rat. Radiat Res 136: 22-28, 1993.
5. Sekine I, Sumi M, Ito Y, et al: Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients. Radiother Oncol 80: 93-97, 2006.
6. Kawabata K, Hagio T, Matsumoto S, Nakao S, Orita Y, Aze Y and Ohno H: Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamster. Am J Respir Crit Care Med 161: 2013-2018, 2000.
7. Hagio T, Nakao S, Matsuoka H, Matsumoto S, Kawabata K and Ohno H: Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster. Eur J Pharmacol 426: 131-138, 2001.
8. Taooka Y, Maeda A, Hiyama K, Ishioka S and Yamakido M: Effect of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 156: 260-265, 1997.
9. Folkesson HG, Matthay MA, Hébert CA and Broaddus VC: Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest 96: 107-116, 1995.
10. Hagio T, Matsumoto S, Nakao S, Abiru T, Ohno H and Kawabata K: Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters. Eur J Pharmacol 488: 173-180, 2004.
11. Wiener-Kronish JP, Gropper MA and Matthay MA: The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Br J Anaesth 65: 107-129, 1990.
12. Tamakura S, Ogawa M, Aikawa N, et al: Relationship between neutrophil elastase and acute lung injury in humans. Pulm Phamacol Ther 17: 271-279, 2004.
13. Ryugo M, Sawa Y, Tkano H, et al: Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double blind randomized study. Surg Today 36: 321-326, 2006.
14. Inoue Y, Tanaka H, Ogura H, et al: A neutrophil elastase inhibitor, Sivelestat improves leukocyte deformability in patients with acute lung injury. J Trauma 60: 936-943, 2006. (Pubitemid 43778617)
15. Peterson MW, Walter ME and Nygaard SD: Effect of neutrophil mediators on epithelial permeability. Am J Respir Cell Mol Biol 13: 719-727, 1995.
16. Suttorp N, Nolte A, Wilke A and Drenckhahn D: Human neutrophil elastase increases permeability of cultured pulmonary endothelial cell monolayers. Int J Microcirc Clin Exp 13: 187-203, 1993.
17. Owen CA, Campbell MA, Sannes PL, Boukedes SS and Campbell EJ: Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. J Cell Biol 131: 775-789, 1995.
18. Rocker GM, Pearson D, Wiseman MS and Shale DJ: Diagnostic criteria for adult respiratory distress syndrome: Time for reappraisal. Lancet 333: 120-123, 1989.
19. Havemman K and Gramse M: Physiology and pathophysiology of neutral proteinases of human granulocytes. Adv Exp Med Biol 84: 1-20, 1984.
20. Kawabata K, Hagio T and Matsuoka S: The role of neutrophil elastase in acute lung injury. Eur J Pharmacol 451: 1-10, 2002.
21. Claudia ER, Daniela U, Falk W, et al: The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation. Int J Radiat Oncol Biol Phys 61: 1482-1492, 2005.
22. Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R and Finkelstein JN: Early and persistant alterations in the expression of interleukin-1a, interleukin-1ß and tumor necrosis factor a mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation, Radiat Res 145: 762-767, 1996.
23. Rubin P, Johnston CJ, Williams JP, McDonald S and Finkelstein JN: A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys 33: 99-109, 1995.
24. Bedard M, McClure CD, Schiller NL, Francoeur C, Cantin A and Denis M: Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis. Am J Respir Cell Mol Biol 9: 455-462, 1993.
25. Nakamura H, Yoshimura K, McElvaney NG and Crystal RG: Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest 89: 1478-1484, 1992.
26. O'Brien-Ladner A, Nelson ME, Kimler BF and Wesselius LJ: Release of interleukin-1 by human alveolar macrophages after in vitro irradiation. Radiat Res 136: 37-41, 1993.
27. Beetz A, Messer G, Oppel T, Van Beuningen D, Peter RU and King P: Induction of interleukin 6 by ionizing radiation in a human epithelial cell line: Control by corticosteroids. Int J Radiat Biol 72: 33-43, 1997.
28. Kraus R, Steinberg F, Rehn B, Brush J and Streffer C: Radiation-induced changes in lung tissue and development of fibrosis determined by quantitative morphometric methods. J Cancer Res Clin Oncol 117: 27-32, 1991.
29. Franko AJ and Sharplin J: Development of fibrosis after lung irradiation in relation to inflammation and lung function in a mouse strain prone to fibrosis. Radiat Res 140: 347-355, 1994.
30. Woloschak GE, Chang-Liu C, Jones PS and Jones CA: Modulation of gene expression in Syrian hamster embryo cells following ionizing radiation. Cancer Res 50: 339-344, 1990.
31. Weiss SJ: Tissue destruction by neutrophils. N Engl J Med 320: 365-376, 1989.
32. Matheson NR, Wong PS and Travis J: Enzymatic inactivation of human alpha-1-proteinase inhibitor by neutrophil myeloperoxidase. Biochem Biophys Res Commun 88: 402-409, 1979.
33. Weitz JI, Huang AJ, Landman SL, Nicholson SC and Silverstein SC: Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases. J Exp Med 166: 1836-1850, 1987.
34. Kawabata K, Moore AR and Willoughby DA: Impaired activity of protease inhibitors towards neutrophil elastase bound to human articular cartilage. Ann Rheum Dis 55: 248-252, 1996.