Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 1, 1997, Pages 260-265

  Taooka, Yasuyuki ^a   Maeda, Akihiro ^a   Hiyama, Keiko ^a   Ishioka, Shinichi ^a   Yamakido, Michio ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ELASTASE INHIBITOR; LEUKOCYTE ELASTASE;

ANIMAL MODEL; ARTICLE; DRUG EFFECT; ENZYME INHIBITION; ENZYME LOCALIZATION; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030741005     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.1.9612077     Document Type: Article

References (35)

1. Golstein, R. H., and A. Fine. 1995. Potential therapeutic initiatives for fibrogenic lung disease. Chest 108:848-855.
2. Hunninghake, G. W., and A. R. Kalica. 1995. Approaches to the treatment of pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 151:915-918.
3. Crystal, R. G., P. B. Bitterman, S. I. Rennard, A. J. Hance, and B. A. Keogh. 1984. Interstitial lung diseases of unknown cause: disorders characterized by chronic inflammation of the lower respiratory tract (first of two parts). N. Engl. J. Med. 310:154-166.
4. Blum, R. H., S. K. Carter, and K. Agre. 1972. A clinical review of bleomycin: a new antineoplastic agent. Cancer 31:903-914.
5. Snider, G. L., J. A. Hayes, and A. L. Korthy. 1978. Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin: pathology and stereology. Am. Rev. Respir. Dis. 117:1099-1108.
6. Yamakido, M., S. Ishioka, and Y. Awaya. 1989. Role of alveolar macrophage in the development of pulmonary fibrosis. In M. Harasawa, Y. Fukuchi, and H. Morinari, editors. Interstitial Pneumonia of Unknown Etiology. Tokyo Press, Tokyo, Japan. 235-241.
7. Nagai, A., K. Aoshiba, Y. Ishihara, H. Inano, K. Sakamoto, E. Yamaguchi, J. Kagawa, and T. Takizawa. 1992. Administration of α1-proteinase inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters. Am. Rev. Respir. Dis: 145:651-656.
8. Döring, G. 1994. The role of neutrophil elastase in chronic inflammation. Am. J. Respir. Crit. Care Med. 150:S114-S117.
9. Yoshida, A., K. Kuramitu, H. Aoki, M. Nagata, and H. Kikuchi. 1987. Study on polymorphonucleocytal elastase-α1-protease inhibitor complex in bronchoalveolar lavage fluid (BALF). Jpn. J. Med. 27:60-63.
10. Mitsuhashi, H., S. Asano, T. Nonaka, I. Hamamura, K. Masuda, and M. Kiyoki. 1996. Administration of truncated secretory leukoprotease inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters. Am. J. Respir. Crit. Care Med. 153:369-374.
11. Kawabata, K., M. Suzuki, M. Sugitani, K. Imaki, M. Toda, and T. Miyamoto. 1991. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem. Biophys. Res. Commun. 177:814-820.
12. Sakamaki, F., A. Ishizaka, T. Urano, K. Sayama, H. Nakamura, T. Terashima, Y. Waki, S. Tasaka, N. Hasegawa, K. Sato, N. Nakagawa, T. Obata, and M. Kanazawa. 1996. Effect of a specific neutrophil elastase inhibitor. ONO-5046, on endotoxin-induced acute lung injury. Am. J. Respir. Crit. Care Med. 153:391-397.
13. Yasui, S., A. Nagai, K. Aoshiba, Y. Ozawa, Y. Kakuta, and K. Konno. 1995. A specific neutrophil elastase inhibitor (ONO-5046 ·Na) attenuates LPS-induced acute lung inflammation in the hamster. Eur. Respir. J. 8:1293-1299.
14. Maeda, A., K. Hiyama, H. Yamakido, S. Ishioka, and M. Yamakido. 1996. Increased expression of platelet-derived growth factor A and insulin-like growth factor-I in BAL cells during the development of bleomycin-induced pulmonary fibrosis in mice. Chest 109:780-786.
15. Lynch, J. P. III, T. J. Standiford, M. W. Rolfe, S. L. Kunkel, and R. M. Strieter. 1992. Neutrophilic alveolitis in idiopathic pulmonary fibrosis: the role of interleukin-8. Am. Rev. Respir. Dis. 145:1433-1439.
16. Kasama, T., R. M. Strieter, N. W. Lukacs, P. M. Lincoln, M. D. Burdick, and S. L. Kunkel. 1995. Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J. Clin. Invest. 95:2868-2876.
17. Ohtsuka, Y., M. Munakata, H. Ukita, T. Takahashi, A. Satoh, Y. Homma, and Y. Kawakami. 1995. Increased susceptibility to silicosis and TNF-α production in C57BL/6J mice. Am. J. Respir. Crit. Care Med. 152:2144-2149.
18. Ashcroft, T., J. M. Simpson, and V. Timbrell. 1988. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J. Clin. Pathol. 41:467-470.
19. Phan, S. H., S. R. Thrall, and C. Williams. 1981. Bleomycin-induced pulmonary fibrosis: effects of steroid on lung collagen metabolism. Am. Rev. Respir. Dis. 124:428-434.
20. Nakazawa, K., H. Tanaka, and M. Arima. 1982. Rapid, simultaneous and sensitive determination of free hydroxyproline and proline in human serum by high-performance liquid chromatography. J. Chromatogr. 233:313-316.
21. Montgomery, R. A., and M. J. Dallman. 1991. Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J. Immunol. 147:554-560.
22. Bonthron, D. T., P. Sultan, and T. Collins. 1991. Structure of the murine c-sis proto-oncogene (Sis, PDOFB) encoding the B chain of platelet-derived growth factor. Genomics 10:287-292.
23. Landreth, K. S., R. Narayanan, and K. Dorshkind. 1992. Insulin-like growth factor-I regulates pro-B cell differentiation. Blood 80:1207-1212.
24. Yamakido, H. 1996. Influence of smoking on the expression of various cytokines in murine bronchoalveolar lavage fluid cells. Allergology International 45:187-194.
25. Sibille, Y., and H. Y. Reynolds. 1990. Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am. Rev. Respir. Dis. 141:471-501.
26. Peterson, M. W., M. E. Walter, and S. D. Nygaard. 1995. Effect of neutrophil mediators on epithelial permeability. Am. J. Respir. Cell Mol. Biol. 13:719-727.
27. Castillo, I. J., K. Nakajima, M. Zimmerman, and J. C. Powers. 1979. Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Anal. Biochem. 99:53-64.
28. Shen, A. S., C. Haslett, D. C. Feldsien, P. M. Henson, and R. M. Cherniack. 1988. The intensity of chronic lung inflammation and fibrosis after bleomycin is directly related to the severity of acute injury. Am. Rev. Respir. Dis. 137:564-571.
29. Nakamura, H., K. Yoshimura, N. G. McElvaney, and R. G. Crystal. 1992. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J. Clin. Invest. 89:1478-1484.
30. Guo, L., Y. Yamaguchi, S. Ikei, H. Sugita, and M. Ogawa. 1995. Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis. Dig. Dis. Sci. 40:2177-2183.
31. Driscoll, K. E. 1994. Macrophage inflammatory protein: biology and role in pulmonary inflammation. Exp. Lung Res. 20:473-490.
32. Kelley, J. 1990. Cytokines of the lung. Am. Rev. Respir. Dis. 141:765-788.
33. Homma, S., I. Nagaoka, H. Abe, K. Takahashi, K. Seyama, T. Nukiwa, and S. Kira. 1995. Localization of platelet-derived growth factor and insulin-like growth factor I in the fibrotic lung. Am. J. Respir. Crit. Care Med. 152:2084-2089.
34. Nagaoka, I., B. C. Trapnell, and R. G. Crystal. 1990. Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis. J. Clin. Invest. 85:2023-2027.
35. Turner-Warwick, M., and P. L. Haslam. 1987. The value of serial bronchoalveolar lavages in assessing the clinical progress of patients with cryptogenic fibrosing alveolitis. Am. Rev. Respir. Dis. 135:26-34.