Novel inhibitors of bacterial virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1880-1897

  Yestrepsky, Bryan D ^a   Xu, Yuanxi ^b   Breen, Meghan E ^a   Li, Xiaoqin ^a   Rajeswaran, Walajapet G ^a   Ryu, Jenny G ^a   Sorenson, Roderick J ^a   Tsume, Yasuhiro ^a   Wilson, Michael W ^a   Zhang, Wenpeng ^a   Sun, Duxin ^a   Sun, Hongmin ^b   Larsen, Scott D ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b University of Missouri   (United States)

Author keywords

Antibiotic; Antibiotic resistance; Antivirulence; Biofilm; Group A Streptococcus; Metabolic oxidation; Streptokinase; Virulence inhibitor

Indexed keywords

3 ALLYL 2 (BUTYLTHIO) 3H SPIRO[BENZO[H]QUINAZOLINE 5,1 CYCLOHEXAN] 4(6H) ONE; 3 ALLYL 2 [(2 METHOXYETHYL)THIO] 5,5 DIMETHYL 4 OXO 3,4,5,6 TETRAHYDROBENZO[H]QUINAZOLINE 8 CARBOXYLIC ACID; 5,6 DIHYDROBENZO[H]QUINAZOLIN 4(3H) ONE DERIVATIVE; ANTIINFECTIVE AGENT; CCG 203592; CCG 205363; CCG 2979; METHYL 3 ALLYL 2 [(2 METHOXYETHYL)THIO] 5,5 DIMETHYL 4 OXO 3,4,5,6 TETRAHYDROBENZO[H]QUINAZOLINE 8 CARBOXYLATE; N [4 (((3 ALLYL 4 OXO 4,6 DIHYDRO 3H SPIRO(BENZO[H]QUINAZOLINE 5,1 CYCLOHEXAN)2 YL)THIO)METHYL)PHENYL]ACETAMIDE; STREPTOKINASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOFILM; CHEMICAL MODIFICATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS GROUP A;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOFILMS; CELL SURVIVAL; GENE EXPRESSION REGULATION, BACTERIAL; HELA CELLS; HUMANS; MICE; MICROSOMES, LIVER; QUINAZOLINES; SOLUBILITY; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS; STREPTOKINASE; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS SP. 'GROUP A';

EID: 84875223783     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.046     Document Type: Article

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