First computational chemistry multi-target model for anti-Alzheimer, anti-parasitic, anti-fungi, and anti-bacterial activity of GSK-3 inhibitors in vitro, in vivo, and in different cellular lines

Molecular Diversity

Volumn 15, Issue 2, 2011, Pages 561-567

  García, Isela ^a   Fall, Yagamare ^a   Gómez, Generosa ^a   González Díaz, Humberto ^b  

^a UNIVERSITY OF VIGO   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Alzheimer's disease; Glycogen synthase kinase 3 (GSK 3) inhibitors; Linear discriminant analysis; Malaria; Markov model; Plasmodium falciparum; QSAR; Trypanosoma brucei; Trypanosomiasis

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIPARASITIC AGENT; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ALZHEIMER DISEASE; ANTIBACTERIAL ACTIVITY; ARTICLE; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA DONOVANI; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; ALGORITHM; ANIMAL; CELL LINE; CELL STRAIN HT29; CELL STRAIN U937; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; HUMAN; METABOLISM; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

ALGORITHMS; ALZHEIMER DISEASE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTIPARASITIC AGENTS; CELL LINE; COMPUTER SIMULATION; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HT29 CELLS; HUMANS; MODELS, STATISTICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; U937 CELLS;

EID: 80051566363     PISSN: 13811991     EISSN: 1573501X     Source Type: Journal    
DOI: 10.1007/s11030-010-9280-3     Document Type: Article

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