Altered expression of genes involved in progesterone biosynthesis, metabolism and action in endometrial cancer

Chemico-Biological Interactions

Volumn 202, Issue 1-3, 2013, Pages 210-217

  Sinreih, Maša ^a   Hevir, Neli ^a   Rižner, Tea Lanišnik ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

3 Keto 20 keto reductase; 5 Reductase; Pre receptor metabolism; Side chain cleavage enzyme; Steroidogenic acute regulatory protein

Indexed keywords

MESSENGER RNA; PROGESTERONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ADULT; AKR1C1 GENE; AKR1C2 GENE; AKR1C3 GENE; BIOSYNTHESIS; CANCER GRADING; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CYP11A1 GENE; DOWN REGULATION; ENDOMETRIUM CANCER; FEMALE; GENE EXPRESSION; GENE FUNCTION; HSD3B GENE; HSD3B2 GENE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; ONCOGENE; POSTMENOPAUSE; PR A GENE; PR B GENE; PREMENOPAUSE; PROGESTERONE BIOSYNTHESIS; PROGESTERONE METABOLISM; PROTEIN EXPRESSION; UPREGULATION;

17-HYDROXYSTEROID DEHYDROGENASES; 20-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYSTEROID DEHYDROGENASES; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; ADULT; AGED; AGED, 80 AND OVER; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DOWN-REGULATION; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; ESTRADIOL DEHYDROGENASES; FEMALE; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; MEMBRANE PROTEINS; MIDDLE AGED; MULTIENZYME COMPLEXES; PHOSPHOPROTEINS; PROGESTERONE; PROGESTERONE REDUCTASE; RECEPTORS, PROGESTERONE; RNA, MESSENGER; STEROID ISOMERASES;

EID: 84875217796     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.11.012     Document Type: Conference Paper

References (38)

1. < http://globocan.iarc.fr/factsheet.asp#BOTH >.
2. A.E. Schindler Progestogen deficiency and endometrial cancer risk Maturitas 62 2009 334 337
3. T. Kaku, H. Yoshikawa, H. Tsuda, A. Sakamoto, M. Fukunaga, Y. Kuwabara, M. Hataeg, S. Kodama, K. Kuzuya, S. Sato, T. Nishimura, M. Hiura, H. Nakano, T. Iwasaka, K. Miyazaki, and T. Kamura Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: central pathologic review and treatment outcome Cancer Lett. 167 2001 39 48
4. K. Niwa, K. Tagami, Z. Lian, K. Onogi, H. Mori, and T. Tamaya Outcome of fertility-preserving treatment in young women with endometrial carcinomas B.J.O.G. 112 2005 317 320
5. A.J. Ryan, B. Susil, T.W. Jobling, and M.K. Oehler Endometrial cancer Cell Tissue Res. 322 2005 53 61
6. F. Amant, P. Moerman, P. Neven, D. Timmerman, E. Van Limbergen, and I. Vergote Endometrial cancer Lancet 366 2005 491 505
7. Y. Sonoda, and R.R. Barakat Screening and the prevention of gynecologic cancer: endometrial cancer Best Pract. Res. Clin. Obstet. Gynaecol. 20 2006 363 377
8. T.J. Key, and M.C. Pike The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk Br. J. Cancer 57 1988 205 212
9. T. Sugawara, E. Nomura, and S. Fujimoto Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells J. Endocrinol. 180 2004 135 144
10. S.A. Missmer, A.H. Eliassen, R.L. Barbieri, and S.E. Hankinson Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women J. Natl Cancer Inst. 96 2004 1856 1865
11. P.R. Manna, M.T. Dyson, and D.M. Stocco Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives Mol. Hum. Reprod. 15 2009 321 333
12. W.L. Miller Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter Biochim. Biophys. Acta 1771 2007 663 676
13. H.S. Rhee, S.H. Oh, B.J. Ko, D.M. Han, B.H. Jeon, H. Park, H.B. Moon, and W.S. Kim Expression of 3beta-hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium Exp. Mol. Med. 35 2003 160 166
14. T.M. Penning, Y. Jin, S. Steckelbroeck, T. Lanisnik Rizner, and M. Lewis Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins Mol. Cell. Endocrinol. 215 2004 63 72
15. L. Wu, M. Einstein, W.M. Geissler, H.K. Chan, K.O. Elliston, and S. Andersson Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity J. Biol. Chem. 268 1993 12964 12969
16. T.M. Penning, M.E. Burczynski, J.M. Jez, C.F. Hung, H.K. Lin, H. Ma, M. Moore, N. Palackal, and K. Ratnam Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones Biochem. J. 351 2000 67 77
17. S. Steckelbroeck, Y. Jin, S. Gopishetty, B. Oyesanmi, and T.M. Penning Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action J. Biol. Chem. 279 2004 10784 10795
18. T. Miyamoto, J. Watanabe, H. Hata, T. Jobo, M. Kawaguchi, M. Hattori, M. Saito, and H. Kuramoto Significance of progesterone receptor-A and -B expressions in endometrial adenocarcinoma J. Steroid Biochem. Mol. Biol. 92 2004 111 118
19. G.R. Attia, K. Zeitoun, D. Edwards, A. Johns, B.R. Carr, and S.E. Bulun Progesterone receptor isoform A but not B is expressed in endometriosis J. Clin. Endocrinol. Metab. 85 2000 2897 2902
20. S. Yang, K.W. Thiel, and K.K. Leslie Progesterone: the ultimate endometrial tumor suppressor Trends Endocrinol. Metab. 22 2011 145 152
21. N. Shabani, C. Kuhn, S. Kunze, S. Schulze, D. Mayr, D. Dian, A. Gingelmaier, C. Schindlbeck, F. Willgeroth, H. Sommer, U. Jeschke, K. Friese, and I. Mylonas Prognostic significance of oestrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas Eur. J. Cancer 43 2007 2434 2444
22. F. Collins, S. MacPherson, P. Brown, V. Bombail, A.R. Williams, R.A. Anderson, H.N. Jabbour, and P.T. Saunders Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha BMC Cancer 9 2009 330
23. N. Hevir, J. Šinkovec, and T. Lanišnik Rižner Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT Mol. Cell. Endocrinol. 331 2011 158 167
24. T. Lanišnik Rižner, T. Šmuc, R. Rupreht, J. Šinkovec, and T.M. Penning AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer Mol. Cell. Endocrinol. 248 2006 126 135
25. S.A. Bustin, V. Benes, J.A. Garson, J. Hellemans, J. Huggett, M. Kubista, R. Mueller, T. Nolan, M.W. Pfaffl, G.L. Shipley, J. Vandesompele, and C.T. Wittwer The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments Clin. Chem. 55 2009 611 622
26. J.A. Collins, and D.M. Jewkes Progesterone metabolism by proliferative and secretory human endometrium Am. J. Obstet. Gynecol. 118 1974 179 185
27. T. Smuc, and T.L. Rizner Aberrant pre-receptor regulation of estrogen and progesterone action in endometrial cancer Mol. Cell Endocrinol. 301 2009 74 82
28. V. Zakharov, H.K. Lin, J. Azzarello, S. McMeekin, K.N. Moore, T.M. Penning, and K.M. Fung Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma Int. J. Clin. Exp. Pathol. 3 2010 608 617
29. H.K. Lin, S. Steckelbroeck, K.M. Fung, A.N. Jones, and T.M. Penning Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate Steroids 69 2004 795 801
30. M.S. Mahendroo, and D.W. Russell Male and female isoenzymes of steroid 5alpha-reductase Rev. Reprod. 4 1999 179 183
31. D.W. Russell, and J.D. Wilson Steroid 5 alpha-reductase: two genes/two enzymes Annu. Rev. Biochem. 63 1994 25 61
32. M.A. Levy, M. Brandt, K.M. Sheedy, D.A. Holt, J.I. Heaslip, J.J. Trill, P.J. Ryan, R.A. Morris, L.M. Garrison, and D.J. Bergsma Cloning, expression and functioal characterization of type 1 and type 2 steroid 5 alpha-reductases from Cynomolgus monkey: comparisons with human and rat isoenzymes J. Steroid Biochem. Mol. Biol. 52 1995 307 319
33. W. Kazmierczak, P. Skalba, A. Dabkowska-Huc, and A. Samojedny Expression of aromatase and 5-alpha-reductase genes in endometrial adenocarcinoma Pathol. Res. Pract. 202 2006 789 791
34. T. Šmuc, R. Rupreht, J. Šinkovec, J. Adamski, and T. Lanišnik Rižner Expression analysis of estrogen-metabolizing enzymes in human endometrial cancer Mol. Cell. Endocrinol. 248 2006 114 117
35. J. Lepine, E. Audet-Walsh, J. Gregoire, B. Tetu, M. Plante, V. Menard, P. Ayotte, J. Brisson, P. Caron, L. Villeneuve, A. Belanger, and C. Guillemette Circulating estrogens in endometrial cancer cases and their relationship with tissular expression of key estrogen biosynthesis and metabolic pathways J. Clin. Endocrinol. Metab. 95 2010 2689 2698
36. H. Utsunomiya, T. Suzuki, C. Kaneko, J. Takeyama, J. Nakamura, K. Kimura, M. Yoshihama, N. Harada, K. Ito, R. Konno, S. Sato, K. Okamura, and H. Sasano The analyses of 17beta-hydroxysteroid dehydrogenase isozymes in human endometrial hyperplasia and carcinoma J. Clin. Endocrinol. Metab. 86 2001 3436 3443
37. K.M. Cornel, R.F. Kruitwagen, B. Delvoux, L. Visconti, K.K. Van de Vijver, J.M. Day, T. Van Gorp, R.J. Hermans, G.A. Dunselman, and A. Romano Overexpression of 17beta-hydroxysteroid dehydrogenase type 1 increases the exposure of endometrial cancer to 17beta-estradiol J. Clin. Endocrinol. Metab. 97 2012 E591 E601
38. R.L. Arnett-Mansfield, A. deFazio, G.V. Wain, R.C. Jaworski, K. Byth, P.A. Mote, and C.L. Clarke Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium Cancer Res. 61 2001 4576 4582