Male and female isoenzymes of steroid 5α-reductase

Reviews of Reproduction

Volumn 4, Issue 3, 1999, Pages 179-183

  Mahendroo, Mala S ^a   Russell, David W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOENZYME; STEROID 5ALPHA REDUCTASE; STEROID HORMONE;

CATALYSIS; DEVELOPMENT; ENZYME MECHANISM; FEMALE FERTILITY; GENE CONTROL; GENE MUTATION; HUMAN; HYPOTHESIS; MAMMAL; NONHUMAN; PRIORITY JOURNAL; REPRODUCTION; SEX DIFFERENCE; SHORT SURVEY; STEROID METABOLISM; STEROIDOGENESIS; UTERINE CERVIX;

ANIMALS; CERVICAL RIPENING; FEMALE; FERTILITY; ISOENZYMES; MALE; MICE; MUTATION; OBSTETRIC LABOR COMPLICATIONS; PREGNANCY; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0032826077     PISSN: 13596004     EISSN: None     Source Type: Journal    
DOI: 10.1530/ror.0.0040179     Document Type: Short Survey

References (9)

1. Berman DM, Tian H and Russell DW (1995) Expression and regulation of steroid 5α-reductase in the urogenital tract of the fetal rat Molecular Endocrinology 9 1561-1570
2. Doolittle DP, Davisson MT, Guidi JN and Green MC (1996) Catalog of mutant genes and polymorphic loci. In Genetic Variants and Strains of the Laboratory Mouse pp 17-854 Eds ME Lyon, S Rastan and SDM Brown. Oxford University Press, Oxford
3. Fisher LK, Kogun MD, Moore RJ, Goebelsmann U, Weitman JJ, Isaacs HJ, Griffin JE and Wilson JD (1978) Clinical, endocrinological, and enzymatic characterization of two patients with 5α-reductase deficiency: evidence that a single enzyme is responsible for the 5α-reduction of cortisol and testosterone Journal of Clinical Endocrinology and Metabolism 47 653-664
4. Levine AC, Wang J-P, Ren M, Eliashvili E, Russell DW and Kirschenbaum A (1996) Immunohistochemical localization of steroid 5α-reductase 2 in human male fetal reproductive tract and adult prostate Journal of Clinical Endocrinology and Metabolism 81 384-389
5. Mahendroo MS, Cala KM and Russell DW (1996) 5α-Reduced androgens play a key role in murine parturition Molecular Endocrinology 10 380-392
6. Mahendroo MS, Cala KM, Landrum CP and Russell DW (1997) Fetal death in mice lacking 5α-reductase type 1 caused by estrogen excess Molecular Endocrinology 11 917-927
7. Mahendroo MS, Porter A, Russell DW and Word RA (1999) The parturition defect in steroid 5α-reductase type 1 knockout mice is due to impaired cervical ripening Molecular Endocrinology 13 981-992
8. Milewich L, Mendonca BB, Arnhold I, Wallace AM, Donaldson MDC, Wilson JD and Russell DW (1995) Women with steroid 5α-reductase 2 deficiency have normal concentrations of plasma 5α-dihydroprogesterone during the luteal phase Journal of Clinical Endocrinology and Metabolism 80 3136-3139
9. Normington K and Russell DW (1992) Tissue distribution and kinetic - characteristics of rat steroid 5α-reductase isozymes. Evidence for distinct physiological functions Journal of Biological Chemistry 267 19 548-19 554