Progesterone receptor isoform A but not B is expressed in endometriosis

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 8, 2000, Pages 2897-2902

  Attia, George R ^a   Zeitoun, Khaled ^a   Edwards, Dean ^b   Johns, Alan ^a   Carr, Bruce R ^a   Bulun, Serdar E ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 2; ESTRADIOL; ESTRONE; GESTAGEN; PROGESTERONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; LAPAROSCOPY; LUTEAL PHASE; MENSTRUAL CYCLE; OVULATION; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; DIMERIZATION; ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; HUMANS; MENSTRUAL CYCLE; RECEPTORS, PROGESTERONE; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0034457983     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.8.2897     Document Type: Article

References (35)

1. Epidemiology of endometriosis-associated infertility
2. Epidemiology of endometriosis
3. Familial endometriosis
4. Deficient 17β-hydroxysteroid dehydrogenase type 2 expression in endometriosis: Failure to metabolize 17β-estradiol
5. Distribution of progesterone receptor, estradiol dehydrogenase, and 20α-dihydroprogesterone dehydrogenase activities in human endometrial glands and stroma: Progestin induction of steroid dehydrogenase activities in vitro is restricted to the glandular epithelium
6. Induction of human endometrial estradiol dehydrogenase by progestins
7. Gene regulation by steroid hormones
8. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B
9. In situ photo linked nuclear progesterone receptors of human breast cancer cells: Subunit molecular weights after transformation and translocation
10. Progestin inhibition of progesterone receptor gene expression in human breast cancer cells
11. The subunit structure of human breast cancer progesterone receptors: Characterization by chromatography and photaffinity labeling
12. The A and B forms of a chicken progesterone receptor arise by alternate initiation of translation of the unique mRNA
13. Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms
14. The N-terminal region of the chicken progesterone receptor specifies target gene activation
15. Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors
16. Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function
17. RU486 exerts anti-estrogenic activities through a novel progesterone receptor A form-mediated mechanism
18. The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells
19. Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor
20. Control of transcription of the chicken progesterone receptor gene. In vitro and in vivo studies
21. Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium
22. Differential expression of uterine progesterone receptor forms A and B during the menstrual cycle
23. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
24. Expression of progesterone receptor form A and B mRNAs in uterine leiomyoma
25. Effects of hormone and cellular modifiers of protein phosphorylation on transcriptional activity, DNA binding and phosphorylation of human progesterone receptor
26. Colocalization of progesterone receptors A and B by dual immunofluorescent histochemistry in human endometrium during the menstrual cycle
27. Ovarian steroid receptor expression in endometriosis and in two potential parent epithelia: Endometrium and peritoneal mesothelium
28. Oestrogen and progesterone receptors in endometriotic tissue and endometrium: Comparison of different cycle phases and ages
29. Estrogen and progesterone receptors in endometriotic tissue and endometrium: Comparison according to localization and recurrence
30. Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis
31. Quantitative enzyme immunoassay and semiquantitative immunohistochemistry of oestrogen and progesterone receptors in endometriotic tissue and endometrium
32. Dominant expression of progesterone receptor form B mRNA in ovarian endometriosis
33. Use of immununocytochemistry of progesterone and estrogen receptors for endometrial dating
34. Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle
35. Immunohistochemical analysis of the peritoneum adjacent to endometriotic lesions using antibodies for Ber-EP4 antigen, estrogen receptors, and progesterone receptors: Implication of peritoneal metaplasia in the pathogenesis of endometriosis