Kurarinone regulates immune responses through regulation of the JAK/STAT and TCR-mediated signaling pathways

Biochemical Pharmacology

Volumn 85, Issue 8, 2013, Pages 1134-1144

  Kim, Byung Hak ^a   Na, Kwang Min ^a   Oh, Ikhoon ^b   Song, Inn Hye ^b   Lee, Yun Sang ^a   Shin, Jongheon ^b   Kim, Tae Yoon ^a  

^a The Catholic University of Korea   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Autoimmune disease; CD4+ T cell; Immune response; JAK STAT; Kurarinone; T cell receptor

Indexed keywords

8 LAVANDULYLKAEMPFEROL; FLAVONOID; INTERLEUKIN 23; JANUS KINASE; KURARIDIN; KURARINOL; KURARINONE; KUSHENOL I; KUSHENOL M; KUSHENOL N; MAACKIAIN; PICRYL CHLORIDE; SOPHORACARPAN; STAT PROTEIN; T LYMPHOCYTE RECEPTOR; TRIFOLIRHIZIN; UNCLASSIFIED DRUG; VARIABILIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL LINEAGE; CELL VIABILITY; CONTACT DERMATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; SIGNAL TRANSDUCTION; SOPHORA FLAVESCENS; T LYMPHOCYTE;

ANIMALS; ANTIOXIDANTS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOKINES; FLAVONOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; JANUS KINASES; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 84875216671     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.01.005     Document Type: Article

References (69)

1. A.K. Abbas, K.M. Murphy, and A. Sher Functional diversity of helper T lymphocytes Nature 383 1996 787 793
2. C. Dong Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells Nat Rev Immunol 6 2006 329 333
3. Y. Iwakura, and H. Ishigame The IL-23/IL-17 axis in inflammation J Clin Invest 116 2006 1218 1222
4. J. Zhu, H. Yamane, and W.E. Paul Differentiation of effector CD4 T cell populations Annu Rev Immunol 28 2010 445 489
5. H. Conroy, N.A. Marshall, and K.H. Mills TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours Oncogene 27 2008 168 180
6. K.M. Murphy, and S.L. Reiner The lineage decisions of helper T cells Nat Rev Immunol 2 2002 933 944
7. J. Zhu, and W.E. Paul Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors Immunol Rev 238 2010 247 262
8. C.E. Egwuagu STAT3 in CD4+ T helper cell differentiation and inflammatory diseases Cytokine 47 2009 149 156
9. K. Shuai, and B. Liu Regulation of JAK-STAT signalling in the immune system Nat Rev Immunol 3 2003 900 911
10. J.E. Smith-Garvin, G.A. Koretzky, and M.S. Jordan T cell activation Annu Rev Immunol 27 2009 591 619
11. R.J. Salmond, A. Filby, I. Qureshi, S. Caserta, and R. Zamoyska T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance Immunol Rev 228 2009 9 22
12. A. Khoshnan, D. Bae, C.A. Tindell, and A.E. Nel The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28 J Immunol 165 2000 6933 6940
13. R. Weil, K. Schwamborn, A. Alcover, C. Bessia, V. Di Bartolo, and A. Israël Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor Immunity 18 2003 13 26
14. M.S. Hayden, A.P. West, and S. Ghosh NF-kappaB and the immune response Oncogene 25 2006 6758 6780
15. T.H. Watts TNF/TNFR family members in costimulation of T cell responses Annu Rev Immunol 23 2005 23 68
16. T. Nakayama, and M. Yamashita The TCR-mediated signaling pathways that control the direction of helper T cell differentiation Semin Immunol 22 2010 303 309
17. D.W. Kim, Y.S. Chi, K.H. Son, H.W. Chang, J.S. Kim, and S.S. Kang Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response Arch Pharm Res 25 2002 329 335
18. M.H. Hong, J.Y. Lee, H. Jung, D.H. Jin, H.Y. Go, and J.H. Kim Sophora flavescens Aiton inhibits the production of pro-inflammatory cytokines through inhibition of the NF kappaB/IkappaB signal pathway in human mast cell line (HMC-1) Toxicol In Vitro 23 2009 251 258
19. J.H. Jin, J.S. Kim, S.S. Kang, K.H. Son, H.W. Chang, and H.P. Kim Anti-inflammatory,anti-arthritic activity of total flavonoids of the roots of Sophora flavescens J Ethnopharmacol 127 2010 589 595
20. J.D. Cha, S.E. Moon, J.Y. Kim, E.K. Jung, and Y.S. Lee Antibacterial activity of sophoraflavanone G isolated from the roots of Sophora flavescens against methicillin-resistant Staphylococcus aureus Phytother Res 23 2009 1326 1331
21. I. Oh, W.Y. Yang, S.C. Chung, T.Y. Kim, K.B. Oh, and J. Shin In vitro sortase a inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens Arch Pharm Res 34 2011 217 222
22. M. Sun, J. Han, J. Duan, Y. Cui, T. Wang, and W. Zhang Novel antitumor activities of Kushen flavonoids in vitro and in vivo Phytother Res 21 2007 269 277
23. Z. Lin, C.F. Huang, X.S. Liu, and J. Jiang In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait Basic Clin Pharmacol Toxicol 108 2011 304 309
24. S.J. Park, K.W. Nam, H.J. Lee, E.Y. Cho, U. Koo, and W. Mar Neuroprotective effects of an alkaloid-free ethyl acetate extract from the root of Sophora flavescens Ait against focal cerebral ischemia in rats Phytomedicine 16 2009 1042 1051
25. X.L. Piao, X.S. Piao, S.W. Kim, J.H. Park, H.Y. Kim, and S.Q. Cai Identification and characterization of antioxidants from Sophora flavescens Biol Pharm Bull 29 2006 1911 1915
26. G.S. Jeong, B. Li, D.S. Lee, E. Byun, R.B. An, and H.O. Pae Lavandulyl flavanones from Sophora flavescens protect mouse hippocampal cells against glutamate-induced neurotoxicity via the induction of heme oxygenase-1 Biol Pharm Bull 31 2008 1964 1967
27. A. De Naeyer, W. Vanden Berghe, V. Pocock, S. Milligan, G. Haegeman, and D. De Keukeleire Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens J Nat Prod 67 2004 1829 1832
28. T.S. Jeong, Y.B. Ryu, H.Y. Kim, M.J. Curtis-Long, S.J. An, and J.H. Lee Low density lipoprotein (LDL)-antioxidant flavonoids from roots of Sophora flavescens Biol Pharm Bull 31 2008 2097 2102
29. S.J. Kim, K.H. Son, H.W. Chang, S.S. Kang, and H.P. Kim Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens Biol Pharm Bull 26 2003 1348 1350
30. J.K. Son, J.S. Park, J.A. Kim, Y. Kim, S.R. Chung, and S.H. Lee Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity Planta Med 69 2003 559 561
31. J.H. Kim, Y.B. Ryu, N.S. Kang, B.W. Lee, J.S. Heo, and I.Y. Jeong Glycosidase inhibitory flavonoids from Sophora flavescens Biol Pharm Bull 29 2006 302 305
32. Y. Kim, B.H. Kim, H. Lee, B. Jeon, Y.S. Lee, and M.J. Kwon Regulation of skin inflammation and angiogenesis by EC-SOD via HIF-1α and NF-κB pathways Free Radic Biol Med 51 2011 1985 1995
33. Y.S. Lee, I.S. Cheon, B.H. Kim, M.J. Kwon, H.W. Lee, and Kim TY Loss of extracellular superoxide dismutase induces severe IL-23-mediated skin inflammation in mice J Invest Dermatol 2012 Epub ahead of print
34. K. Na, K.E. Kim, S.T. Park, and T.Y. Kim EC-SOD suppresses contact hypersensitivity in mouse skin by impairing langerhans cell migration J Invest Dermatol 127 2007 1930 1937
35. E.J. Lee, M.S. Jeon, B.D. Kim, J.H. Kim, Y.G. Kwon, and H. Lee Capsiate inhibits ultraviolet B-induced skin inflammation by inhibiting Src family kinases and epidermal growth factor receptor signaling Free Radic Biol Med 48 2010 1133 1143
36. J. Zhu, and W.E. Paul CD4 T cells: fates, functions, and faults Blood 112 2008 1557 1569
37. C. Asseman, S. Mauze, M.W. Leach, R.L. Coffman, and F. Powrie An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation J Exp Med 190 1999 995 1004
38. S. Rutz, and W. Ouyang Regulation of interleukin-10 and interleukin-22 expression in T helper cells Curr Opin Immunol 23 2011 605 612
39. J.J. O'Shea, R. Lahesmaa, G. Vahedi, A. Laurence, and Y. Kanno Genomic views of STAT function in CD4+ T helper cell differentiation Nat Rev Immunol 11 2011 239 250
40. C. Luo, and P. Laaja Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs Drug Discov Today 9 2004 268 275
41. H. Yu, D. Pardoll, and R. Jove STATs in cancer inflammation and immunity: a leading role for STAT3 Nat Rev Cancer 9 2009 798 809
42. T. Tamiya, I. Kashiwagi, R. Takahashi, H. Yasukawa, and A. Yoshimura Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3 Arterioscler Thromb Vasc Biol 31 2011 980 985
43. E. Fitch, E. Harper, I. Skorcheva, S.E. Kurtz, and A. Blauvelt Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines Curr Rheumatol Rep 9 2007 461 467
44. Y. Liu, C. Helms, W. Liao, L.C. Zaba, S. Duan, and J. Gardner A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci PLoS Genet 4 2008 e1000041
45. L. Melis, B. Vandooren, E. Kruithof, P. Jacques, M. De Vos, and H. Mielants Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis Ann Rheum Dis 69 2010 618 623
46. K.E. Nograles, B. Davidovici, and J.G. Krueger New insights in the immunologic basis of psoriasis Semin Cutan Med Surg 29 2010 3 9
47. M.S. Maddur, P. Miossec, S.V. Kaveri, and J. Bayry Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies Am J Pathol 181 2012 8 18
48. H. Kitagaki, N. Ono, K. Hayakawa, T. Kitazawa, K. Watanabe, and T. Shiohara Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile J Immunol 159 1997 2484 2491
49. T. Shiohara, J. Hayakawa, and Y. Mizukawa Animal models for atopic dermatitis: are they relevant to human disease J Dermatol Sci 36 2004 1 9
50. K.J. O'Byrne, and A.G. Dalgleish Chronic immune activation and inflammation as the cause of malignancy Br J Cancer 85 2001 473 483
51. M. Johansson, D.G. Denardo, and L.M. Coussens Polarized immune responses differentially regulate cancer development Immunol Rev 222 2008 145 154
52. A. Shanker, and F.M. Marincola Cooperativity of adaptive and innate immunity: implications for cancer therapy Cancer Immunol Immunother 60 2011 1061 1074
53. J.A. Grasis, and C.D. Tsoukas Itk: the rheostat of the T cell response J Signal Transduct 2011 2011 297868
54. J.J. O'Shea, H. Park, M. Pesu, D. Borie, and P. Changelian New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway Curr Opin Rheumatol 17 2005 305 311
55. K. West C.P-690550 a JAK3 inhibitor as an immunosuppressant for the treatment of rheumatoid arthritis, transplant rejection, psoriasis and other immune-mediated disorders Curr Opin Investig Drugs 10 2009 491 504
56. M.E. Flanagan, T.A. Blumenkopf, W.H. Brissette, M.F. Brown, J.M. Casavant, and C. Shang-Poa Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection J Med Chem 53 2010 8468 8484
57. B.D. Page, D.P. Ball, and P.T. Gunning Signal transducer and activator of transcription 3 inhibitors: a patent review Expert Opin Ther Pat 21 2011 65 83
58. S. Haftchenary, M. Avadisian, and P.T. Gunning Inhibiting aberrant Stat3 function with molecular therapeutics: a progress report Anticancer Drugs 22 2011 115 127
59. K. Miyoshi, M. Takaishi, K. Nakajima, M. Ikeda, T. Kanda, and M. Tarutani Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor J Invest Dermatol 131 2011 108 117
60. A. Pardanani, A.M. Vannucchi, F. Passamonti, F. Cervantes, T. Barbui, and A. Tefferi JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations Leukemia 25 2011 218 225
61. Y. Tokura, T. Mori, and R. Hino Psoriasis and other Th17-mediated skin diseases J UOEH 32 2010 317 328
62. K. Nakajima, T. Kanda, M. Takaishi, T. Shiga, K. Miyoshi, and H. Nakajima Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model J Immunol 186 2011 4481 4489
63. M.M. Davis A new trigger for T cells Cell 110 2002 285 287
64. M.M. Davis Src-family kinases: rheostats of immune cell signaling Mol Immunol 41 2004 631 643
65. D. Ghosh, and G.C. Tsokos Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases Autoimmunity 43 2010 48 55
66. K. Okkenhaug, and B. Vanhaesebroeck PI3K in lymphocyte development, differentiation and activation Nat Rev Immunol 3 2003 317 330
67. L. So, and D.A. Fruman PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances Biochem J 442 2012 465 481
68. M.Q. Man, Y. Hatano, S.H. Lee, M. Man, S. Chang, and K.R. Feingold Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges J Invest Dermatol 128 2008 79 86
69. E. Toussirot The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases Inflamm Allergy Drug Targets 11 2012 159 168